High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway

Ferroptosis: mechanisms, biology and role in disease

(2021) Xuejun Jiang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pharmacological inhibition of MELK restricts ferroptosis and the inflammatory response in colitis and colitis-propelled carcinogenesis

(2021) Bufu Tang et al.   FREE RADICAL BIOLOGY AND MEDICINE

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

(2021) Zhaohui Pei et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

High-fat diet–induced colonocyte dysfunction escalates microbiota-derived trimethylamine N-oxide

(2021) Woongjae Yoo et al.   SCIENCE

RSL3 enhances the antitumor effect of cisplatin on prostate cancer cells via causing glycolysis dysfunction

(2021) Mengxin Li et al.   BIOCHEMICAL PHARMACOLOGY

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells

(2020) Nick Powell et al.   GUT

Aging Increases the Severity of Colitis and the Related Changes to the Gut Barrier and Gut Microbiota in Humans and Mice

(2020) Ailing Liu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ferroptosis involves in intestinal epithelial cell death in ulcerative colitis

(2020) Minyi Xu et al.   Cell Death & Disease

Redox homeostasis maintained by GPX4 facilitates STING activation

(2020) Mutian Jia et al.   NATURE IMMUNOLOGY

Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4

(2020) Shujun Wang et al.   LIFE SCIENCES

Ferroptosis: molecular mechanisms and health implications

(2020) Daolin Tang et al.   CELL RESEARCH

Silibinin Retards Colitis-associated Carcinogenesis by Repression of Cdc25C in Mouse Model

(2019) Weiwei Li et al.   INFLAMMATORY BOWEL DISEASES

FXR Regulates Intestinal Cancer Stem Cell Proliferation

(2019) Ting Fu et al.   CELL

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Steroyl-CoA Desaturase 1 (SCD1) protects ovarian cancer cells from ferroptotic cell death

(2019) Lia Tesfay et al.   CANCER RESEARCH

Palmitic acid is an intracellular signaling molecule involved in disease development

(2019) Sarwat Fatima et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

(2019) Natalia Siwecka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High-fat diet feeding and palmitic acid increase CRC growth in β2AR-dependent manner

(2019) Sarwat Fatima et al.   Cell Death & Disease

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

(2019) Xueting Lang et al.   Cancer Discovery

RSL3 induced autophagic death in glioma cells via causing glycolysis dysfunction

(2019) Xuanzhong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis

(2019) Mara Gagliardi et al.   Cell Death & Disease

Dietary Factors Modulate Colonic Tumorigenesis Through the Interaction of Gut Microbiota and Host Chloride Channels

(2018) Yong Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Obesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment

(2018) Claudia M. Wunderlich et al.   Nature Communications

The association of diet, gut microbiota and colorectal cancer: what we eat may imply what we get

(2018) Jia Yang et al.   Protein & Cell

Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer

(2018) Daiha Shin et al.   FREE RADICAL BIOLOGY AND MEDICINE

Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor−κB, and Up-regulating Expression of MicroRNA-21

(2017) Yongzhi Yang et al.   GASTROENTEROLOGY

Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition

(2017) Matthew J. Hangauer et al.   NATURE

Alterations in neuronal control of body weight and anxiety behavior by glutathione peroxidase 4 deficiency

(2017) Sonja C. Schriever et al.   NEUROSCIENCE

Emerging Concepts Linking Obesity with the Hallmarks of Cancer

(2017) Claire L. Donohoe et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

(2016) Semir Beyaz et al.   NATURE

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Activation of mucosal mast cells promotes inflammation-related colon cancer development through recruiting and modulating inflammatory CD11b+Gr1+ cells

(2015) Lingzhi Xu et al.   CANCER LETTERS

P53-dependent miRNAs mediate nitric oxide-induced apoptosis in colonic carcinogenesis

(2015) Weiwei Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Obesity, Rather Than Diet, Drives Epigenomic Alterations in Colonic Epithelium Resembling Cancer Progression

(2014) Ruifang Li et al.   Cell Metabolism

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Role of the Gut in Lipid Homeostasis

(2012) Nada A. Abumrad et al.   PHYSIOLOGICAL REVIEWS

Effects of diet-induced obesity on colitis-associated colon tumor formation in A/J mice

(2011) S-Y Park et al.   INTERNATIONAL JOURNAL OF OBESITY

Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer

(2009) Linda A. Feagins et al.   Nature Reviews Gastroenterology & Hepatology

Aberrant Mucin Assembly in Mice Causes Endoplasmic Reticulum Stress and Spontaneous Inflammation Resembling Ulcerative Colitis

(2008) Chad K Heazlewood et al.   PLOS MEDICINE