Melatonin ameliorates neurological deficits through MT2/IL-33/ferritin H signaling-mediated inhibition of neuroinflammation and ferroptosis after traumatic brain injury

Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function

(2022) Danyang He et al.   IMMUNITY

IL-33 regulates M1/M2 chemokine expression via mitochondrial redox-related mitophagy in human monocytes

(2022) Yi-Ching Lin et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Pathologically high intraocular pressure disturbs normal iron homeostasis and leads to retinal ganglion cell ferroptosis in glaucoma

(2022) Fei Yao et al.   CELL DEATH AND DIFFERENTIATION

Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells

(2022) Yanan Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K/Akt/Nrf2/Ferritin H pathway

(2022) Ying Cheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury

(2021) Haijian Wu et al.   Journal of Neuroinflammation

Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia

(2021) Kristina G. Witcher et al.   JOURNAL OF NEUROSCIENCE

Selective Ferroptosis Inhibitor Liproxstatin-1 Attenuates Neurological Deficits and Neuroinflammation After Subarachnoid Hemorrhage

(2021) Yang Cao et al.   Neuroscience Bulletin

Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis

(2021) Nathan D. Mathewson et al.   CELL

Exosomal miR-409-3p secreted from activated mast cells promotes microglial migration, activation and neuroinflammation by targeting Nr4a2 to activate the NF-κB pathway

(2021) Liuqing Hu et al.   Journal of Neuroinflammation

Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion

(2021) Shaohe Wang et al.   CELL

Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions

(2021) Justin M. Hansen et al.   CELL

Autophagy inhibition facilitates wound closure partially dependent on the YAP/IL‐33 signaling in a mouse model of skin wound healing

(2021) Yuan Gao et al.   FASEB JOURNAL

Melatonin-mediated MT2 attenuates colitis induced by dextran sodium sulfate via PI3K/AKT/Nrf2/SIRT1/RORα/NF-κB signaling pathways

(2021) Ting Gao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3

(2021) Hao-Nan Li et al.   Journal of Neuroinflammation

FUNDC1 insufficiency sensitizes high fat diet intake-induced cardiac remodeling and contractile anomaly through ACSL4-mediated ferroptosis

(2021) Zhaohui Pei et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

(2021) Chengxian Xu et al.   Cell Reports

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

(2021) Antonia Clarissa Wehn et al.   Acta Neuropathologica Communications

Ferritin H deficiency deteriorates cellular iron handling and worsens Salmonella typhimurium infection by triggering hyperinflammation

(2021) David Haschka et al.   JCI Insight

Interleukin-33 and oxidative stress in epilepsy patients

(2021) Ozlem Ethemoglu et al.   EPILEPSY RESEARCH

A novel mechanism linking ferroptosis and endoplasmic reticulum stress via the circPtpn14/miR-351-5p/5-LOX signaling in melatonin-mediated treatment of traumatic brain injury

(2021) Chenrui Wu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects

(2021) Muhammad Zakria et al.   NEUROTOXICOLOGY

Water extract of Cayratia albifolia C.L.Li root relieves zymosan A-induced inflammation by restraining M1 macrophage polarization

(2021) Wei Li et al.   PHYTOMEDICINE

Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

(2021) Limin Wu et al.   Cell Death & Disease

Regulatory T cell is critical for interleukin-33-mediated neuroprotection against stroke

(2020) Xinjing Liu et al.   EXPERIMENTAL NEUROLOGY

Iron dyshomeostasis, lipid peroxidation and perturbed expression of cystine/glutamate antiporter in Alzheimer’s disease: Evidence of ferroptosis

(2020) Azhaar Ashraf et al.   Redox Biology

Gut microbial metabolite trimethylamine N-oxide aggravates GVHD by inducing M1 macrophage polarization in mice

(2020) Kunpeng Wu et al.   BLOOD

Deletion of H-ferritin in macrophages alleviates obesity and diabetes induced by high-fat diet in mice

(2020) Yasumasa Ikeda et al.   DIABETOLOGIA

Interleukin-33 facilitates cutaneous defense against Staphylococcus aureus by promoting the development of neutrophil extracellular trap

(2020) Xiaodi Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Hypoxia inhibits ferritinophagy, increases mitochondrial ferritin, and protects from ferroptosis

(2020) Dominik C. Fuhrmann et al.   Redox Biology

Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy

(2020) Andreas Charidimou et al.   BRAIN

Brain transforms natural killer cells that exacerbate brain edema after intracerebral hemorrhage

(2020) Zhiguo Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuroprotective effect of astrocyte-derived IL-33 in neonatal hypoxic-ischemic brain injury

(2020) Mengya Jiao et al.   Journal of Neuroinflammation

IL-33 Alleviated Brain Damage via Anti-apoptosis, Endoplasmic Reticulum Stress, and Inflammation After Epilepsy

(2020) Yuan Gao et al.   Frontiers in Neuroscience

Oesophageal squamous cell carcinoma–associated IL‐33 rewires macrophage polarization towards M2 via activating ornithine decarboxylase

(2020) Shijie Mai et al.   CELL PROLIFERATION

Deletion of ferritin H in neurons counteracts the protective effect of melatonin against traumatic brain injury‐induced ferroptosis

(2020) Tongyu Rui et al.   JOURNAL OF PINEAL RESEARCH

IL-4/STAT6 signaling facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice

(2020) Jing Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Melatonin modulates daytime-dependent synaptic plasticity and learning efficiency

(2019) Antje Jilg et al.   JOURNAL OF PINEAL RESEARCH

Role of melatonin in controlling angiogenesis under physiological and pathological conditions

(2019) Qiang Ma et al.   ANGIOGENESIS

Histological and Behavioral Evaluation after Traumatic Brain Injury in Mice: A Ten Months Follow-Up Study

(2019) Claire Leconte et al.   JOURNAL OF NEUROTRAUMA

Melatonin: A Cutaneous Perspective on its Production, Metabolism, and Functions

(2018) Andrzej T. Slominski et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization

(2018) Mei Jiang et al.   Journal of Neuroinflammation

IL-33/ST2L Signaling Provides Neuroprotection Through Inhibiting Autophagy, Endoplasmic Reticulum Stress, and Apoptosis in a Mouse Model of Traumatic Brain Injury

(2018) Yuan Gao et al.   Frontiers in Cellular Neuroscience

Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathway

(2018) Junmin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin prevents endothelial cell pyroptosis via regulation of long noncoding RNA MEG3/miR-223/NLRP3 axis

(2017) Yong Zhang et al.   JOURNAL OF PINEAL RESEARCH

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

(2017) Daniele C. Nascimento et al.   Nature Communications

MT1and MT2Melatonin Receptors: A Therapeutic Perspective

(2016) Jiabei Liu et al.   Annual Review of Pharmacology and Toxicology

Melatonin Attenuates Contrast-Induced Nephropathy in Diabetic Rats: The Role of Interleukin-33 and Oxidative Stress

(2016) Didem Onk et al.   MEDIATORS OF INFLAMMATION

IL-33 Exerts Neuroprotective Effect in Mice Intracerebral Hemorrhage Model Through Suppressing Inflammation/Apoptotic/Autophagic Pathway

(2016) Yuan Gao et al.   MOLECULAR NEUROBIOLOGY

Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury

(2016) Yoon Kyung Choi et al.   NATURE MEDICINE

IL-33-Mediated Protection against Experimental Cerebral Malaria Is Linked to Induction of Type 2 Innate Lymphoid Cells, M2 Macrophages and Regulatory T Cells

(2015) Anne-Gaelle Besnard et al.   PLoS Pathogens

Estrogenic Endocrine-Disrupting Chemicals Modulate the Production of Inflammatory Mediators and Cell Viability of Lipopolysaccharide-Stimulated Macrophages

(2014) Hyun Gyung Kim et al.   INFLAMMATION

IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice

(2014) Dong Li et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Esophagoprotection mediated by exogenous and endogenous melatonin in an experimental model of reflux esophagitis

(2013) Peter C. Konturek et al.   JOURNAL OF PINEAL RESEARCH

The inhibition of TNF-α-induced leucocyte apoptosis by melatonin involves membrane receptor MT1/MT2 interaction

(2013) Javier Espino et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice

(2012) Chang-Ming Chern et al.   FREE RADICAL BIOLOGY AND MEDICINE

Interleukin 33 Mediates Type 2 Immunity and Inflammation in the Central Nervous System of Mice Infected With Angiostrongylus cantonensis

(2012) Hui Peng et al.   JOURNAL OF INFECTIOUS DISEASES