Genetic inhibition of RIPK3 ameliorates functional outcome in controlled cortical impact independent of necroptosis

A RIPK1-regulated inflammatory microglial state in amyotrophic lateral sclerosis

(2021) Lauren Mifflin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell Death and Recovery in Traumatic Brain Injury

(2020) Yosuke Akamatsu et al.   Neurotherapeutics

Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation

(2020) Hayley I. Muendlein et al.   Cell Reports

Modeling Controlled Cortical Impact Injury in 3D Brain‐Like Tissue Cultures

(2020) Volha Liaudanskaya et al.   Advanced Healthcare Materials

Lung-derived HMGB1 is detrimental for vascular remodeling of metabolically imbalanced arterial macrophages

(2020) Ludovic Boytard et al.   Nature Communications

Cell-specific activation of RIPK1 and MLKL after intracerebral hemorrhage in mice

(2020) Sevda Lule et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

(2019) Kim Newton et al.   NATURE

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain Injury

(2019) Saef Izzy et al.   Frontiers in Cellular Neuroscience

Involvement of Alveolar Epithelial Cell Necroptosis in IPF Pathogenesis.

(2018) Ji-Min Lee et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

RIP3 deficiency protects against traumatic brain injury (TBI) through suppressing oxidative stress, inflammation and apoptosis: Dependent on AMPK pathway

(2018) Zai-Ming Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repetitive head injury in adolescent mice: A role for vascular inflammation

(2018) Limin Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Interleukin-1 receptor 1 deletion in focal and diffuse experimental traumatic brain injury in mice

(2018) Joon Yong Chung et al.   JOURNAL OF NEUROTRAUMA

Dabrafenib, an inhibitor of RIP3 kinase-dependent necroptosis, reduces ischemic brain injury

(2018) Hsiao-Huei Chen et al.   Neural Regeneration Research

HMGB1 Increases IL-1β Production in Vascular Smooth Muscle Cells via NLRP3 Inflammasome

(2018) Eun Jung Kim et al.   Frontiers in Physiology

Inhibiting of RIPK3 attenuates early brain injury following subarachnoid hemorrhage: Possibly through alleviating necroptosis

(2018) Ting Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Lack of Benefit on Brain Edema, Blood–Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury

(2018) Rajesh K. Aneja et al.   JOURNAL OF NEUROTRAUMA

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

(2018) Zhengxin Ying et al.   MOLECULAR CELL

Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases

(2018) Junying Yuan et al.   NATURE REVIEWS NEUROSCIENCE

Mechanisms of RIPK3-induced inflammation

(2017) Inbar Shlomovitz et al.   IMMUNOLOGY AND CELL BIOLOGY

Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice

(2017) Sevda Lule et al.   STROKE

RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

(2017) Kay Hänggi et al.   Cell Death & Disease

Distinct Kinase-Independent Role of RIPK3 in CD11c + Mononuclear Phagocytes in Cytokine-Induced Tissue Repair

(2017) Kenta Moriwaki et al.   Cell Reports

The danger zone: Systematic review of the role of HMGB1 danger signalling in traumatic brain injury

(2016) Taylor M. Parker et al.   BRAIN INJURY

RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury

(2016) K Newton et al.   CELL DEATH AND DIFFERENTIATION

Necroptosis-independent signaling by the RIP kinases in inflammation

(2016) Kenta Moriwaki et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4

(2016) Malek Najjar et al.   IMMUNITY

Controlled detonation: evolution of necroptosis in pathogen defense

(2016) Michelle Brault et al.   IMMUNOLOGY AND CELL BIOLOGY

Programmed Necrosis in the Cross Talk of Cell Death and Inflammation

(2015) Francis Ka-Ming Chan et al.   Annual Review of Immunology

Receptor-Interacting Protein Kinase 3 Contributes to Abdominal Aortic Aneurysms via Smooth Muscle Cell Necrosis and Inflammation

(2015) Q. Wang et al.   CIRCULATION RESEARCH

RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

(2015) Kate E. Lawlor et al.   Nature Communications

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Receptor-Interacting Protein Kinase 3 Deficiency Delays Cutaneous Wound Healing

(2015) Andrew Godwin et al.   PLoS One

RIP3 Induces Apoptosis Independent of Pronecrotic Kinase Activity

(2014) Pratyusha Mandal et al.   MOLECULAR CELL

RIPK3 as a potential therapeutic target for Gaucher's disease

(2014) Einat B Vitner et al.   NATURE MEDICINE

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Clinical correlates in an experimental model of repetitive mild brain injury

(2013) Rebekah Mannix et al.   ANNALS OF NEUROLOGY

Environmental enrichment promotes robust functional and histological benefits in female rats after controlled cortical impact injury

(2013) Christina M. Monaco et al.   EXPERIMENTAL NEUROLOGY

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

(2013) Agnieszka Kaczmarek et al.   IMMUNITY

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

(2013) James M. Murphy et al.   IMMUNITY

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

(2012) Liming Sun et al.   CELL

The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis

(2012) Jixi Li et al.   CELL

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

(2012) James E. Vince et al.   IMMUNITY

Combined inhibition of cell death induced by apoptosis inducing factor and caspases provides additive neuroprotection in experimental traumatic brain injury

(2012) Chun-Shu Piao et al.   NEUROBIOLOGY OF DISEASE

Guidelines for the Acute Medical Management of Severe Traumatic Brain Injury in Infants, Children, and Adolescents-Second Edition

(2012) &NA;   Pediatric Critical Care Medicine

Mixed lineage kinase domain-like is a key receptor interacting protein 3 downstream component of TNF-induced necrosis

(2012) J. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A novel role for RIP1 kinase in mediating TNFα production

(2012) D E Christofferson et al.   Cell Death & Disease

Neutralization of interleukin-1β reduces cerebral edema and tissue loss and improves late cognitive outcome following traumatic brain injury in mice

(2011) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice

(2011) Juyeon Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

cIAPs Block Ripoptosome Formation, a RIP1/Caspase-8 Containing Intracellular Cell Death Complex Differentially Regulated by cFLIP Isoforms

(2011) Maria Feoktistova et al.   MOLECULAR CELL

Materials fabrication from Bombyx mori silk fibroin

(2011) Danielle N Rockwood et al.   Nature Protocols

Neuronal Deletion of Caspase 8 Protects against Brain Injury in Mouse Models of Controlled Cortical Impact and Kainic Acid-Induced Excitotoxicity

(2011) Maryla Krajewska et al.   PLoS One

Tumor Necrosis Factor Alpha and Fas Receptor Contribute to Cognitive Deficits Independent of Cell Death after Concussive Traumatic Brain Injury in Mice

(2010) Jugta Khuman et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research

(2010) Carol Kilkenny et al.   PLOS BIOLOGY

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

(2009) YoungSik Cho et al.   CELL

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

(2009) Sudan He et al.   CELL

Neutralization of interleukin-1β modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice

(2009) Fredrik Clausen et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mannose Binding Lectin Gene Deficiency Increases Susceptibility to Traumatic Brain Injury in Mice

(2008) Phoebe H Yager et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Necrostatin-1 Reduces Histopathology and Improves Functional Outcome after Controlled Cortical Impact in Mice

(2008) Zerong You et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM