HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration

Ferrous but not ferric iron sulfate kills photoreceptors and induces photoreceptor-dependent RPE autofluorescence

(2020) Wanting Shu et al.   Redox Biology

Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction

(2020) Qin Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging Mechanisms and Disease Relevance of Ferroptosis

(2020) Brent R. Stockwell et al.   TRENDS IN CELL BIOLOGY

Iron is neurotoxic in retinal detachment and transferrin confers neuroprotection

(2019) Alejandra Daruich et al.   Science Advances

Ferroptosis as a target for protection against cardiomyopathy

(2019) Xuexian Fang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Ferroptosis to Iron Out Cancer

(2019) Behrouz Hassannia et al.   CANCER CELL

Cu II (atsm) inhibits ferroptosis: implications for treatment of neurodegenerative disease

(2019) Authors Adam Southon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

(2019) Andrew P. Voigt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells

(2019) Jong-Jer Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Reactive Oxygen Species and Ferroptosis in Heme-Mediated Activation of Human Platelets

(2018) Somanathapura K. NaveenKumar et al.   ACS Chemical Biology

Heme oxygenase-1 mediates BAY 11–7085 induced ferroptosis

(2018) Ling-Chu Chang et al.   CANCER LETTERS

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

Iron promotes oxidative cell death caused by bisretinoids of retina

(2018) Keiko Ueda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells

(2018) Yun Sun et al.   Cell Death & Disease

Dual effect of hemin on renal ischemia-reperfusion injury

(2018) Maxime Rossi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells

(2018) Kiyohito Totsuka et al.   EXPERIMENTAL EYE RESEARCH

Transient acceleration of autophagic degradation by pharmacological Nrf2 activation is important for retinal pigment epithelium cell survival

(2018) Yuichi Saito et al.   Redox Biology

Colony-stimulating factor 1 receptor inhibition prevents disruption of the blood-retina barrier during chronic inflammation

(2018) Despina Kokona et al.   Journal of Neuroinflammation

Mussel-inspired injectable hydrogel and its counterpart for actuating proliferation and neuronal differentiation of retinal progenitor cells

(2018) Zhimin Tang et al.   BIOMATERIALS

Characterization of ferroptosis in murine models of hemochromatosis

(2017) Hao Wang et al.   HEPATOLOGY

AIF-independent parthanatos in the pathogenesis of dry age-related macular degeneration

(2017) Ki-Hong Jang et al.   Cell Death & Disease

Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis

(2017) Seth R Flaxman et al.   Lancet Global Health

Hyperhomocysteinemia Alters Retinal Endothelial Cells Barrier Function and Angiogenic Potential via Activation of Oxidative Stress

(2017) Riyaz Mohamed et al.   Scientific Reports

Laminin modification subretinal bio-scaffold remodels retinal pigment epithelium-driven microenvironment in vitro and in vivo

(2016) Chi-Hsien Peng et al.   Oncotarget

Differences in vulnerability of neurons and astrocytes to heme oxygenase-1 modulation: Implications for mitochondrial ferritin

(2016) Xiaojun Yu et al.   Scientific Reports

RPE necroptosis in response to oxidative stress and in AMD

(2015) Jakub Hanus et al.   AGEING RESEARCH REVIEWS

Dual effects of heme oxygenase-1 on astrocyte injury induced by heminin vitro

(2015) Hao Chen et al.   BRAIN INJURY

Iron accumulation in Bruch's membrane and melanosomes of donor eyes with age-related macular degeneration

(2015) Antje Biesemeier et al.   EXPERIMENTAL EYE RESEARCH

Heme oxygenase-1 accelerates erastin-induced ferroptotic cell death

(2015) Min-Young Kwon et al.   Oncotarget

Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD

(2014) Sayak K Mitter et al.   Autophagy

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis

(2014) Wan Ling Wong et al.   Lancet Global Health

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Schizophrenia-Like Features in Transgenic Mice Overexpressing Human HO-1 in the Astrocytic Compartment

(2012) W. Song et al.   JOURNAL OF NEUROSCIENCE

Animal models of age related macular degeneration

(2012) Mark E. Pennesi et al.   MOLECULAR ASPECTS OF MEDICINE

mTOR-mediated dedifferentiation of the retinal pigment epithelium initiates photoreceptor degeneration in mice

(2010) Chen Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

(2009) Hyman M. Schipper et al.   JOURNAL OF NEUROCHEMISTRY

Zinc protoporphyrin IX, a heme oxygenase-1 inhibitor, demonstrates potent antitumor effects but is unable to potentiate antitumor effects of chemotherapeutics in mice

(2008) Dominika Nowis et al.   BMC CANCER

The homeostasis of iron and suppression of HO-1 involved in the protective effects of nimodipine on neurodegeneration induced by aluminum overloading in mice

(2008) Ye Yuan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Retinal degeneration triggered by inactivation of PTEN in the retinal pigment epithelium

(2008) J. W. Kim et al.   GENES & DEVELOPMENT