The New Microtubule-Targeting Agent SIX2G Induces Immunogenic Cell Death in Multiple Myeloma

Immunogenic cell stress and death

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Therapeutic afucosylated monoclonal antibody and bispecific T-cell engagers for T-cell acute lymphoblastic leukemia

(2021) Daniele Caracciolo et al.   Journal for ImmunoTherapy of Cancer

miRNAs and lncRNAs as Novel Therapeutic Targets to Improve Cancer Immunotherapy

(2021) Maria Teresa Di Martino et al.   Cancers

Overcoming the Immunosuppressive Tumor Microenvironment in Multiple Myeloma

(2021) Fatih M. Uckun   Cancers

Harnessing the Immune System to Fight Multiple Myeloma

(2021) Jakub Krejcik et al.   Cancers

miR-22 Modulates Lenalidomide Activity by Counteracting MYC Addiction in Multiple Myeloma

(2021) Daniele Caracciolo et al.   Cancers

From Immunogenic Cell Death to Immunogenic Modulation: Select Chemotherapy Regimens Induce a Spectrum of Immune-Enhancing Activities in the Tumor Microenvironment

(2021) Kellsye P. Fabian et al.   Frontiers in Oncology

Second-Generation Antimitotics in Cancer Clinical Trials

(2021) Pedro Novais et al.   Pharmaceutics

Advancing to the era of cancer immunotherapy

(2021) Yun Wang et al.   Cancer Communications

Microtubule Targeting Agents in Disease: Classic Drugs, Novel Roles

(2021) Linda Wordeman et al.   Cancers

Exploiting MYC-induced PARPness to target genomic instability in multiple myeloma

(2020) Daniele Caracciolo et al.   HAEMATOLOGICA

Microtubule-targeting agents and their impact on cancer treatment

(2020) Vladimír Čermák et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Exploiting immune-dependent effects of microtubule-targeting agents to improve efficacy and tolerability of cancer treatment

(2020) Angela Flavia Serpico et al.   Cell Death & Disease

Consensus guidelines for the definition, detection and interpretation of immunogenic cell death

(2020) Lorenzo Galluzzi et al.   Journal for ImmunoTherapy of Cancer

Cancer immunoediting and immune dysregulation in multiple myeloma

(2020) Kyohei Nakamura et al.   BLOOD

Error‐prone DNA repair pathways as determinants of immunotherapy activity: an emerging scenario for cancer treatment

(2020) Daniele Caracciolo et al.   INTERNATIONAL JOURNAL OF CANCER

An overview on anti-tubulin agents for the treatment of lymphoma patients

(2020) Marilia Barreca et al.   PHARMACOLOGY & THERAPEUTICS

Evaluation of [1,2]oxazolo[5,4-e]isoindoles in lymphoma cells

(2020) M. Barreca et al.   EUROPEAN JOURNAL OF CANCER

Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types

(2020) Virginia Spanò et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Potential of Combining Tubulin-Targeting Anticancer Therapeutics and Immune Therapy

(2019) Alexis Fong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunogenic cell death in cancer therapy: Present and emerging inducers

(2019) Jingyi Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition

(2019) Xionghao Lin et al.   Frontiers in Microbiology

eIF2α phosphorylation is pathognomonic for immunogenic cell death

(2018) Lucillia Bezu et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

OUP accepted manuscript

(2018)   JOURNAL OF INFECTIOUS DISEASES

Discovery of a Novel Microtubule Targeting Agent as an Adjuvant for Cancer Immunotherapy

(2018) Fumi Sato-Kaneko et al.   Biomed Research International

[1,2]Oxazolo[5,4- e ]isoindoles as promising tubulin polymerization inhibitors

(2016) Virginia Spanò et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Preclinical Activity of New [1,2]Oxazolo[5,4-e]isoindole Derivatives in Diffuse Malignant Peritoneal Mesothelioma

(2016) Virginia Spanò et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth

(2016) María-Jesús Pérez-Pérez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Promising therapies in multiple myeloma

(2015) G. Bianchi et al.   BLOOD

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase

(2015) Meng S. Choy et al.   Cell Reports

The pharmacological bases of the antiangiogenic activity of paclitaxel

(2013) Guido Bocci et al.   ANGIOGENESIS

Mechanisms of inhibition of endothelial cell migration by taxanes

(2013) Kathy Kamath et al.   Cytoskeleton

Synthesis and Antiproliferative Activity of the Ring System [1,2]Oxazolo[4,5-g]indole

(2012) Paola Barraja et al.   ChemMedChem

Molecular Targets for the Treatment of Multiple Myeloma

(2012) Marco Rossi et al.   CURRENT CANCER DRUG TARGETS

Improving the Prediction of Absolute Solvation Free Energies Using the Next Generation OPLS Force Field

(2012) Devleena Shivakumar et al.   Journal of Chemical Theory and Computation

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site

(2012) Yan Lu et al.   PHARMACEUTICAL RESEARCH

Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1

(2012) Tatiana Ammosova et al.   PLoS One

Disruption of the PP1/GADD34 complex induces calreticulin exposure

(2011) Oliver Kepp et al.   CELL CYCLE

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

(2010) L. Zitvogel et al.   CLINICAL CANCER RESEARCH

Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites

(2010) Michael J Ragusa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Janus kinase inhibitor INCB20 has antiproliferative and apoptotic effects on human myeloma cells in vitro and in vivo

(2009) R. Burger et al.   MOLECULAR CANCER THERAPEUTICS

Crystal Structures of Protein Phosphatase-1 Bound to Nodularin-R and Tautomycin: A Novel Scaffold for Structure-based Drug Design of Serine/Threonine Phosphatase Inhibitors

(2008) Matthew S. Kelker et al.   JOURNAL OF MOLECULAR BIOLOGY