1,2,4-Triazolo[1,5-a]pyrimidines: Efficient one-step synthesis and functionalization as influenza polymerase PA-PB1 interaction disruptors

1,2,4-Triazolo[1,5-a]pyrimidines as a Novel Class of Inhibitors of the HIV-1 Reverse Transcriptase-Associated Ribonuclease H Activity

(2020) Jenny Desantis et al.   MOLECULES

Next-generation direct-acting influenza therapeutics

(2020) Mart Toots et al.   Translational Research

Structure and Function of Influenza Polymerase

(2020) Joanna M. Wandzik et al.   Cold Spring Harbor Perspectives in Medicine

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

(2020) Serena Massari et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

(2020) Robbert Boudewijns et al.   Nature Communications

An exhaustive compilation on chemistry of triazolopyrimidine: A journey through decades

(2019) Pankaj Kumar Singh et al.   BIOORGANIC CHEMISTRY

Antivirals targeting the polymerase complex of influenza viruses

(2019) Edin J. Mifsud et al.   ANTIVIRAL RESEARCH

Structure and Function of the Influenza Virus Transcription and Replication Machinery

(2019) Ervin Fodor et al.   Cold Spring Harbor Perspectives in Medicine

Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development

(2018) Jiantao Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Recent Applications of Triazolopyrimidine-Based Bioactive Compounds in Medicinal and Agrochemical Chemistry

(2018) Qu Renyu et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

A Parallel Approach to 7-(Hetero)arylpyrazolo[1,5-a]pyrimidin-5-ones

(2018) Daniel C. Schmitt et al.   ACS Combinatorial Science

Synthetic Versatility of β-Alkoxyvinyl Trichloromethyl Ketones for Obtaining [1,2,4]Triazolo[1,5-a]pyrimidines

(2018) Nilo Zanatta et al.   SYNTHESIS-STUTTGART

In vitro characterization of baloxavir acid, a first-in-class cap-dependent endonuclease inhibitor of the influenza virus polymerase PA subunit

(2018) Takeshi Noshi et al.   ANTIVIRAL RESEARCH

Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors

(2018) Carlos J.A. Ribeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial

(2018) Robert W Finberg et al.   JOURNAL OF INFECTIOUS DISEASES

Efficient and regioselective one-step synthesis of 7-aryl-5-methyl- and 5-aryl-7-methyl-2-amino-[1,2,4]triazolo[1,5-a]pyrimidine derivatives

(2017) Serena Massari et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Simple access toward 3-halo- and 3-nitro-pyrazolo[1,5-a]pyrimidines through a one-pot sequence

(2017) Juan-Carlos Castillo et al.   RSC Advances

A Novel Endonuclease Inhibitor Exhibits Broad-Spectrum Anti-Influenza Virus ActivityIn Vitro

(2016) Jeremy C. Jones et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polymerase Acidic Protein–Basic Protein 1 (PA–PB1) Protein–Protein Interaction as a Target for Next-Generation Anti-influenza Therapeutics

(2016) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Broad Anti-influenza Hybrid Small Molecule That Potently Disrupts the Interaction of Polymerase Acidic Protein–Basic Protein 1 (PA-PB1) Subunits

(2015) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Triazolopyridines as Selective JAK1 Inhibitors: From Hit Identification to GLPG0634

(2014) Christel J. Menet et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2

(2014) Michael P. Clark et al.   JOURNAL OF MEDICINAL CHEMISTRY

Favipiravir (T-705), a novel viral RNA polymerase inhibitor

(2013) Yousuke Furuta et al.   ANTIVIRAL RESEARCH

Structural Investigation of Cycloheptathiophene-3-carboxamide Derivatives Targeting Influenza Virus Polymerase Assembly

(2013) Serena Massari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Human Cytomegalovirus Inhibitor AL18 Also Possesses Activity against Influenza A and B Viruses

(2012) Giulia Muratore et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A novel method for high-throughput screening to quantify antiviral activity against viruses that induce limited CPE

(2012) Dirk Jochmans et al.   JOURNAL OF VIROLOGICAL METHODS

Small molecule inhibitors of influenza A and B viruses that act by disrupting subunit interactions of the viral polymerase

(2012) G. Muratore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiviral Agents for the Treatment and Chemoprophylaxis of Influenza

(2011)   ANNALS OF EMERGENCY MEDICINE

Disruption of the Viral Polymerase Complex Assembly as a Novel Approach to Attenuate Influenza A Virus

(2010) Benjamin Mänz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design of tRNALys3Ligands: Fragment Evolution and Linker Selection Guided by NMR Spectroscopy

(2009) Florence Chung et al.   CHEMISTRY-A EUROPEAN JOURNAL

Crystal structure of the polymerase PAC–PB1N complex from an avian influenza H5N1 virus

(2008) Xiaojing He et al.   NATURE