Highlighting vulnerabilities in the alternative lengthening of telomeres pathway

ATRX loss in glioma results in dysregulation of cell-cycle phase transition and ATM inhibitor radio-sensitization

(2022) Tingting Qin et al.   Cell Reports

Telomeric replication stress: the beginning and the end for alternative lengthening of telomeres cancers

(2022) Robert Lu et al.   Open Biology

RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination

(2022) Platon Selemenakis et al.   Frontiers in Cell and Developmental Biology

Alternative Lengthening of Telomeres in Cancer Confers a Vulnerability to Reactivation of p53 Function

(2022) Shawn J. Macha et al.   CANCER RESEARCH

TOP3A amplification and ATRX inactivation are mutually exclusive events in pediatric osteosarcomas using ALT

(2022) Alexandre de Nonneville et al.   EMBO Molecular Medicine

Guiding ATR and PARP inhibitor combinations with chemogenomic screens

(2022) Michal Zimmermann et al.   Cell Reports

Therapeutic Vulnerability to ATR Inhibition in Concurrent NF1 and ATRX-Deficient/ALT-Positive High-Grade Solid Tumors

(2022) Ming Yuan et al.   Cancers

TERRA and RAD51AP1 promote alternative lengthening of telomeres through an R- to D-loop switch

(2022) Tribhuwan Yadav et al.   MOLECULAR CELL

Alternative lengthening of telomeres is a self-perpetuating process in ALT-associated PML bodies

(2021) Jia-Min Zhang et al.   MOLECULAR CELL

Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX

(2021) Alexandre de Nonneville et al.   Nature Communications

ALT Positivity in Human Cancers: Prevalence and Clinical Insights

(2021) Danny MacKenzie et al.   Cancers

SMARCAL1 loss and alternative lengthening of telomeres (ALT) are enriched in giant cell glioblastoma

(2021) Jacqueline A. Brosnan-Cashman et al.   MODERN PATHOLOGY

ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156

(2021) Balakrishna Koneru et al.   Science Translational Medicine

Loss of ATRX confers DNA repair defects and PARP inhibitor sensitivity

(2021) Jennifer Garbarino et al.   Translational Oncology

TERRA transcription destabilizes telomere integrity to initiate break-induced replication in human ALT cells

(2021) Bruno Silva et al.   Nature Communications

Anti-recombination function of MutSα restricts telomere extension by ALT-associated homology-directed repair

(2021) Jonathan Barroso-González et al.   Cell Reports

Telomere maintenance mechanisms in cancer: telomerase, ALT or lack thereof

(2020) Eloïse Claude et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Genomic footprints of activated telomere maintenance mechanisms in cancer

(2020) Lina Sieverling et al.   Nature Communications

MYCN amplification and ATRX mutations are incompatible in neuroblastoma

(2020) Maged Zeineldin et al.   Nature Communications

RAD54 promotes alternative lengthening of telomeres by mediating branch migration

(2020) Emily Mason‐Osann et al.   EMBO REPORTS

Regulation of ALT-associated homology-directed repair by polyADP-ribosylation

(2020) Song My Hoang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma

(2020) Sally L George et al.   EBioMedicine

Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

(2019) Jia-Min Zhang et al.   Cell Reports

RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening

(2019) Priyanka Verma et al.   GENES & DEVELOPMENT

Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

(2019) Jaewon Min et al.   GENES & DEVELOPMENT

TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1

(2019) Harikleia Episkopou et al.   MOLECULAR CELL

The FANCM-BLM-TOP3A-RMI complex suppresses alternative lengthening of telomeres (ALT)

(2019) Robert Lu et al.   Nature Communications

FANCM limits ALT activity by restricting telomeric replication stress induced by deregulated BLM and R-loops

(2019) Bruno Silva et al.   Nature Communications

Genome-wide CRISPR-Cas9 screen reveals selective vulnerability of ATRX-mutant cancers to WEE1 inhibition

(2019) Junbo Liang et al.   CANCER RESEARCH

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

(2019) Jonathan Barroso-González et al.   MOLECULAR CELL

SLX4IP Antagonizes Promiscuous BLM Activity during ALT Maintenance

(2019) Stephanie Panier et al.   MOLECULAR CELL

FANCM suppresses DNA replication stress at ALT telomeres by disrupting TERRA R-loops

(2019) Xiaolei Pan et al.   Scientific Reports

Telomere Loop Dynamics in Chromosome End Protection

(2018) David Van Ly et al.   MOLECULAR CELL

The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma

(2018) Bill H. Diplas et al.   Nature Communications

Shelterin-Mediated Telomere Protection

(2018) Titia de Lange   Annual Review of Genetics

Highly Aggressive Metastatic Melanoma Cells Unable to Maintain Telomere Length

(2017) Nikenza Viceconte et al.   Cell Reports

Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres

(2017) Rebecca A. Dagg et al.   Cell Reports

Break-induced telomere synthesis underlies alternative telomere maintenance

(2016) Robert L. Dilley et al.   NATURE

SMARCAL1 Resolves Replication Stress at ALT Telomeres

(2016) Kelli E. Cox et al.   Cell Reports

Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition

(2016) Katharina I. Deeg et al.   Frontiers in Oncology

Suppression of the alternative lengthening of telomere pathway by the chromatin remodelling factor ATRX

(2015) David Clynes et al.   Nature Communications

Interchromosomal Homology Searches Drive Directional ALT Telomere Movement and Synapsis

(2014) Nam Woo Cho et al.   CELL

RNaseH1 regulates TERRA-telomeric DNA hybrids and telomere maintenance in ALT tumour cells

(2014) Rajika Arora et al.   Nature Communications

Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells

(2012) Dimitri Conomos et al.   JOURNAL OF CELL BIOLOGY

Human telomeres replicate using chromosome-specific, rather than universal, replication programs

(2012) William C. Drosopoulos et al.   JOURNAL OF CELL BIOLOGY

Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

(2011) Christopher M. Heaphy et al.   AMERICAN JOURNAL OF PATHOLOGY

Altered Telomeres in Tumors with ATRX and DAXX Mutations

(2011) C. M. Heaphy et al.   SCIENCE

Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions

(2010) Aaron D. Goldberg et al.   CELL

Alternative lengthening of telomeres: models, mechanisms and implications

(2010) Anthony J. Cesare et al.   NATURE REVIEWS GENETICS

Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

(2010) P. W. Lewis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks

(2009) C. E. Bansbach et al.   GENES & DEVELOPMENT

DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

(2009) Jeremy D Henson et al.   NATURE BIOTECHNOLOGY