RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous Recombination

Alternate therapeutic pathways for PARP inhibitors and potential mechanisms of resistance

(2021) Dae-Seok Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Single-molecule analysis reveals cooperative stimulation of Rad51 filament nucleation and growth by mediator proteins

(2021) Ondrej Belan et al.   MOLECULAR CELL

The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination

(2021) Upasana Roy et al.   MOLECULAR CELL

RNA transcripts stimulate homologous recombination by forming DR-loops

(2021) Jian Ouyang et al.   NATURE

The emerging determinants of replication fork stability

(2021) Tanay Thakar et al.   NUCLEIC ACIDS RESEARCH

RAD51AP1 mediates RAD51 activity through nucleosome interaction

(2021) Elena Pires et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication gaps are a key determinant of PARP inhibitor synthetic lethality with BRCA deficiency

(2021) Ke Cong et al.   MOLECULAR CELL

RAD54 promotes alternative lengthening of telomeres by mediating branch migration

(2020) Emily Mason‐Osann et al.   EMBO REPORTS

The Role of Alternative Lengthening of Telomeres Mechanism in Cancer: Translational and Therapeutic Implications

(2020) Marta Recagni et al.   Cancers

RAD51AP1 deficiency reduces tumor growth by targeting stem cell self-renewal

(2020) Allison E. Bridges et al.   CANCER RESEARCH

A Genetic Map of the Response to DNA Damage in Human Cells

(2020) Michele Olivieri et al.   CELL

Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination

(2020) J. Brooks Crickard et al.   CELL

NUCKS1 promotes RAD54 activity in homologous recombination DNA repair

(2020) David G. Maranon et al.   JOURNAL OF CELL BIOLOGY

RAD51AP1 promotes progression of ovarian cancer via TGF‐β/Smad signalling pathway

(2020) Hongyu Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PrimPol-dependent single-stranded gap formation mediates homologous recombination at bulky DNA adducts

(2020) Ann Liza Piberger et al.   Nature Communications

New Perspectives for Resistance to PARP Inhibitors in Triple-Negative Breast Cancer

(2020) Ye Han et al.   Frontiers in Oncology

DNA requirement in FANCD2 deubiquitination by USP1-UAF1-RAD51AP1 in the Fanconi anemia DNA damage response

(2019) Fengshan Liang et al.   Nature Communications

RAD51AP1 Is an Essential Mediator of Alternative Lengthening of Telomeres

(2019) Jonathan Barroso-González et al.   MOLECULAR CELL

Harnessing DNA Double-Strand Break Repair for Cancer Treatment

(2019) Anika Trenner et al.   Frontiers in Oncology

DNA Double Strand Breaks Repair Inhibitors: Relevance as Potential New Anticancer Therapeutics

(2018) Paulina Kopa et al.   CURRENT MEDICINAL CHEMISTRY

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

Identification of an eight-gene prognostic signature for lung adenocarcinoma

(2018) Shicheng Li et al.   Cancer Management and Research

Restoration of Replication Fork Stability in BRCA1- and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers

(2017) Angelo Taglialatela et al.   MOLECULAR CELL

BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

(2017) Weixing Zhao et al.   NATURE

Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

(2017) Likun Li et al.   Science Signaling

MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells

(2017) Delphine Lemaçon et al.   Nature Communications

Replication fork reversal triggers fork degradation in BRCA2-defective cells

(2017) Sofija Mijic et al.   Nature Communications

Androgen receptor inhibitor–induced “BRCAness” and PARP inhibition are synthetically lethal for castration-resistant prostate cancer

(2017) Likun Li et al.   Science Signaling

Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth

(2016) R. Pathania et al.   CANCER RESEARCH

Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability

(2016) Julian Spies et al.   MOLECULAR CELL

The Tumor-Associated Variant RAD51 G151D Induces a Hyper-Recombination Phenotype

(2016) Carolyn G. Marsden et al.   PLoS Genetics

Biochemical mechanism of DSB end resection and its regulation

(2015) James M. Daley et al.   DNA REPAIR

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry

(2015) Weixing Zhao et al.   MOLECULAR CELL

NUCKS1 is a novel RAD51AP1 paralog important for homologous recombination and genome stability

(2015) Ann C. Parplys et al.   NUCLEIC ACIDS RESEARCH

RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells

(2015) Jennifer M. Mason et al.   NUCLEIC ACIDS RESEARCH

RAD51AP1 -deficiency in vertebrate cells impairs DNA replication

(2014) Ann C. Parplys et al.   DNA REPAIR

End Resection at Double-Strand Breaks: Mechanism and Regulation

(2014) L. S. Symington   Cold Spring Harbor Perspectives in Biology

Mechanistic Insights into RAD51-associated Protein 1 (RAD51AP1) Action in Homologous DNA Repair

(2012) Myun Hwa Dunlop et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination

(2011) Shannon J. Ceballos et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells

(2010) P. Gottipati et al.   CANCER RESEARCH

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2

(2010) Eloïse Dray et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cooperation of RAD51 and RAD54 in regression of a model replication fork

(2010) Dmitry V. Bugreev et al.   NUCLEIC ACIDS RESEARCH

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Specific synthetic lethal killing of RAD54B-deficient human colorectal cancer cells by FEN1 silencing

(2009) K. J. McManus et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhanced Expression of RAD51 Associating Protein-1 Is Involved in the Growth of Intrahepatic Cholangiocarcinoma Cells

(2008) K. Obama et al.   CLINICAL CANCER RESEARCH

The consequences of Rad51 overexpression for normal and tumor cells

(2008) Hannah L. Klein   DNA REPAIR

RAD54 controls access to the invading 3′-OH end after RAD51-mediated DNA strand invasion in homologous recombination in Saccharomyces cerevisiae

(2008) Xuan Li et al.   NUCLEIC ACIDS RESEARCH