Metastasis

Outcomes and clinicopathologic characteristics associated with disseminated tumor cells in bone marrow after neoadjuvant chemotherapy in high-risk early stage breast cancer: the I-SPY SURMOUNT study

(2023) Mark Jesus M. Magbanua et al.   BREAST CANCER RESEARCH AND TREATMENT

Slow TCA flux and ATP production in primary solid tumours but not metastases

(2023) Caroline R. Bartman et al.   NATURE

The next generation of evidence-based medicine

(2023) Vivek Subbiah   NATURE MEDICINE

Humanized mouse models for immuno-oncology research

(2023) Jane Chuprin et al.   Nature Reviews Clinical Oncology

Engineering the Immune Microenvironment into Organoid Models

(2023) Kathleen A. Luckett et al.   Annual Review of Cancer Biology-Series

Epigenetics as a mediator of plasticity in cancer

(2023) Andrew P. Feinberg et al.   SCIENCE

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

(2022) Bastien Nguyen et al.   CELL

Cellular architecture of human brain metastases

(2022) Hugo Gonzalez et al.   CELL

Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer

(2022) Peter Schmid et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hallmarks of Cancer: New Dimensions

(2022) Douglas Hanahan   Cancer Discovery

Immune phenotypic linkage between colorectal cancer and liver metastasis

(2022) Yedan Liu et al.   CANCER CELL

Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

(2022) Nathan E. Reticker-Flynn et al.   CELL

Spatial CRISPR genomics identifies regulators of the tumor microenvironment

(2022) Maxime Dhainaut et al.   CELL

Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution

(2022) Dian Yang et al.   CELL

Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer

(2022) Aikun Fu et al.   CELL

Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche

(2022) Pilar Baldominos et al.   CELL

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

(2022) Matteo Rossi et al.   NATURE

Neoantigen quality predicts immunoediting in survivors of pancreatic cancer

(2022) Marta Łuksza et al.   NATURE

Stromal changes in the aged lung induce an emergence from melanoma dormancy

(2022) Mitchell E. Fane et al.   NATURE

Targeting the gut and tumor microbiota in cancer

(2022) Elizabeth M. Park et al.   NATURE MEDICINE

RNA-binding proteins and cancer metastasis

(2022) Shengjie Wang et al.   SEMINARS IN CANCER BIOLOGY

Reflected stemness as a potential driver of the tumour microenvironment

(2022) Felipe S. Rodrigues et al.   TRENDS IN CELL BIOLOGY

Dissecting the treatment-naive ecosystem of human melanoma brain metastasis

(2022) Jana Biermann et al.   CELL

The metastatic spread of breast cancer accelerates during sleep

(2022) Zoi Diamantopoulou et al.   NATURE

Cell–matrix interface regulates dormancy in human colon cancer stem cells

(2022) Yuki Ohta et al.   NATURE

A time-resolved, multi-symbol molecular recorder via sequential genome editing

(2022) Junhong Choi et al.   NATURE

Mitochondrial RNA modifications shape metabolic plasticity in metastasis

(2022) Sylvain Delaunay et al.   NATURE

The oligometastatic spectrum in the era of improved detection and modern systemic therapy

(2022) Rohan R. Katipally et al.   Nature Reviews Clinical Oncology

Pembrolizumab plus Chemotherapy in Advanced Triple-Negative Breast Cancer

(2022) Javier Cortes et al.   NEW ENGLAND JOURNAL OF MEDICINE

A cellular hierarchy in melanoma uncouples growth and metastasis

(2022) Panagiotis Karras et al.   NATURE

Insights and opportunities at the crossroads of cancer and neuroscience

(2022) Chenchen Pan et al.   NATURE CELL BIOLOGY

The NALCN channel regulates metastasis and nonmalignant cell dissemination

(2022) Eric P. Rahrmann et al.   NATURE GENETICS

Clinical implications of T cell exhaustion for cancer immunotherapy

(2022) Andrew Chow et al.   Nature Reviews Clinical Oncology

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

(2022) Joseph M. Chan et al.   SCIENCE

Metastatic recurrence in colorectal cancer arises from residual EMP1+ cells

(2022) Adrià Cañellas-Socias et al.   NATURE

Spatial genomics maps the structure, nature and evolution of cancer clones

(2022) Artem Lomakin et al.   NATURE

Dendritic cells direct circadian anti-tumour immune responses

(2022) Chen Wang et al.   NATURE

MacroH2A impedes metastatic growth by enforcing a discrete dormancy program in disseminated cancer cells

(2022) Dan Sun et al.   Science Advances

Two isoleucyl tRNAs that decode synonymous codons divergently regulate breast cancer metastatic growth by controlling translation of proliferation-regulating genes

(2022) Lisa B. Earnest-Noble et al.   Nature Cancer

Targeting metastatic cancer

(2021) Karuna Ganesh et al.   NATURE MEDICINE

Single-cell lineages reveal the rates, routes, and drivers of metastasis in cancer xenografts

(2021) Jeffrey J. Quinn et al.   SCIENCE

Tissue regeneration: Reserve or reverse?

(2021) Ramesh A. Shivdasani et al.   SCIENCE

The bone microenvironment invigorates metastatic seeds for further dissemination

(2021) Weijie Zhang et al.   CELL

The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

(2021) Igor L. Bado et al.   DEVELOPMENTAL CELL

A prometastatic splicing program regulated by SNRPA1 interactions with structured RNA elements

(2021) Lisa Fish et al.   SCIENCE

Metastasis-Initiating Cells and Ecosystems

(2021) Joan Massagué et al.   Cancer Discovery

Therapeutic Targeting of the Tumor Microenvironment

(2021) Leire Bejarano et al.   Cancer Discovery

Tumor organoids: Opportunities and challenges to guide precision medicine

(2021) Vivien Veninga et al.   CANCER CELL

Single-cell lineage tracing of metastatic cancer reveals selection of hybrid EMT states

(2021) Kamen P. Simeonov et al.   CANCER CELL

Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level

(2021) Yingcheng Wu et al.   Cancer Discovery

MYC levels regulate metastatic heterogeneity in pancreatic adenocarcinoma

(2021) Ravikanth Maddipati et al.   Cancer Discovery

Tumor-draining lymph nodes: At the crossroads of metastasis and immunity

(2021) Haley du Bois et al.   Science Immunology

Dietary palmitic acid promotes a prometastatic memory via Schwann cells

(2021) Gloria Pascual et al.   NATURE

Redox Regulation in Cancer Cells during Metastasis

(2021) Alpaslan Tasdogan et al.   Cancer Discovery

Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels

(2021) Isabel Kurth et al.   Science Advances

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

(2020) Eric C. Cheung et al.   CANCER CELL

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

(2020) Ashley M. Laughney et al.   NATURE MEDICINE

Writers, readers and erasers of RNA modifications in cancer

(2020) Rosaura Esteve-Puig et al.   CANCER LETTERS

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

(2020) Orit Rozenblatt-Rosen et al.   CELL

Single-Cell Mapping of Human Brain Cancer Reveals Tumor-Specific Instruction of Tissue-Invading Leukocytes

(2020) Ekaterina Friebel et al.   CELL

Interrogation of the Microenvironmental Landscape in Brain Tumors Reveals Disease-Specific Alterations of Immune Cells

(2020) Florian Klemm et al.   CELL

Plasticity of Lgr5-Negative Cancer Cells Drives Metastasis in Colorectal Cancer

(2020) Arianna Fumagalli et al.   Cell Stem Cell

Multi-cancer analysis of clonality and the timing of systemic spread in paired primary tumors and metastases

(2020) Zheng Hu et al.   NATURE GENETICS

Lymph node metastases develop through a wider evolutionary bottleneck than distant metastases

(2020) Johannes G. Reiter et al.   NATURE GENETICS

Common germline variants of the human APOE gene modulate melanoma progression and survival

(2020) Benjamin N. Ostendorf et al.   NATURE MEDICINE

Lineage plasticity in cancer: a shared pathway of therapeutic resistance

(2020) Álvaro Quintanal-Villalonga et al.   Nature Reviews Clinical Oncology

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The human tumor microbiome is composed of tumor type–specific intracellular bacteria

(2020) Deborah Nejman et al.   SCIENCE

Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

(2020) Lindsay M. LaFave et al.   CANCER CELL

Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

(2020) Nemanja Despot Marjanovic et al.   CANCER CELL

Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration

(2020) Jinwook Choi et al.   Cell Stem Cell

Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis

(2020) Yoshihiko Kobayashi et al.   NATURE CELL BIOLOGY

Looking backward in time to define the chronology of metastasis

(2020) Zheng Hu et al.   Nature Communications

Lymph protects metastasizing melanoma cells from ferroptosis

(2020) Jessalyn M. Ubellacker et al.   NATURE

Plasticity of ether lipids promotes ferroptosis susceptibility and evasion

(2020) Yilong Zou et al.   NATURE

Pervasive chromosomal instability and karyotype order in tumour evolution

(2020) Thomas B. K. Watkins et al.   NATURE

Integrating genetic and non-genetic determinants of cancer evolution by single-cell multi-omics

(2020) Anna S. Nam et al.   NATURE REVIEWS GENETICS

YTHDF3 Induces the Translation of m6A-Enriched Gene Transcripts to Promote Breast Cancer Brain Metastasis

(2020) Guoqiang Chang et al.   CANCER CELL

Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis

(2020) Ievgenia Pastushenko et al.   NATURE

A metastasis map of human cancer cell lines

(2020) Xin Jin et al.   NATURE

Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation

(2019) Choong-kun Lee et al.   SCIENCE

Hepatocytes direct the formation of a pro-metastatic niche in the liver

(2019) Jae W. Lee et al.   NATURE

Lineage Tracing in Humans Enabled by Mitochondrial Mutations and Single-Cell Genomics

(2019) Leif S. Ludwig et al.   CELL

Metastasis Organotropism: Redefining the Congenial Soil

(2019) Yang Gao et al.   DEVELOPMENTAL CELL

Exosome-Mediated Metastasis: Communication from a Distance

(2019) Inbal Wortzel et al.   DEVELOPMENTAL CELL

Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non–Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study

(2019) Daniel R. Gomez et al.   JOURNAL OF CLINICAL ONCOLOGY

ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression

(2019) Feven Tameire et al.   NATURE CELL BIOLOGY

Quantitative evidence for early metastatic seeding in colorectal cancer

(2019) Zheng Hu et al.   NATURE GENETICS

Metastasis as a systemic disease: molecular insights and clinical implications

(2019) Maša Alečković et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Stereotactic ablative radiotherapy for the comprehensive treatment of 4–10 oligometastatic tumors (SABR-COMET-10): study protocol for a randomized phase III trial

(2019) David A. Palma et al.   BMC CANCER

E-cadherin is required for metastasis in multiple models of breast cancer

(2019) Veena Padmanaban et al.   NATURE

Cell Clustering Promotes a Metabolic Switch that Supports Metastatic Colonization

(2019) Christiaan F. Labuschagne et al.   Cell Metabolism

Pan-cancer whole-genome analyses of metastatic solid tumours

(2019) Peter Priestley et al.   NATURE

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

The great escape: tumour cell plasticity in resistance to targeted therapy

(2019) Soufiane Boumahdi et al.   NATURE REVIEWS DRUG DISCOVERY

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization

(2018) Tanya Schild et al.   CANCER CELL

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

Asparagine bioavailability governs metastasis in a model of breast cancer

(2018) Simon R. V. Knott et al.   NATURE

Chromosomal instability drives metastasis through a cytosolic DNA response

(2018) Samuel F. Bakhoum et al.   NATURE

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

(2018) Arnaud Pommier et al.   SCIENCE

Autophagy Sustains Pancreatic Cancer Growth through Both Cell-Autonomous and Nonautonomous Mechanisms

(2018) Annan Yang et al.   Cancer Discovery

Immunological differences between primary and metastatic breast cancer

(2018) B Szekely et al.   ANNALS OF ONCOLOGY

The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers

(2018) Pedram Razavi et al.   CANCER CELL

Epigenetic and Transcriptomic Profiling of Mammary Gland Development and Tumor Models Disclose Regulators of Cell State Plasticity

(2018) Christopher Dravis et al.   CANCER CELL

Identification of the tumour transition states occurring during EMT

(2018) Ievgenia Pastushenko et al.   NATURE

Minimal functional driver gene heterogeneity among untreated metastases

(2018) Johannes G. Reiter et al.   SCIENCE

Phenotypic Plasticity: Driver of Cancer Initiation, Progression, and Therapy Resistance

(2018) Piyush B. Gupta et al.   Cell Stem Cell

Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility

(2018) Amanpreet Kaur et al.   Cancer Discovery

A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer

(2017) Felipe de Sousa e Melo et al.   NATURE

Obesity alters the lung myeloid cell landscape to enhance breast cancer metastasis through IL5 and GM-CSF

(2017) Daniela F. Quail et al.   NATURE CELL BIOLOGY

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years

(2017) Hongchao Pan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Origins of lymphatic and distant metastases in human colorectal cancer

(2017) Kamila Naxerova et al.   SCIENCE

Analysis ofFusobacteriumpersistence and antibiotic response in colorectal cancer

(2017) Susan Bullman et al.   SCIENCE

Metastatic disease from uveal melanoma: treatment options and future prospects

(2016) Richard D Carvajal et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Modulated Expression of Specific tRNAs Drives Gene Expression and Cancer Progression

(2016) Hani Goodarzi et al.   CELL

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Early dissemination seeds metastasis in breast cancer

(2016) Hedayatollah Hosseini et al.   NATURE

Targeting metastasis-initiating cells through the fatty acid receptor CD36

(2016) Gloria Pascual et al.   NATURE

Mechanism of early dissemination and metastasis in Her2+ mammary cancer

(2016) Kathryn L. Harper et al.   NATURE

Metastasis as an evolutionary process

(2016) S. Turajlic et al.   SCIENCE

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Stromal-Initiated Changes in the Bone Promote Metastatic Niche Development

(2016) Xianmin Luo et al.   Cell Reports

Extracellular Metabolic Energetics Can Promote Cancer Progression

(2015) Jia Min Loo et al.   CELL

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Detection of Circulating Pancreas Epithelial Cells in Patients With Pancreatic Cystic Lesions

(2013) Andrew D. Rhim et al.   GASTROENTEROLOGY

Liver resection for metastatic melanoma: Equivalent survival for cutaneous and ocular primaries

(2013) Seung Wook Ryu et al.   JOURNAL OF SURGICAL ONCOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Alpha Emitter Radium-223 and Survival in Metastatic Prostate Cancer

(2013) C. Parker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Histone Demethylases Set the Stage for Cancer Metastasis

(2013) J. Cao et al.   Science Signaling

EMT and Dissemination Precede Pancreatic Tumor Formation

(2012) Andrew D. Rhim et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Surgical Management of Hepatic Neuroendocrine Tumor Metastasis: Results from an International Multi-Institutional Analysis

(2010) Skye C. Mayo et al.   ANNALS OF SURGICAL ONCOLOGY

AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective

(2010) J. E. Talmadge et al.   CANCER RESEARCH

Survival after Hepatic Resection for Metastatic Colorectal Cancer: Trends in Outcomes for 1,600 Patients during Two Decades at a Single Institution

(2010) Michael G. House et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Tumor Self-Seeding by Circulating Cancer Cells

(2009) Mi-Young Kim et al.   CELL

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Systemic Spread Is an Early Step in Breast Cancer

(2008) Yves Hüsemann et al.   CANCER CELL

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Seeding and Propagation of Untransformed Mouse Mammary Cells in the Lung

(2008) K. Podsypanina et al.   SCIENCE