Insights and opportunities at the crossroads of cancer and neuroscience

Olfactory sensory experience regulates gliomagenesis via neuronal IGF1

(2022) Pengxiang Chen et al.   NATURE

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma

(2021) Erik Jung et al.   Nature Communications

Meclofenamate causes loss of cellular tethering and decoupling of functional networks in glioblastoma

(2021) Matthias Schneider et al.   NEURO-ONCOLOGY

NF1 mutation drives neuronal activity-dependent initiation of optic glioma

(2021) Yuan Pan et al.   NATURE

Loss of p53 drives neuron reprogramming in head and neck cancer

(2020) Moran Amit et al.   NATURE

PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis

(2020) Kwanha Yu et al.   NATURE

Tissue clearing and its applications in neuroscience

(2020) Hiroki R. Ueda et al.   NATURE REVIEWS NEUROSCIENCE

Roadmap for the Emerging Field of Cancer Neuroscience

(2020) Michelle Monje et al.   CELL

CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients

(2020) Michael Hirth et al.   GASTROENTEROLOGY

Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner

(2020) Casey J. Latario et al.   MOLECULAR BIOLOGY OF THE CELL

Clinically Actionable Strategies for Studying Neural Influences in Cancer

(2020) Ihsan Ekin Demir et al.   CANCER CELL

Cell Types Promoting Goosebumps Form a Niche to Regulate Hair Follicle Stem Cells

(2020) Yulia Shwartz et al.   CELL

Beta-Blockers and Cancer: Where Are We?

(2020) Rita Peixoto et al.   Pharmaceuticals

Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential

(2020) Siyi Huang et al.   CELL

Nociceptive nerves regulate haematopoietic stem cell mobilization

(2020) Xin Gao et al.   NATURE

Progenitors from the central nervous system drive neurogenesis in cancer

(2019) Philippe Mauffrey et al.   NATURE

Tumor Neurobiology and the War of Nerves in Cancer

(2019) Sam Faulkner et al.   Cancer Discovery

Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression

(2019) Atsunori Kamiya et al.   NATURE NEUROSCIENCE

Electrical and synaptic integration of glioma into neural circuits

(2019) Humsa S. Venkatesh et al.   NATURE

Glutamatergic synaptic input to glioma cells drives brain tumour progression

(2019) Varun Venkataramani et al.   NATURE

Synaptic proximity enables NMDAR signalling to promote brain metastasis

(2019) Qiqun Zeng et al.   NATURE

β2 adrenergic receptor–mediated signaling regulates the immunosuppressive potential of myeloid-derived suppressor cells

(2019) Hemn Mohammadpour et al.   JOURNAL OF CLINICAL INVESTIGATION

Emerging intersections between neuroscience and glioma biology

(2019) Erik Jung et al.   NATURE NEUROSCIENCE

Deep Learning Reveals Cancer Metastasis and Therapeutic Antibody Targeting in the Entire Body

(2019) Chenchen Pan et al.   CELL

An intravital window to image the colon in real time

(2019) Nikolai Rakhilin et al.   Nature Communications

GKAP Acts as a Genetic Modulator of NMDAR Signaling to Govern Invasive Tumor Growth

(2018) Leanne Li et al.   CANCER CELL

β2 Adrenergic-Neurotrophin Feedforward Loop Promotes Pancreatic Cancer

(2018) Bernhard W. Renz et al.   CANCER CELL

Harmful networks in the brain and beyond

(2018) Frank Winkler et al.   SCIENCE

Panoptic imaging of transparent mice reveals whole-body neuronal projections and skull–meninges connections

(2018) Ruiyao Cai et al.   NATURE NEUROSCIENCE

Tweety-Homolog 1 Drives Brain Colonization of Gliomas

(2017) Erik Jung et al.   JOURNAL OF NEUROSCIENCE

Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma

(2017) Humsa S. Venkatesh et al.   NATURE

A permanent window for the murine lung enables high-resolution imaging of cancer metastasis

(2017) David Entenberg et al.   NATURE METHODS

Tumor microtubes convey resistance to surgical lesions and chemotherapy in gliomas

(2017) Sophie Weil et al.   NEURO-ONCOLOGY

Influence of the neural microenvironment on prostate cancer

(2017) Christian Coarfa et al.   PROSTATE

Adrenergic nerves activate an angio-metabolic switch in prostate cancer

(2017) Ali H. Zahalka et al.   SCIENCE

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

(2017) Yifeng Lei et al.   Nature Communications

Whole-Body Profiling of Cancer Metastasis with Single-Cell Resolution

(2017) Shimpei I. Kubota et al.   Cell Reports

Schwann cells induce cancer cell dispersion and invasion

(2016) Sylvie Deborde et al.   JOURNAL OF CLINICAL INVESTIGATION

Seizures and gliomas — towards a single therapeutic approach

(2016) Gilles Huberfeld et al.   Nature Reviews Neurology

Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer

(2016) Jami L. Saloman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

(2016) Zina Dubeykovskaya et al.   Nature Communications

A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain

(2015) Deepitha Selvaraj et al.   CANCER CELL

Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion

(2015) Humsa S. Venkatesh et al.   CELL

Basal Cell Carcinoma Preferentially Arises from Stem Cells within Hair Follicle and Mechanosensory Niches

(2015) Shelby C. Peterson et al.   Cell Stem Cell

Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer

(2015) Jay Pundavela et al.   Molecular Oncology

Brain tumour cells interconnect to a functional and resistant network

(2015) Matthias Osswald et al.   NATURE

ProNGF Correlates with Gleason Score and Is a Potential Driver of Nerve Infiltration in Prostate Cancer

(2014) Jay Pundavela et al.   AMERICAN JOURNAL OF PATHOLOGY

Neuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma

(2014) Rachelle E. Stopczynski et al.   CANCER RESEARCH

Granulocyte colony-stimulating factor off-target effect on nerve outgrowth promotes prostate cancer development

(2014) Kostantin Dobrenis et al.   INTERNATIONAL JOURNAL OF CANCER

GFR 1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling

(2014) S. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Denervation suppresses gastric tumorigenesis

(2014) C.-M. Zhao et al.   Science Translational Medicine

Hijacking the Neuronal NMDAR Signaling Circuit to Promote Tumor Growth and Invasion

(2013) Leanne Li et al.   CELL

Autonomic Nerve Development Contributes to Prostate Cancer Progression

(2013) C. Magnon et al.   SCIENCE

Endoneurial Macrophages Induce Perineural Invasion of Pancreatic Cancer Cells by Secretion of GDNF and Activation of RET Tyrosine Kinase Receptor

(2012) O. Cavel et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL