Review
Biochemistry & Molecular Biology
Bo Dong, Yadi Wu
Summary: SNAI1, a zinc finger transcription factor, plays a crucial role in cancer metastasis by regulating transcriptional, translational, and post-translational levels. Epigenetic regulation and post-translational modifications are key mechanisms for the regulation of SNAI1 in cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
David P. Cook, Barbara C. Vanderhyden
Summary: Epithelial-mesenchymal plasticity (EMP) is closely related to tumor progression, therapy resistance and immune cell evasion. By analyzing single-cell RNA sequencing data, we found diverse EMP expression patterns within tumors, which are regulated by various mechanisms initiated from the tumor microenvironment. Inferring regulatory features can provide effective therapeutic strategies to restrict EMP.
Article
Oncology
Masao Saitoh
Summary: The epithelial-mesenchymal transition (EMT) is a process where epithelial cells transform into mesenchymal cells, which is associated with invasion, metastasis, and resistance to therapy in cancer. Transcription factors, such as ZEB1/ZEB2, SNAIL, and TWIST, play important roles in driving the EMT process. This review focuses on understanding the molecular mechanisms that sustain high levels of these transcription factors in aggressive carcinomas and their upregulation by transforming growth factor-β during cancer progression.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Cell Biology
Nicolas Curdy, Olivia Lanvin, Sarah Cadot, Camille Laurent, Jean-Jacques Fournie, Don-Marc Franchini
Summary: Immune cell activation leads to transcriptional and translational programs, with stress granules playing a crucial role in controlling protein synthesis and ensuring accurate effector functions in immune cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Tuan Luu
Summary: Pancreatic cancer, known for its high mortality and insensitivity to existing therapies, has attracted increasing scholarly attention for its progression mechanisms, particularly the role of epithelial-mesenchymal transition (EMT) in cancer genesis and metastasis. Recent discoveries on EMT-regulating factors in pancreatic cancer have shed light on the relationship between EMT and this cancer type, marking a key advancement in research on EMT in pancreatic cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Ewa Nowak, Ilona Bednarek
Summary: Epithelial to mesenchymal transition (EMT) is a critical process in tumor progression that influences metastasis, characterized by loss of cell adhesion and polarity, and enhanced cell motility. Epigenetic regulatory mechanisms play a significant role in the gene expression involved in EMT, impacting the development and progression of cancer.
Review
Biochemical Research Methods
Mattia Furlan, Stefano de Pretis, Mattia Pelizzola
Summary: Despite RNA abundance being commonly assumed as a proxy for transcriptional activity, it is now possible to calculate how synthesis, processing, and degradation rates collectively determine the abundance of each gene's RNA. Different transcriptional outputs can correspond to different combinations of kinetic rates, indicating the existence of markedly different modes of gene expression regulation and their profound effects on gene self-expression regulation.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Oncology
Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao
Summary: PRMT5 and LSD1 form a complex with Slug and promote breast cancer invasion. They inhibit E-cadherin expression and activate vimentin expression through dual transcriptional activities. Both PRMT5 and LSD1 are coordinately expressed in breast cancer patients and simultaneous inhibition of both proteins shows a synergetic effect in inhibiting breast tumor growth and metastasis.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Chun-Ying Luo, Wei-Chao Su, Hai-Feng Jiang, Ling-Tao Luo, Dong-Yan Shen, Guo-Qiang Su
Summary: This study reveals the important role of DPY30 in CRC progression and metastasis. DPY30 promotes EMT and CRC metastasis by upregulating the transcriptional expression of ZEB1. Therefore, DPY30 may serve as a therapeutic target and prognostic marker for CRC.
CANCER CELL INTERNATIONAL
(2023)
Article
Reproductive Biology
Wei-Peng He, Gui-Ping Yang, Zun-Xian Yang, Hong-Wei Shen, Ze-Shan You, Guo-Fen Yang
Summary: This study found that overexpression of MAEL in epithelial ovarian cancer is associated with tumor malignancy, staging, and patient survival. MAEL promotes invasiveness/metastasis and induces EMT in EOC by upregulating FGFR4. Therefore, MAEL may serve as a potential therapeutic target for EOC.
JOURNAL OF OVARIAN RESEARCH
(2022)
Article
Oncology
Jie Zhou, Lvying Wu, Pengyan Xu, Yue Li, Zhiliang Ji, Xinmei Kang
Summary: This study identified potential driver genes of breast cancer metastasis through whole-exome sequencing and demonstrated FLNA as a potential driver gene for metastasis. Knocking out FLNA inhibited the metastatic abilities of tumor cells. The findings provide new insights into breast cancer metastasis and suggest a potential therapeutic target for breast cancer therapy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Cell Biology
Qiuqin Ma, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, Ling Tian
Summary: Autophagy, a widely conserved process in eukaryotes, is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. It is primarily governed at the RNA and protein levels in a synergistic manner.
Article
Oncology
Rohan R. Katipally, Sean P. Pitroda, Ralph R. Weichselbaum, Samuel Hellman
Summary: The oligometastasis hypothesis suggests that metastases exist on a spectrum and are not always disseminated. Identifying patients most likely to have an oligometastatic phenotype is difficult. Recent research on epigenetic regulators of epithelial-mesenchymal transition (EMT) has shed light on the emergence of a spectrum of metastatic behavior.
CLINICAL CANCER RESEARCH
(2023)
Review
Chemistry, Medicinal
Hui Li Ang, Chakrabhavi Dhananjaya Mohan, Muthu K. Shanmugam, Hin Chong Leong, Pooyan Makvandi, Kanchugarakoppal S. Rangappa, Anupam Bishyaee, Alan Prem Kumar, Gautam Sethi
Summary: Epithelial-mesenchymal transition (EMT) is a crucial process in which epithelial cells transform into mesenchymal cells, playing a significant role in tumor progression and resistance to therapy. Various factors, such as signaling pathways, transcriptional regulators, noncoding RNAs, and epigenetic alterations, are involved in the regulation of EMT. However, despite preclinical data, there is a lack of clinical translation in targeting EMT therapeutically. This review discusses the role of these factors in EMT regulation, the contribution of EMT to drug resistance, and potential therapeutic interventions using natural products and nano-formulations as EMT blockers.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Oncology
Hersh Ham-Karim, Ola Negm, Narmeen Ahmad, Mohammad Ilyas
Summary: There are molecular discrepancies between primary colorectal cancer and their respective metastases, including genetic mutations, miRNA expression, and protein biomarker alterations.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Hongbing Chen, Tianjie Yang, Zhe Lei, Longqiang Wang, Haiping Yang, Xin Tong, Wen-Tao Yang, Jun Zhao, Yunbin Gu, Yongbing Chen, Hong-Tao Zhang
Article
Oncology
Haiping Yang, Longqiang Wang, Jun Zhao, Yongbing Chen, Zhe Lei, Xia Liu, Wei Xia, Lingling Guo, Hong-Tao Zhang
Article
Biochemistry & Molecular Biology
L. Wang, H. Yang, Z. Lei, J. Zhao, Y. Chen, P. Chen, C. Li, Y. Zeng, Z. Liu, X. Liu, H-T Zhang
Article
Oncology
Haiping Yang, Lei Zhan, Tianjie Yang, Longqiang Wang, Chang Li, Jun Zhao, Zhe Lei, Xiangdong Li, Hong-Tao Zhang
Article
Oncology
Haiping Huang, Peng Sun, Zhe Lei, Manyi Li, Yihong Wang, Hong-Tao Zhang, Jisheng Liu
Article
Oncology
Haibo Hu, Zhenlei Xu, Chang Li, Chun Xu, Zhe Lei, Hong-Tao Zhang, Jun Zhao
Article
Oncology
Qinghui Yang, Liang Wan, Can Xiao, Haibo Hu, Longqiang Wang, Jun Zhao, Zhe Lei, Hong-Tao Zhang
Article
Oncology
Chang Li, Liang Wan, Zeyi Liu, Guangquan Xu, Shengjie Wang, Zhiyue Su, Yingxi Zhang, Cuijuan Zhang, Xia Liu, Zhe Lei, Hong-Tao Zhang
Article
Biochemistry & Molecular Biology
Longqiang Wang, Xin Tong, Zhengyu Zhou, Shengjie Wang, Zhe Lei, Tianze Zhang, Zeyi Liu, Yuanyuan Zeng, Chang Li, Jun Zhao, Zhiyue Su, Cuijuan Zhang, Xia Liu, Guangquan Xu, Hong-Tao Zhang
Article
Biochemistry & Molecular Biology
Xin Tong, Shengjie Wang, Zhe Lei, Chang Li, Cuijuan Zhang, Zhiyue Su, Xia Liu, Jun Zhao, Hong-Tao Zhang
Article
Biochemistry & Molecular Biology
Shengjie Wang, Xin Tong, Chang Li, Ersuo Jin, Zhiyue Su, Zelong Sun, Weiwei Zhang, Zhe Lei, Hong-Tao Zhang
Summary: QKI-5 is significantly decreased in metastatic lung adenocarcinoma, and its overexpression inhibits TGF-beta-induced EMT and invasion. KLF6 positively regulates QKI-5 at the transcriptional level, which is associated with TGF beta R1. Targeting the KLF6/QKI-5/TGF beta R1 axis may be a promising strategy for treating LUAD.
Article
Biochemistry & Molecular Biology
Zelong Sun, Zhiyue Su, Zhengyu Zhou, Shengjie Wang, Zhao Wang, Xin Tong, Chang Li, Yuxin Wang, Xiaoyan Chen, Zhe Lei, Hong-Tao Zhang
Summary: ALKBH5 plays a key role in regulating TGF-beta/SMAD signaling and controlling TGF-beta-induced EMT in NSCLCs. ALKBH5 expression is significantly reduced in metastatic NSCLC and its overexpression inhibits TGF-beta-induced EMT and invasion of NSCLC cells. ALKBH5 affects the expression and mRNA stability of TGF beta R2, SMAD3, and SMAD6 by erasing m(6)A modification in NSCLC cells, and interacts with m(6)A-binding proteins to further regulate TGF-beta signaling.
Article
Cell Biology
Zhiyue Su, Zelong Sun, Zhao Wang, Shengjie Wang, Yuxin Wang, Ersuo Jin, Chang Li, Jun Zhao, Zeyi Liu, Zhengyu Zhou, Yong Wang, Xiaoyan Chen, Xia Liu, Zhe Lei, Hong-Tao Zhang
Summary: This study reveals the molecular mechanisms underlying lung adenocarcinoma (LUAD) metastasis, highlighting the crucial role of the TAF15/TBP complex in promoting EMT and invasion of LUAD cells, which is inhibited by TIF1y.
Article
Medicine, Research & Experimental
Junyi Gu, Zhongsheng Lu, Chenghong Ji, Yuchao Chen, Yuzhao Liu, Zhe Lei, Longqiang Wang, Hong-Tao Zhang, Xiangdong Li
BIOMEDICINE & PHARMACOTHERAPY
(2017)