Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells

Coenzyme Q0 Inhibits NLRP3 Inflammasome Activation through Mitophagy Induction in LPS/ATP-Stimulated Macrophages

(2022) You-Cheng Hseu et al.   Oxidative Medicine and Cellular Longevity

HUNK Regulation of Interleukin 4 in Triple Negative Breast Cancer

(2022) Nicole Ramos Solis et al.   FASEB JOURNAL

Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment

(2022) Shilin Wang et al.   Frontiers in Immunology

Regulation and Function of Matrix Metalloproteinase-13 in Cancer Progression and Metastasis

(2022) Shun Li et al.   Cancers

A pyroptosis-associated signature plays a role in prognosis prediction in clear cell renal cell carcinoma

(2022) Zhiyuan Li et al.   BMC Medical Genomics

The Warburg effect in osteoporosis: Cellular signaling and epigenetic regulation of energy metabolic events to targeting the osteocalcin for phenotypic alteration

(2022) Chithravel Vadivalagan et al.   CELLULAR SIGNALLING

Coenzyme Q0, a novel quinone derivative of Antrodia camphorata, induces ROS-mediated cytotoxic autophagy and apoptosis against human glioblastoma cells in vitro and in vivo

(2021) Hsin-Ling Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Phytocompounds Targeting Metabolic Reprogramming in Cancer: An Assessment of Role, Mechanisms, Pathways, and Therapeutic Relevance

(2021) Asifa Khan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Pyruvate Kinase M2 and Cancer: The Role of PKM2 in Promoting Tumorigenesis

(2020) Kulsoom Zahra et al.   Frontiers in Oncology

Silibinin induces metabolic crisis in triple‐negative breast cancer cells by modulating EGFR‐MYC‐TXNIP axis: potential therapeutic implications

(2020) Mohammad Askandar Iqbal et al.   FEBS Journal

Metabolic Reprogramming in Triple-Negative Breast Cancer

(2020) Xiangyu Sun et al.   Frontiers in Oncology

NLRP3 Inflammasome Activation in Cancer: A Double-Edged Sword

(2020) Shaima'a Hamarsheh et al.   Frontiers in Immunology

HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance

(2019) Ayako Nagao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Occurrence of the potent mutagens 2- nitrobenzanthrone and 3-nitrobenzanthrone in fine airborne particles

(2019) Aldenor G. Santos et al.   Scientific Reports

Metabolic regulation of inflammasomes in inflammation

(2019) Qiuli Yang et al.   IMMUNOLOGY

Defining the Hallmarks of Metastasis

(2019) Danny R. Welch et al.   CANCER RESEARCH

Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis

(2019) Hsin-Ling Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming

(2019) Jinmei Jin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Pharmacological Inhibitors of the NLRP3 Inflammasome

(2019) Ayesha Zahid et al.   Frontiers in Immunology

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

(2018) Alena Grebe et al.   CIRCULATION RESEARCH

Curcumin decreases Warburg effect in cancer cells by down-regulating pyruvate kinase M2 via mTOR-HIF1α inhibition

(2018) Farid Ahmad Siddiqui et al.   Scientific Reports

N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

(2018) Krzysztof Marek Mrozik et al.   BMC CANCER

Metabolic regulation of NLRP3

(2017) Mark M. Hughes et al.   IMMUNOLOGICAL REVIEWS

Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells

(2017) You-Cheng Hseu et al.   JOURNAL OF ETHNOPHARMACOLOGY

HIF-1α induces the epithelial-mesenchymal transition in gastric cancer stem cells through the Snail pathway

(2017) Shi-wei Yang et al.   Oncotarget

Coenzyme Q0 Enhances Ultraviolet B–Induced Apoptosis in Human Estrogen Receptor–Positive Breast (MCF-7) Cancer Cells

(2016) Hui-Min Wang et al.   INTEGRATIVE CANCER THERAPIES

Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles

(2016) Qian Sun et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CD44 high CD24 low molecular signature determines the Cancer Stem Cell and EMT phenotype in Oral Squamous Cell Carcinoma

(2016) Sangeeta Ghuwalewala et al.   Stem Cell Research

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

In vitro and in vivo anti-tumor activity of CoQ0 against melanoma cells: inhibition of metastasis and induction of cell-cycle arrest and apoptosis through modulation of Wnt/β-catenin signaling pathways

(2016) You-Cheng Hseu et al.   Oncotarget

Aldehyde dehydrogenase 1A1 in stem cells and cancer

(2016) Hiroyuki Tomita et al.   Oncotarget

Anti-angiogenic properties of coenzyme Q0 through downregulation of MMP-9/NF-κB and upregulation of HO-1 signaling in TNF-α-activated human endothelial cells

(2015) Hsin-Ling Yang et al.   BIOCHEMICAL PHARMACOLOGY

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

Metabolic reprogramming: the emerging concept and associated therapeutic strategies

(2015) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Cancer metabolism and the Warburg effect: the role of HIF-1 and PI3K

(2015) Rupert Courtnay et al.   MOLECULAR BIOLOGY REPORTS

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

(2015) Bradley A. Webb et al.   NATURE

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Restoration of E-cadherin Cell-Cell Junctions Requires Both Expression of E-cadherin and Suppression of ERK MAP Kinase Activation in Ras-Transformed Breast Epithelial Cells

(2015) Quanwen Li et al.   NEOPLASIA

Mortality of breast cancer in Taiwan, 1971–2010: Temporal changes and an age–period–cohort analysis

(2014) M.-L. Ho et al.   JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition

(2013) Elias H. Barriga et al.   JOURNAL OF CELL BIOLOGY

Pyruvate Dehydrogenase Kinases in the Nervous System: Their Principal Functions in Neuronal-glial Metabolic Interaction and Neuro-metabolic Disorders

(2012) Mithilesh Kumar Jha et al.   Current Neuropharmacology

Hypoxia induces CXCR4 expression and biological activity in gastric cancer cells through activation of hypoxia-inducible factor-1α

(2012) YOON SUK OH et al.   ONCOLOGY REPORTS

Molecular mechanisms of inflammasome activation during microbial infections

(2011) Petr Broz et al.   IMMUNOLOGICAL REVIEWS

Antrodia camphorata suppresses lipopolysaccharide-induced nuclear factor-κB activation in transgenic mice evaluated by bioluminescence imaging

(2010) You-Cheng Hseu et al.   FOOD AND CHEMICAL TOXICOLOGY

Anti-metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway

(2010) Hsin-Ling Yang et al.   FOOD AND CHEMICAL TOXICOLOGY

Hypoxia-induced metabolic shifts in cancer cells: Moving beyond the Warburg effect

(2010) Aalim M. Weljie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Epithelial–mesenchymal transition in the skin

(2010) Motonobu Nakamura et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Review of Pharmacological Effects ofAntrodia camphorataand Its Bioactive Compounds

(2009) Madamanchi Geethangili et al.   Evidence-based Complementary and Alternative Medicine

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

A role for phosphatidic acid in COPI vesicle fission yields insights into Golgi maintenance

(2008) Jia-Shu Yang et al.   NATURE CELL BIOLOGY

Direct regulation of TWIST by HIF-1α promotes metastasis

(2008) Muh-Hwa Yang et al.   NATURE CELL BIOLOGY