Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment
Authors
Keywords
-
Journal
Frontiers in Immunology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-07-07
DOI
10.3389/fimmu.2022.840029
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Sapanisertib plus Fulvestrant in Postmenopausal Women with Estrogen Receptor–Positive/HER2-Negative Advanced Breast Cancer after Progression on Aromatase Inhibitor
- (2022) José Á. García-Sáenz et al. CLINICAL CANCER RESEARCH
- The CTCF/LncRNA‐PACERR complex recruits E1A binding protein p300 to induce pro‐tumour macrophages in pancreatic ductal adenocarcinoma via directly regulating PTGS2 expression
- (2022) Yihao Liu et al. Clinical and Translational Medicine
- Glutamine, MTOR and autophagy: a multiconnection relationship
- (2022) Clément Bodineau et al. Autophagy
- PERK is a critical metabolic hub for immunosuppressive function in macrophages
- (2022) Lydia N. Raines et al. NATURE IMMUNOLOGY
- Notch-mediated lactate metabolism regulates MDSC development through the Hes1/MCT2/c-Jun axis
- (2022) Jun-Long Zhao et al. Cell Reports
- Metabolic Reprogramming Induces Immune Cell Dysfunction in the Tumor Microenvironment of Multiple Myeloma
- (2021) Shaojie Wu et al. Frontiers in Oncology
- Research trends in pharmacological modulation of tumor‐associated macrophages
- (2021) Neng Wang et al. Clinical and Translational Medicine
- Epigenetic silencing of miR-144/451a cluster contributes to HCC progression via paracrine HGF/MIF-mediated TAM remodeling
- (2021) Junlong Zhao et al. Molecular Cancer
- Metabolic support of tumour-infiltrating regulatory T cells by lactic acid
- (2021) McLane J. Watson et al. NATURE
- A phase I trial of the mTOR inhibitor temsirolimus in combination with capecitabine in patients with advanced malignancies
- (2021) Neel D. Trivedi et al. Cancer Medicine
- Tumor-associated neutrophils and macrophages interaction contributes to intrahepatic cholangiocarcinoma progression by activating STAT3
- (2021) Zhengjun Zhou et al. Journal for ImmunoTherapy of Cancer
- Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines
- (2021) Jonas Parczyk et al. BMC CANCER
- Metabolic reprogramming due to hypoxia in pancreatic cancer: Implications for tumor formation, immunity, and more
- (2021) Xiaodong Hao et al. BIOMEDICINE & PHARMACOTHERAPY
- Dual Covalent Inhibition of PKM and IMPDH Targets Metabolism in Cutaneous Metastatic Melanoma
- (2021) Marwa Zerhouni et al. CANCER RESEARCH
- Targeting Glucose Metabolism Sensitizes Pancreatic Cancer to MEK Inhibition
- (2021) Liang Yan et al. CANCER RESEARCH
- Can tumor cells take it all away?
- (2021) Anna Kohl et al. Cell Metabolism
- A pilot study of everolimus and radiation for neuroendocrine liver metastases
- (2021) Sten Myrehaug et al. ENDOCRINE-RELATED CANCER
- Macrophage Polarization States in the Tumor Microenvironment
- (2021) Ava J. Boutilier et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer
- (2021) Yanjuan Huang et al. Nature Communications
- USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade
- (2021) Zhaojuan Yang et al. Nature Communications
- MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages
- (2021) Seyeon Bae et al. Cell Reports
- Arachidonic Acid Metabolism Controls Macrophage Alternative Activation Through Regulating Oxidative Phosphorylation in PPARγ Dependent Manner
- (2021) Miao Xu et al. Frontiers in Immunology
- Effectiveness of Adding Everolimus to the First-line Treatment of Advanced Breast Cancer in Premenopausal Women Who Experienced Disease Progression While Receiving Selective Estrogen Receptor Modulators
- (2021) Ying Fan et al. JAMA Oncology
- PI3Kα inhibitor CYH33 triggers antitumor immunity in murine breast cancer by activating CD8+T cells and promoting fatty acid metabolism
- (2021) Pu Sun et al. Journal for ImmunoTherapy of Cancer
- An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor
- (2021) Yukari Shirai et al. Cancers
- The impact of non-coding RNAs on macrophage polarization
- (2021) Soudeh Ghafouri-Fard et al. BIOMEDICINE & PHARMACOTHERAPY
- Recent advancement on development of drug-induced macrophage polarization in control of human diseases
- (2021) Lu Wang et al. LIFE SCIENCES
- Belzutifan for Renal Cell Carcinoma in von Hippel–Lindau Disease
- (2021) Eric Jonasch et al. NEW ENGLAND JOURNAL OF MEDICINE
- Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization
- (2021) Mei-Mei Wu et al. PHARMACOLOGICAL RESEARCH
- Parsing the Role of PPARs in Macrophage Processes
- (2021) Daniel Toobian et al. Frontiers in Immunology
- Alternatively activated macrophages; a double-edged sword in allergic asthma
- (2020) Mohamed Hamed Abdelaziz et al. Journal of Translational Medicine
- Regulation of Adipocyte and Macrophage Functions by mTORC1 and 2 in Metabolic Diseases
- (2020) William T. Festuccia MOLECULAR NUTRITION & FOOD RESEARCH
- Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase
- (2020) Erika M. Palmieri et al. Nature Communications
- New Insights on the Role of Lipid Metabolism in the Metabolic Reprogramming of Macrophages
- (2020) Ana Batista-Gonzalez et al. Frontiers in Immunology
- MK-2206 and Standard Neoadjuvant Chemotherapy Improves Response in Patients With Human Epidermal Growth Factor Receptor 2–Positive and/or Hormone Receptor–Negative Breast Cancers in the I-SPY 2 Trial
- (2020) A. Jo Chien et al. JOURNAL OF CLINICAL ONCOLOGY
- Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer
- (2020) Sophie J. Cowman et al. CLINICAL CANCER RESEARCH
- Akt Inhibition Is Associated With Favorable Immune Profile Changes Within the Tumor Microenvironment of Hormone Receptor Positive, HER2 Negative Breast Cancer
- (2020) Douglas K. Marks et al. Frontiers in Oncology
- Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer
- (2020) Martin H. Voss et al. BRITISH JOURNAL OF CANCER
- The Role of HIF in Immunity and Inflammation
- (2020) Anne F. McGettrick et al. Cell Metabolism
- Targeting hypoxia-inducible factor-1, for cancer treatment: Recent advances in developing small-molecule inhibitors from natural compounds
- (2020) Zhaowu Ma et al. SEMINARS IN CANCER BIOLOGY
- Hyperglycemia Enhances Cancer Immune Evasion by Inducing Alternative Macrophage Polarization through Increased O-GlcNAcylation
- (2020) Natália Rodrigues Mantuano et al. Cancer Immunology Research
- Metabolic reprograming of tumor-associated macrophages
- (2020) Abhishek Puthenveetil et al. Annals of Translational Medicine
- Targeted systemic dendrimer delivery of CSF‐1R inhibitor to tumor‐associated macrophages improves outcomes in orthotopic glioblastoma
- (2020) Kevin Liaw et al. Bioengineering & Translational Medicine
- Navigating metabolic pathways to enhance antitumour immunity and immunotherapy
- (2019) Xiaoyun Li et al. Nature Reviews Clinical Oncology
- Extracellular vesicle-packaged HIF-1α-stabilizing lncRNA from tumour-associated macrophages regulates aerobic glycolysis of breast cancer cells
- (2019) Fei Chen et al. NATURE CELL BIOLOGY
- Randomized Phase II Trial of Bevacizumab or Temsirolimus in Combination With Chemotherapy for First Relapse Rhabdomyosarcoma: A Report From the Children’s Oncology Group
- (2019) Leo Mascarenhas et al. JOURNAL OF CLINICAL ONCOLOGY
- HIF-1α as a central mediator of cellular resistance to intracellular pathogens
- (2019) Matthew Knight et al. CURRENT OPINION IN IMMUNOLOGY
- Everolimus Plus Exemestane vs Everolimus or Capecitabine Monotherapy for Estrogen Receptor–Positive, HER2-Negative Advanced Breast Cancer
- (2018) Guy Jerusalem et al. JAMA Oncology
- Astragaloside IV inhibits lung cancer progression and metastasis by modulating macrophage polarization through AMPK signaling
- (2018) Fei Xu et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Shikonin Inhibits Tumor Growth in Mice by Suppressing Pyruvate Kinase M2-mediated Aerobic Glycolysis
- (2018) Xiaoyue Zhao et al. Scientific Reports
- The role of the hypoxia-Nrp-1 axis in the activation of M2-like tumor-associated macrophages in the tumor microenvironment of cervical cancer
- (2018) Xiao-Jing Chen et al. MOLECULAR CARCINOGENESIS
- mTORC1 and mTORC2 as regulators of cell metabolism in immunity
- (2017) Monika Linke et al. FEBS LETTERS
- The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases
- (2017) Hajime Abe et al. Journal of Atherosclerosis and Thrombosis
- HIF1α-Induced Glycolysis Metabolism Is Essential to the Activation of Inflammatory Macrophages
- (2017) Ting Wang et al. MEDIATORS OF INFLAMMATION
- Targeting tumor associated macrophages: The new challenge for nanomedicine
- (2017) Fernando Torres Andón et al. SEMINARS IN IMMUNOLOGY
- Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages
- (2017) Hirokazu Nakatsumi et al. Cell Reports
- 2-Deoxy-d-Glucose Treatment Decreases Anti-inflammatory M2 Macrophage Polarization in Mice with Tumor and Allergic Airway Inflammation
- (2017) Qingjie Zhao et al. Frontiers in Immunology
- Renalase Expression by Melanoma and Tumor-Associated Macrophages Promotes Tumor Growth through a STAT3-Mediated Mechanism
- (2016) Lindsay Hollander et al. CANCER RESEARCH
- Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis
- (2016) Mathias Wenes et al. Cell Metabolism
- Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity
- (2016) Rob J.W. Arts et al. Cell Metabolism
- Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation
- (2016) Stanley Ching-Cheng Huang et al. IMMUNITY
- Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment
- (2016) Di Liu et al. JOURNAL OF PROTEOME RESEARCH
- IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma
- (2016) Salah-Eddine Lamhamedi-Cherradi et al. JNCI-Journal of the National Cancer Institute
- Fatty acid oxidation in macrophage polarization
- (2016) Mitsunori Nomura et al. NATURE IMMUNOLOGY
- A phase I study of perifosine with temsirolimus for recurrent pediatric solid tumors
- (2016) Oren J. Becher et al. PEDIATRIC BLOOD & CANCER
- Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages
- (2016) Jan Van den Bossche et al. Cell Reports
- Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
- (2016) Anthony J Covarrubias et al. eLife
- IGF-1R and mTOR Blockade: Novel Resistance Mechanisms and Synergistic Drug Combinations for Ewing Sarcoma
- (2016) Salah-Eddine Lamhamedi-Cherradi et al. JNCI-Journal of the National Cancer Institute
- Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages
- (2016) Rob J. W. Arts et al. OncoImmunology
- Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma
- (2016) Hweixian Leong Penny et al. OncoImmunology
- Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation
- (2015) Maria Ida Malandrino et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
- (2015) R. Hughes et al. CANCER RESEARCH
- Metabolic reprogramming in macrophages and dendritic cells in innate immunity
- (2015) Beth Kelly et al. CELL RESEARCH
- Targeting angiogenesis in endometrial cancer - new agents for tailored treatments
- (2015) Anselmo Papa et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Overexpression of pyruvate dehydrogenase kinase supports dichloroacetate as a candidate for cutaneous melanoma therapy
- (2015) Helena Pópulo et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis
- (2015) Jong-Seok Moon et al. JOURNAL OF CLINICAL INVESTIGATION
- T cell exclusion, immune privilege, and the tumor microenvironment
- (2015) J. A. Joyce et al. SCIENCE
- Regulation of mTORC1 by PI3K signaling
- (2015) Christian C. Dibble et al. TRENDS IN CELL BIOLOGY
- Loss of PTEN Promotes Resistance to T Cell-Mediated Immunotherapy
- (2015) W. Peng et al. Cancer Discovery
- M-CSF from Cancer Cells Induces Fatty Acid Synthase and PPARβ/δ Activation in Tumor Myeloid Cells, Leading to Tumor Progression
- (2015) Jonghanne Park et al. Cell Reports
- Much More than M1 and M2 Macrophages, There are also CD169+ and TCR+ Macrophages
- (2015) Leslie Chávez-Galán et al. Frontiers in Immunology
- Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
- (2014) Peter J. Murray et al. IMMUNITY
- Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer
- (2014) Edward B. Garon et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Adenosine 5'-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype
- (2014) D. Sag et al. JOURNAL OF IMMUNOLOGY
- Adenosine 5′-Monophosphate–Activated Protein Kinase Regulates IL-10–Mediated Anti-Inflammatory Signaling Pathways in Macrophages
- (2014) Yanfang Peipei Zhu et al. JOURNAL OF IMMUNOLOGY
- Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
- (2014) Oscar R. Colegio et al. NATURE
- Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages
- (2014) Stanley Ching-Cheng Huang et al. NATURE IMMUNOLOGY
- mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity
- (2014) S.-C. Cheng et al. SCIENCE
- TSC1 controls macrophage polarization to prevent inflammatory disease
- (2014) Linnan Zhu et al. Nature Communications
- Regulation and function of pyruvate kinase M2 in cancer
- (2013) Weiwei Yang et al. CANCER LETTERS
- Akt1-Mediated Regulation of Macrophage Polarization in a Murine Model of Staphylococcus aureus Pulmonary Infection
- (2013) Feng Xu et al. JOURNAL OF INFECTIOUS DISEASES
- Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
- (2013) Stephen Yiu Chuen Choi et al. JOURNAL OF PATHOLOGY
- Metabolism of inflammation limited by AMPK and pseudo-starvation
- (2013) Luke A. J. O'Neill et al. NATURE
- Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphoma
- (2012) A Naing et al. BRITISH JOURNAL OF CANCER
- A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors
- (2012) Luis E. Raez et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Receptor Tyrosine Kinases and TLR/IL1Rs Unexpectedly Activate Myeloid Cell PI3Kγ, A Single Convergent Point Promoting Tumor Inflammation and Progression
- (2011) Michael C. Schmid et al. CANCER CELL
- Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
- (2011) Kristina Goetze INTERNATIONAL JOURNAL OF ONCOLOGY
- The phosphatidyl inositol 3-kinase/AKT signaling pathway in breast cancer
- (2010) Carlos A. Castaneda et al. CANCER AND METASTASIS REVIEWS
- Knockout of HIF-1 in tumor-associated macrophages enhances M2 polarization and attenuates their pro-angiogenic responses
- (2010) C. Werno et al. CARCINOGENESIS
- Differential activation and antagonistic function of HIF- isoforms in macrophages are essential for NO homeostasis
- (2010) N. Takeda et al. GENES & DEVELOPMENT
- STAT6 Transcription Factor Is a Facilitator of the Nuclear Receptor PPARγ-Regulated Gene Expression in Macrophages and Dendritic Cells
- (2010) Attila Szanto et al. IMMUNITY
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes
- (2010) Josef Ecker et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Epigenetic regulation of the alternatively activated macrophage phenotype
- (2009) M. Ishii et al. BLOOD
- Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
- (2009) H.-Y. Fang et al. BLOOD
- Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo
- (2009) Ramon C. Sun et al. BREAST CANCER RESEARCH AND TREATMENT
- Glycolytic control of adjuvant-induced macrophage survival: role of PI3K, MEK1/2, and Bcl-2
- (2009) Margaret Chang et al. JOURNAL OF LEUKOCYTE BIOLOGY
- A CREB-C/EBP cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair
- (2009) D. Ruffell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of mTOR in the management of solid tumors: An overview
- (2008) Alex S. Strimpakos et al. CANCER TREATMENT REVIEWS
- PX-478, an inhibitor of hypoxia-inducible factor-1α, enhances radiosensitivity of prostate carcinoma cells
- (2008) Sanjeewani T. Palayoor et al. INTERNATIONAL JOURNAL OF CANCER
- Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1
- (2008) M. Y. Koh et al. MOLECULAR CANCER THERAPEUTICS
- Macrophage activation and polarization
- (2007) Fernando Oneissi Martinez Frontiers in Bioscience-Landmark
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now