N-cadherin in cancer metastasis, its emerging role in haematological malignancies and potential as a therapeutic target in cancer

Prognostic Role of N-cadherin Expression in Patients With Invasive Bladder Cancer

(2018) Mohammad Abufaraj et al.   Clinical Genitourinary Cancer

Upregulated N-cadherin expression is associated with poor prognosis in epithelial-derived solid tumours: A meta-analysis

(2018) Yong Luo et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Adjustable viscoelasticity allows for efficient collective cell migration

(2018) Elias H. Barriga et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A central role for cadherin signaling in cancer

(2017) Antonis Kourtidis et al.   EXPERIMENTAL CELL RESEARCH

Clinical significance of altering epithelial–mesenchymal transition in metastatic lymph nodes of gastric cancer

(2017) Keishi Okubo et al.   Gastric Cancer

Clinical significance of epithelial-to-mesenchymal transition in laryngeal carcinoma: Its role in the different subsites

(2017) Silvia Mezi et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific

(2017) Francesca Fontana et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single and collective cell migration: the mechanics of adhesions

(2017) Chiara De Pascalis et al.   MOLECULAR BIOLOGY OF THE CELL

Understanding of leukemic stem cells and their clinical implications

(2017) Xuefei Wang et al.   Molecular Cancer

WNT signalling in prostate cancer

(2017) Virginia Murillo-Garzón et al.   Nature Reviews Urology

Cadherin composition and multicellular aggregate invasion in organotypic models of epithelial ovarian cancer intraperitoneal metastasis

(2017) Y Klymenko et al.   ONCOGENE

Three-dimensional biomimetic vascular model reveals a RhoA, Rac1, andN-cadherin balance in mural cell–endothelial cell-regulated barrier function

(2017) Stella Alimperti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of PAK1 Correlates with Aberrant Expression of EMT Markers and Poor Prognosis in Non-Small Cell Lung Cancer

(2017) Zhiying Yang et al.   Journal of Cancer

Wnt3a Expression Is Associated with Epithelial-Mesenchymal Transition and Impacts Prognosis of Lung Adenocarcinoma Patients

(2017) Jinming Xu et al.   Journal of Cancer

N-Cadherin Aided in Maintaining the Characteristics of Leukemic Stem Cells

(2016) Lei Zhi et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Deletion of the cytoplasmic domain of N-cadherin reduces, but does not eliminate, traction force-transmission

(2016) Eliot Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cancer cells remodel themselves and vasculature to overcome the endothelial barrier

(2016) Anitha K. Shenoy et al.   CANCER LETTERS

N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells

(2016) Brian D. Cosgrove et al.   NATURE MATERIALS

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FERMT1 mediates epithelial–mesenchymal transition to promote colon cancer metastasis via modulation of β-catenin transcriptional activity

(2016) C-C Liu et al.   ONCOGENE

Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer

(2016) Alexandros Drivalos et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Bone marrow niche-mediated survival of leukemia stem cells in acute myeloid leukemia: Yin and Yang

(2016) Hong-Sheng Zhou et al.   Cancer Biology & Medicine

Circulating Tumor Cell Composition in Renal Cell Carcinoma

(2016) Ivonne Nel et al.   PLoS One

Targeting N-cadherin Increases Vascular Permeability and Differentially Activates AKT in Melanoma

(2015) Ryan S. Turley et al.   ANNALS OF SURGERY

Markers of progression in early-stage invasive breast cancer: a predictive immunohistochemical panel algorithm for distant recurrence risk stratification

(2015) Mohammed A. Aleskandarany et al.   BREAST CANCER RESEARCH AND TREATMENT

Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion

(2015) Carole Siret et al.   BRITISH JOURNAL OF CANCER

Therapeutic targeting of N-cadherin is an effective treatment for multiple myeloma

(2015) Krzysztof M. Mrozik et al.   BRITISH JOURNAL OF HAEMATOLOGY

Modes of cancer cell invasion and the role of the microenvironment

(2015) Andrew G Clark et al.   CURRENT OPINION IN CELL BIOLOGY

Rho GTPase signalling in cell migration

(2015) Anne J Ridley   CURRENT OPINION IN CELL BIOLOGY

New Wnt/β-catenin target genes promote experimental metastasis and migration of colorectal cancer cells through different signals

(2015) Jingjing Qi et al.   GUT

β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia

(2015) A M Eiring et al.   LEUKEMIA

N-cadherin, a novel prognostic biomarker, drives malignant progression of colorectal cancer

(2015) XUEBING YAN et al.   Molecular Medicine Reports

Blocking the Adhesion Cascade at the Premetastatic Niche for Prevention of Breast Cancer Metastasis

(2015) Shin-Ae Kang et al.   MOLECULAR THERAPY

LPP inhibits collective cell migration during lung cancer dissemination

(2015) S Kuriyama et al.   ONCOGENE

Tetraspanin CD82 regulates bone marrow homing of acute myeloid leukemia by modulating the molecular organization of N-cadherin

(2015) K D Marjon et al.   ONCOGENE

N-cadherin functions as a growth suppressor in a model of K-ras-induced PanIN

(2015) Y Su et al.   ONCOGENE

Computational design of novel peptidomimetic inhibitors of cadherin homophilic interactions

(2015) Fabio Doro et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Epstein–Barr virus LMP1 induces focal adhesions and epithelial cell migration through effects on integrin-α5 and N-cadherin

(2015) L R Wasil et al.   Oncogenesis

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF- B mediates chemoresistance

(2014) R. Jacamo et al.   BLOOD

Epithelial mesenchymal transition in early invasive breast cancer: an immunohistochemical and reverse phase protein array study

(2014) Mohammed A. Aleskandarany et al.   BREAST CANCER RESEARCH AND TREATMENT

Neighborly relations during collective migration

(2014) Sandrine Etienne-Manneville   CURRENT OPINION IN CELL BIOLOGY

CD44 variant, but not standard CD44 isoforms, mediate disassembly of endothelial VE-cadherin junction on metastatic melanoma cells

(2014) Pu Zhang et al.   FEBS LETTERS

microRNA-194 suppresses osteosarcoma cell proliferation and metastasis in vitro and in vivo by targeting CDH2 and IGF1R

(2014) KANG HAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Strong correlation between N-cadherin and CD133 in breast cancer: role of both markers in metastatic events

(2014) Carolin Bock et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

N-Cadherin and Tie2 positive CD34+CD38−CD123+ leukemic stem cell populations can develop acute myeloid leukemia more effectively in NOD/SCID mice

(2014) Shaowei Qiu et al.   LEUKEMIA RESEARCH

N-cadherin and P-cadherin are biomarkers for invasion, metastasis, and poor prognosis of gallbladder carcinomas

(2014) Shengen Yi et al.   PATHOLOGY RESEARCH AND PRACTICE

N-cadherin antagonists as oncology therapeutics

(2014) O. W. Blaschuk   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Detection of Circulating Tumor Cell Subpopulations in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)

(2014) Patrick Weller et al.   PLoS One

Integrin alpha4 blockade sensitizes drug resistant pre-B acute lymphoblastic leukemia to chemotherapy

(2013) Y.-T. Hsieh et al.   BLOOD

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt- -catenin signaling

(2013) B. Zhang et al.   BLOOD

Soluble Neural-cadherin as a novel biomarker for malignant bone and soft tissue tumors

(2013) Rui Niimi et al.   BMC CANCER

E- to N-cadherin switch in melanoma is associated with decreased expression of phosphatase and tensin homolog and cancer progression

(2013) J. Lade-Keller et al.   BRITISH JOURNAL OF DERMATOLOGY

Circulating N-cadherin levels are a negative prognostic indicator in patients with multiple myeloma

(2013) Kate Vandyke et al.   BRITISH JOURNAL OF HAEMATOLOGY

Myeloproliferative Neoplasia Remodels the Endosteal Bone Marrow Niche into a Self-Reinforcing Leukemic Niche

(2013) Koen Schepers et al.   Cell Stem Cell

Epithelial-mesenchymal transition increases during the progression of in situ to invasive basal-like breast cancer

(2013) Yoomi Choi et al.   HUMAN PATHOLOGY

Signalling pathways linking integrins with cell cycle progression

(2013) Paulina Moreno-Layseca et al.   MATRIX BIOLOGY

Interleukin-6-induced Twist and N-cadherin enhance melanoma cell metastasis

(2013) Yi-Rang Na et al.   MELANOMA RESEARCH

DKK1 promotes hepatocellular carcinoma cell migration and invasion through β-catenin/MMP7 signaling pathway

(2013) Liang Chen et al.   Molecular Cancer

N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties

(2013) X Qian et al.   ONCOGENE

Slug is a key mediator of hypoxia induced cadherin switch in HNSCC: Correlations with poor prognosis

(2013) Jiali Zhang et al.   ORAL ONCOLOGY

N-Cadherin Expression Is Associated with Acquisition of EMT Phenotype and with Enhanced Invasion in Erlotinib-Resistant Lung Cancer Cell Lines

(2013) Xiaoju Zhang et al.   PLoS One

Prognostic Significance of Twist and N-Cadherin Expression in NSCLC

(2013) Linping Hui et al.   PLoS One

Vascular Endothelial Growth Factor Receptor-1 Activation Promotes Migration and Invasion of Breast Cancer Cells through Epithelial-Mesenchymal Transition

(2013) Qian Ning et al.   PLoS One

N-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways

(2013) Mingxing Ouyang et al.   Nature Communications

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells

(2012) A. M. Greenbaum et al.   BLOOD

Myeloma as a model for the process of metastasis: implications for therapy

(2012) I. M. Ghobrial   BLOOD

Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells

(2012) O. Bromberg et al.   BLOOD

Cadherin switch from E- to N-cadherin in melanoma progression is regulated by the PI3K/PTEN pathway through Twist and Snail

(2012) L. Hao et al.   BRITISH JOURNAL OF DERMATOLOGY

Expression of cell adhesion molecules and prognosis in breast cancer

(2012) S. Saadatmand et al.   BRITISH JOURNAL OF SURGERY

MUC4 potentiates invasion and metastasis of pancreatic cancer cells through stabilization of fibroblast growth factor receptor 1

(2012) Satyanarayana Rachagani et al.   CARCINOGENESIS

The many faces and functions of β-catenin

(2012) Tomas Valenta et al.   EMBO JOURNAL

Nuclear expression of N-cadherin correlates with poor prognosis of nasopharyngeal carcinoma

(2012) Wei-Ren Luo et al.   HISTOPATHOLOGY

N-cadherin-mediated cell-cell adhesion promotes cell migration in a three-dimensional matrix

(2012) W. Shih et al.   JOURNAL OF CELL SCIENCE

Expression of Wnt3 Activates Wnt/ -Catenin Pathway and Promotes EMT-like Phenotype in Trastuzumab-Resistant HER2-Overexpressing Breast Cancer Cells

(2012) Y. Wu et al.   MOLECULAR CANCER RESEARCH

Clinical implications of N-cadherin expression in gastric cancer

(2012) Takahito Kamikihara et al.   PATHOLOGY INTERNATIONAL

N-Cadherin in Neuroblastoma Disease: Expression and Clinical Significance

(2012) Tim Lammens et al.   PLoS One

Clinicopathological and prognostic significance of epithelial mesenchymal transition-related protein expression in intrahepatic cholangiocarcinoma

(2012) Xing Yao et al.   OncoTargets and Therapy

Tug of war in the haematopoietic stem cell niche: do myeloma plasma cells compete for the HSC niche?

(2012) J E Noll et al.   Blood Cancer Journal

Cardiac myocyte remodeling mediated by N-cadherin-dependent mechanosensing

(2011) Anant Chopra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

E/N-cadherin switch mediates cancer progression via TGF-β-induced epithelial-to-mesenchymal transition in extrahepatic cholangiocarcinoma

(2011) K Araki et al.   BRITISH JOURNAL OF CANCER

Androgen Deprivation Causes Epithelial-Mesenchymal Transition in the Prostate: Implications for Androgen-Deprivation Therapy

(2011) Y. Sun et al.   CANCER RESEARCH

Cancer Invasion and the Microenvironment: Plasticity and Reciprocity

(2011) Peter Friedl et al.   CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

N-cadherin-mediated interaction with multiple myeloma cells inhibits osteoblast differentiation

(2011) R. W. J. Groen et al.   HAEMATOLOGICA

Cisplatin treatment of primary and metastatic epithelial ovarian carcinomas generates residual cells with mesenchymal stem cell-like profile

(2011) Ardian Latifi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Prospective Multicenter Phase II Trial of Systemic ADH-1 in Combination With Melphalan via Isolated Limb Infusion in Patients With Advanced Extremity Melanoma

(2011) Georgia M. Beasley et al.   JOURNAL OF CLINICAL ONCOLOGY

N-cadherin haploinsufficiency increases survival in a mouse model of pancreatic cancer

(2011) Y Su et al.   ONCOGENE

Tissue Organization by Cadherin Adhesion Molecules: Dynamic Molecular and Cellular Mechanisms of Morphogenetic Regulation

(2011) Carien M. Niessen et al.   PHYSIOLOGICAL REVIEWS

The Extracellular Architecture of Adherens Junctions Revealed by Crystal Structures of Type I Cadherins

(2011) Oliver J. Harrison et al.   STRUCTURE

Expression Profile of E-cadherin and N-cadherin in Urothelial Carcinoma of the Upper Urinary Tract is Associated with Disease Recurrence in Patients Undergoing Nephroureterectomy

(2011) Mototsugu Muramaki et al.   UROLOGY

The cadherin switch in ovarian high-grade serous carcinoma is associated with disease progression

(2011) Livia Quattrocchi et al.   VIRCHOWS ARCHIV

Enrichment of N-Cadherin and Tie2-bearing CD34+/CD38−/CD123+ leukemic stem cells by chemotherapy-resistance

(2010) Lei Zhi et al.   CANCER LETTERS

Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow

(2010) Kentaro Hosokawa et al.   Cell Stem Cell

Collective Chemotaxis Requires Contact-Dependent Cell Polarity

(2010) Eric Theveneau et al.   DEVELOPMENTAL CELL

N-cadherin increases after androgen deprivation and is associated with metastasis in prostate cancer

(2010) Karin Jennbacken et al.   ENDOCRINE-RELATED CANCER

Monoclonal antibody targeting of N-cadherin inhibits prostate cancer growth, metastasis and castration resistance

(2010) Hiroshi Tanaka et al.   NATURE MEDICINE

Adhesion molecules—The lifelines of multiple myeloma cells

(2010) Ben-Zion Katz   SEMINARS IN CANCER BIOLOGY

Expression profile of E-cadherin and N-cadherin in non-muscle-invasive bladder cancer as a novel predictor of intravesical recurrence following transurethral resection

(2010) Mototsugu Muramaki et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Clinical and pharmacological phase I evaluation of ExherinTM (ADH-1), a selective anti-N-cadherin peptide in patients with N-cadherin-expressing solid tumours

(2009) A. Perotti et al.   ANNALS OF ONCOLOGY

Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

(2009) A. V. Kurtova et al.   BLOOD

A phase 1 study of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with locally advanced in-transit malignant melanoma

(2009) Georgia M. Beasley et al.   CANCER

Epithelial-Mesenchymal Transitions in Development and Disease

(2009) Jean Paul Thiery et al.   CELL

Hematopoietic Stem Cells Do Not Depend on N-Cadherin to Regulate Their Maintenance

(2009) Mark J. Kiel et al.   Cell Stem Cell

N-cadherin/p120 Catenin Association at Cell-Cell Contacts Occurs in Cholesterol-rich Membrane Domains and Is Required for RhoA Activation and Myogenesis

(2009) Nicolas Taulet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Homotypic Cell-Cell Adhesion by BranchedN-Glycosylation of N-cadherin Extracellular EC2 and EC3 Domains

(2009) Hua-Bei Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel peptide mimetic small molecules of the HAV motif in N-cadherin inhibit N-cadherin-mediated neurite outgrowth and cell adhesion

(2009) Susan M. Burden-Gulley et al.   PEPTIDES

Interplay of Cadherin-Mediated Cell Adhesion and Canonical Wnt Signaling

(2009) J. Heuberger et al.   Cold Spring Harbor Perspectives in Biology

Deletion of the WNT Target and Cancer Stem Cell Marker CD44 in Apc(Min/+) Mice Attenuates Intestinal Tumorigenesis

(2008) J. Zeilstra et al.   CANCER RESEARCH

Targeting N-Cadherin Enhances Antitumor Activity of Cytotoxic Therapies in Melanoma Treatment

(2008) C. K. Augustine et al.   CANCER RESEARCH

Homotypic and Endothelial Cell Adhesions via N-Cadherin Determine Polarity and Regulate Migration of Vascular Smooth Muscle Cells

(2008) Peter J.B. Sabatini et al.   CIRCULATION RESEARCH

Cadherin switching

(2008) M. J. Wheelock et al.   JOURNAL OF CELL SCIENCE

Identification of a novel N-cadherin antagonist

(2008) Emmanuelle Devemy et al.   PEPTIDES

CD44v4 Is a Major E-Selectin Ligand that Mediates Breast Cancer Cell Transendothelial Migration

(2008) Ke Zen et al.   PLoS One

Leukemic Cells Create Bone Marrow Niches That Disrupt the Behavior of Normal Hematopoietic Progenitor Cells

(2008) Angela Colmone et al.   SCIENCE

Phospho-Akt pathway activation and inhibition depends on N-cadherin or phospho-EGFR expression in invasive human bladder cancer cell lines

(2008) Hervé Wallerand et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

The multiple myeloma associated MMSET gene contributes to cellular adhesion, clonogenic growth, and tumorigenicity

(2007) J. Lauring et al.   BLOOD