An update in club cell biology and its potential relevance to chronic obstructive pulmonary disease

A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease

(2023) Samir Rustam et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

(2022) Preetish Kadur Lakshminarasimha Murthy et al.   NATURE

Human distal airways contain a multipotent secretory cell that can regenerate alveoli

(2022) Maria C. Basil et al.   NATURE

Secretory Cells are the Primary Source of pIgR in Small Airways

(2022) Jessica B Blackburn et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages

(2021) Els Wauters et al.   CELL RESEARCH

Integrative analysis of cell state changes in lung fibrosis with peripheral protein biomarkers

(2021) Christoph H Mayr et al.   EMBO Molecular Medicine

COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets

(2021) Toni M. Delorey et al.   NATURE

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

(2021) Gianni Carraro et al.   NATURE MEDICINE

Small airway determinants of airflow limitation in chronic obstructive pulmonary disease

(2021) Vasiliy V Polosukhin et al.   THORAX

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

(2021) Ruchi Kumari et al.   Frontiers in Cell and Developmental Biology

Cigarette Smoke Specifically Affects Small Airway Epithelial Cell Populations and Triggers the Expansion of Inflammatory and Squamous Differentiation Associated Basal Cells

(2021) Christian T. Wohnhaas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Smoking shifts human small airway epithelium club cells toward a lesser differentiated population

(2021) Mahboubeh R. Rostami et al.   npj Genomic Medicine

Sustained Club Cell Injury in Mice Induces Histopathologic Features of Deployment-Related Constrictive Bronchiolitis

(2021) Seagal Teitz-Tennenbaum et al.   AMERICAN JOURNAL OF PATHOLOGY

Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration

(2020) Jaymin J. Kathiriya et al.   Cell Stem Cell

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

(2020) Ashley M. Laughney et al.   NATURE MEDICINE

Bi-directional differentiation of single bronchioalveolar stem cells during lung repair

(2020) Kuo Liu et al.   Cell Discovery

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

(2020) Wei Rao et al.   CELL

SARS ‐CoV‐2 receptor ACE 2 and TMPRSS 2 are primarily expressed in bronchial transient secretory cells

(2020) Soeren Lukassen et al.   EMBO JOURNAL

Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium

(2020) Katherine C. Goldfarbmuren et al.   Nature Communications

Role of p53 in the Regulation of Cellular Senescence

(2020) Mahmut Mijit et al.   Biomolecules

A Single-cell Atlas of the Human Healthy Airways

(2020) Marie Deprez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis

(2020) Arun C. Habermann et al.   Science Advances

Monocyte-derived dendritic cells link localized secretory IgA deficiency to adaptive immune activation in COPD

(2020) Bradley W. Richmond et al.   Mucosal Immunology

Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia

(2020) Kenichi Okuda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Flow Cytometric Analysis and Purification of Airway Epithelial Cell Subsets

(2020) Luke R Bonser et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

Lung transplantation for patients with severe COVID-19

(2020) Ankit Bharat et al.   Science Translational Medicine

Cellular Senescence as a Mechanism and Target in Chronic Lung Diseases

(2019) Peter J Barnes et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia in vivo

(2019) Isabelle Salwig et al.   EMBO JOURNAL

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease

(2019) Eleanor Valenzi et al.   ANNALS OF THE RHEUMATIC DISEASES

IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis

(2019) Gang Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Update on Clinical Aspects of Chronic Obstructive Pulmonary Disease

(2019) Bartolomé R. Celli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Altered generation of ciliated cells in chronic obstructive pulmonary disease

(2019) Sophie Gohy et al.   Scientific Reports

Characterizing smoking-induced transcriptional heterogeneity in the human bronchial epithelium at single-cell resolution

(2019) Grant E. Duclos et al.   Science Advances

Ontogeny and Biology of Human Small Airway Epithelial Club Cells

(2018) Wu-Lin Zuo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease

(2018) Moumita Ghosh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease

(2018) Bradley W. Richmond et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Genetic Ablation of p16(Ink4a) Does Not Protect Against Cellular Senescence in Mouse Models of COPD/Emphysema

(2018) Isaac K Sundar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Phenotype molding of stromal cells in the lung tumor microenvironment

(2018) Diether Lambrechts et al.   NATURE MEDICINE

NOTCH3 contributes to rhinovirus-induced goblet cell hyperplasia in COPD airway epithelial cells

(2018) Yaxun Jing et al.   THORAX

p53 in Bronchial Club Cells Facilitates Chronic Lung Inflammation by Promoting Senescence

(2018) Adi Sagiv et al.   Cell Reports

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(2018) Lindsey W. Plasschaert et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis

(2018) Paul A Reyfman et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways

(2018) Kenichi Okuda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Xenobiotic metabolism in differentiated human bronchial epithelial cells

(2016) Jan J. W. A. Boei et al.   ARCHIVES OF TOXICOLOGY

Secretoglobin Superfamily Protein SCGB3A2 Alleviates House Dust Mite-Induced Allergic Airway Inflammation in Mice

(2016) Mitsuhiro Yoneda et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

The role and importance of club cells (Clara cells) in the pathogenesis of some respiratory diseases

(2016) Wojciech Rokicki et al.   Kardiochirurgia i Torakochirurgia Polska

Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency

(2016) Bradley W. Richmond et al.   Nature Communications

Protective role for club cell secretory protein-16 (CC16) in the development of COPD

(2015) Maria E. Laucho-Contreras et al.   EUROPEAN RESPIRATORY JOURNAL

Chronic obstructive pulmonary disease

(2015) Peter J. Barnes et al.   Nature Reviews Disease Primers

Airway Basal Stem/Progenitor Cells Have Diminished Capacity to Regenerate Airway Epithelium in Chronic Obstructive Pulmonary Disease

(2014) Michelle R. Staudt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Secretoglobin Superfamily Protein SCGB3A2 Deficiency Potentiates Ovalbumin-Induced Allergic Pulmonary Inflammation

(2014) Taketomo Kido et al.   MEDIATORS OF INFLAMMATION

Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice

(2014) Shyamala Ganesan et al.   RESPIRATORY RESEARCH

Dedifferentiation of committed epithelial cells into stem cells in vivo

(2013) Purushothama Rao Tata et al.   NATURE

Pathogenesis of chronic obstructive pulmonary disease

(2012) Rubin M. Tuder et al.   JOURNAL OF CLINICAL INVESTIGATION

Computed tomography–based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression

(2012) Craig J Galbán et al.   NATURE MEDICINE

Neuroepithelial body microenvironment is a niche for a distinct subset of Clara-like precursors in the developing airways

(2012) A. Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bronchial Secretory Immunoglobulin A Deficiency Correlates With Airway Inflammation and Progression of Chronic Obstructive Pulmonary Disease

(2011) Vasiliy V. Polosukhin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Conditional Depletion of Airway Progenitor Cells Induces Peribronchiolar Fibrosis

(2010) Anne-Karina T. Perl et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Goblet Cells Are Derived from aFOXJ1-Expressing Progenitor in a Human Airway Epithelium

(2010) Jonathan Turner et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The Clara cell: a "Third Reich eponym"?

(2010) A. Winkelmann et al.   EUROPEAN RESPIRATORY JOURNAL

Cigarette smoke-induced emphysema in A/J mice is associated with pulmonary oxidative stress, apoptosis of lung cells, and global alterations in gene expression

(2009) Tirumalai Rangasamy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Role of Scgb1a1+ Clara Cells in the Long-Term Maintenance and Repair of Lung Airway, but Not Alveolar, Epithelium

(2009) Emma L. Rawlins et al.   Cell Stem Cell

NUCLEAR FACTOR KAPPA B INDUCTION IN AIRWAY EPITHELIUM INCREASES LUNG INFLAMMATION IN ALLERGEN-CHALLENGED MICE

(2009) James R. Sheller et al.   EXPERIMENTAL LUNG RESEARCH

Clara cell: Progenitor for the bronchiolar epithelium

(2009) Susan D. Reynolds et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Basal cells as stem cells of the mouse trachea and human airway epithelium

(2009) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA