A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease

Human distal lung maps and lineage hierarchies reveal a bipotent progenitor

(2022) Preetish Kadur Lakshminarasimha Murthy et al.   NATURE

Human distal airways contain a multipotent secretory cell that can regenerate alveoli

(2022) Maria C. Basil et al.   NATURE

Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition

(2021) Gianni Carraro et al.   NATURE MEDICINE

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Integrated Single-Cell Atlas of Endothelial Cells of the Human Lung

(2021) Jonas C. Schupp et al.   CIRCULATION

The molecular and cellular mechanisms associated with the destruction of terminal bronchioles in chronic obstructive pulmonary disease

(2021) Feng Xu et al.   EUROPEAN RESPIRATORY JOURNAL

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

(2020) Wei Rao et al.   CELL

A Single-cell Atlas of the Human Healthy Airways

(2020) Marie Deprez et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis

(2020) Maximilian Strunz et al.   Nature Communications

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosis

(2020) Taylor S. Adams et al.   Science Advances

Capillary cell-type specialization in the alveolus

(2020) Astrid Gillich et al.   NATURE

A molecular cell atlas of the human lung from single-cell RNA sequencing

(2020) Kyle J. Travaglini et al.   NATURE

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics

(2019) Ilias Angelidis et al.   Nature Communications

Non-Invasive Imaging Biomarker Identifies Small Airway Damage in Severe COPD

(2019) Dragos M Vasilescu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

(2019) Christopher S. McGinnis et al.   Cell Systems

A cellular census of human lungs identifies novel cell states in health and in asthma

(2019) Felipe A. Vieira Braga et al.   NATURE MEDICINE

Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures

(2019) Sandra Ruiz García et al.   DEVELOPMENT

Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

(2019) Peter A. Szabo et al.   Nature Communications

Airway Epithelial Progenitors and the Natural History of Chronic Obstructive Pulmonary Disease

(2018) Renat Shaykhiev   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Analysis of airway pathology in COPD using a combination of computed tomography, micro-computed tomography and histology

(2018) Naoya Tanabe et al.   EUROPEAN RESPIRATORY JOURNAL

Human T Cell Development, Localization, and Function throughout Life

(2018) Brahma V. Kumar et al.   IMMUNITY

Small airways disease in mild and moderate chronic obstructive pulmonary disease: a cross-sectional study

(2018) Hyun-Kyoung Koo et al.   Lancet Respiratory Medicine

A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

(2018) Lindsey W. Plasschaert et al.   NATURE

A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

(2018) Daniel T. Montoro et al.   NATURE

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways

(2018) Kenichi Okuda et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Human Tissue-Resident Memory T Cells Are Defined by Core Transcriptional and Functional Signatures in Lymphoid and Mucosal Sites

(2017) Brahma V. Kumar et al.   Cell Reports

Association between Functional Small Airway Disease and FEV1Decline in Chronic Obstructive Pulmonary Disease

(2016) Surya P. Bhatt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

EGF-Amphiregulin Interplay in Airway Stem/Progenitor Cells Links the Pathogenesis of Smoking-Induced Lesions in the Human Airway Epithelium

(2016) Wu-Lin Zuo et al.   STEM CELLS

Schwann Cells: Development and Role in Nerve Repair

(2015) Kristján R. Jessen et al.   Cold Spring Harbor Perspectives in Biology

Airway Basal Stem/Progenitor Cells Have Diminished Capacity to Regenerate Airway Epithelium in Chronic Obstructive Pulmonary Disease

(2014) Michelle R. Staudt et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

EGF shifts human airway basal cell fate toward a smoking-associated airway epithelial phenotype

(2013) R. Shaykhiev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast Cell Infiltration Discriminates between Histopathological Phenotypes of Chronic Obstructive Pulmonary Disease

(2012) Andrea Ballarin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Computed tomography–based biomarker provides unique signature for diagnosis of COPD phenotypes and disease progression

(2012) Craig J Galbán et al.   NATURE MEDICINE

Distal Airway Stem Cells Yield Alveoli In Vitro and during Lung Regeneration following H1N1 Influenza Infection

(2011) Pooja A. Kumar et al.   CELL

Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease

(2011) John E. McDonough et al.   NEW ENGLAND JOURNAL OF MEDICINE

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling

(2010) J. R. Rock et al.   Disease Models & Mechanisms