Xenobiotic metabolism in differentiated human bronchial epithelial cells

Azithromycin differentially affects the IL-13-induced expression profile in human bronchial epithelial cells

(2016) Tinne C.J. Mertens et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Identification of amino acid determinants in CYP4B1 for optimal catalytic processing of 4-ipomeanol

(2015) Constanze Wiek et al.   BIOCHEMICAL JOURNAL

Basal Cells Contribute to Innate Immunity of the Airway Epithelium through Production of the Antimicrobial Protein RNase 7

(2015) Gimano D. Amatngalim et al.   JOURNAL OF IMMUNOLOGY

Impact Assessment of Cigarette Smoke Exposure on Organotypic Bronchial Epithelial Tissue Cultures: A Comparison of Mono-Culture and Coculture Model Containing Fibroblasts

(2015) Anita R. Iskandar et al.   TOXICOLOGICAL SCIENCES

Targeted omics analyses, and metabolic enzyme activity assays demonstrate maintenance of key mucociliary characteristics in long term cultures of reconstituted human airway epithelia

(2015) Andrew Baxter et al.   TOXICOLOGY IN VITRO

Biological impact of cigarette smoke compared to an aerosol produced from a prototypic modified risk tobacco product on normal human bronchial epithelial cells

(2015) U. Kogel et al.   TOXICOLOGY IN VITRO

Development of an in vitro cytotoxicity model for aerosol exposure using 3D reconstructed human airway tissue; application for assessment of e-cigarette aerosol

(2015) Louise Neilson et al.   TOXICOLOGY IN VITRO

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke

(2015) Diana Kuehn et al.   Jove-Journal of Visualized Experiments

diXa: a data infrastructure for chemical safety assessment

(2014) Diana M. Hendrickx et al.   BIOINFORMATICS

The Response of Human Nasal and Bronchial Organotypic Tissue Cultures to Repeated Whole Cigarette Smoke Exposure

(2014) Marja Talikka et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

Human bronchial epithelial cells exposed in vitro to cigarette smoke at the air-liquid interface resemble bronchial epithelium from human smokers

(2013) Carole Mathis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pilot Study of CYP2B6 Genetic Variation to Explore the Contribution of Nitrosamine Activation to Lung Carcinogenesis

(2013) Catherine Wassenaar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Studies of styrene, styrene oxide and 4-hydroxystyrene toxicity in CYP2F2 knockout and CYP2F1 humanized mice support lack of human relevance for mouse lung tumors

(2013) G. Cruzan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Generation and Characterization of a Cyp4b1 Null Mouse and the Role of CYP4B1 in the Activation and Toxicity of Ipomeanol

(2013) Oliver T. Parkinson et al.   TOXICOLOGICAL SCIENCES

Xenobiotic metabolism and disposition in human lung: Transcript profiling in non-tumoral and tumoral tissues

(2011) Julie Leclerc et al.   BIOCHIMIE

CYP2F2-generated metabolites, not styrene oxide, are a key event mediating the mode of action of styrene-induced mouse lung tumors

(2011) G. Cruzan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

CYP1A1/1B1 and CYP2A6/2A13 activity is conserved in cultures of differentiated primary human tracheobronchial epithelial cells

(2011) Nik Newland et al.   TOXICOLOGY IN VITRO

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

(2010) Alejandro A. Pezzulo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Cytochrome P450–Mediated Pulmonary Metabolism of Carcinogens

(2010) Sisko Anttila et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Do Airway Epithelium Air–Liquid Cultures Represent theIn VivoAirway Epithelium Transcriptome?

(2010) Anna Dvorak et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Cytochrome P450 enzymes involved in the metabolism of aflatoxin B1 in chickens and quail

(2010) G. J. Diaz et al.   POULTRY SCIENCE

Comparison of HepG2 and HepaRG by Whole-Genome Gene Expression Analysis for the Purpose of Chemical Hazard Identification

(2010) Danyel G. J. Jennen et al.   TOXICOLOGICAL SCIENCES

Troubleshooting methods for toxicity testing of airborne chemicals in vitro

(2010) Shahnaz Bakand et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Impact of Multiple Alcohol Dehydrogenase Gene Polymorphisms on Risk of Upper Aerodigestive Tract Cancers in a Japanese Population

(2009) I. Oze et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions

(2009) Saskia Preissner et al.   NUCLEIC ACIDS RESEARCH

Mouse specific lung tumors from CYP2F2-mediated cytotoxic metabolism: An endpoint/toxic response where data from multiple chemicals converge to support a mode of action

(2009) George Cruzan et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

(2008) Petr Pavek et al.   CURRENT DRUG METABOLISM