Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway
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Title
Cell-Permeable PROTAC Degraders against KEAP1 Efficiently Suppress Hepatic Stellate Cell Activation through the Antioxidant and Anti-Inflammatory Pathway
Authors
Keywords
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Journal
ACS Pharmacology & Translational Science
Volume 6, Issue 1, Pages 76-87
Publisher
American Chemical Society (ACS)
Online
2022-12-08
DOI
10.1021/acsptsci.2c00165
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Note: Only part of the references are listed.- Improved transfer efficiency of supercharged 36 + GFP protein mediate nucleic acid delivery
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- (2021) Minkyung Baek et al. SCIENCE
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- (2021) Jingping Geng et al. JOURNAL OF CONTROLLED RELEASE
- Computed structures of core eukaryotic protein complexes
- (2021) Ian R. Humphreys et al. SCIENCE
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- (2020) Jingping Geng et al. Biomolecules
- Current strategies in extending half-lives of therapeutic proteins
- (2019) Rahela Zaman et al. JOURNAL OF CONTROLLED RELEASE
- Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs
- (2019) Miriam Girardini et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Analysis of distance‐based protein structure prediction by deep learning in CASP13
- (2019) Jinbo Xu et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Nrf2-Keap1 signaling in oxidative and reductive stress
- (2018) Ilaria Bellezza et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Protective effect of ethyl acetate fraction of Drynaria quercifolia against CCl 4 induced rat liver fibrosis via Nrf2/ARE and NFκB signalling pathway
- (2018) G.I. Anuja et al. JOURNAL OF ETHNOPHARMACOLOGY
- Machine-Learning-Based Prediction of Cell-Penetrating Peptides and Their Uptake Efficiency with Improved Accuracy
- (2018) Balachandran Manavalan et al. JOURNAL OF PROTEOME RESEARCH
- Prediction of Cell-Penetrating Potential of Modified Peptides Containing Natural and Chemically Modified Residues
- (2018) Vinod Kumar et al. Frontiers in Microbiology
- Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice
- (2018) Jing Liu et al. Frontiers in Pharmacology
- Homo-PROTACs for the Chemical Knockdown of Cereblon
- (2018) Christian Steinebach et al. ACS Chemical Biology
- Mitochondrial-targeted penetrating peptide delivery for cancer therapy
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- Novel peptide MT23 for potent penetrating and selective targeting in mouse melanoma cancer cells
- (2017) Nan Zhou et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Evaluation of the effect of d-amino acid incorporation into amyloid-reactive peptides
- (2017) Emily B. Martin et al. Journal of Translational Medicine
- The ClusPro web server for protein–protein docking
- (2017) Dima Kozakov et al. Nature Protocols
- Mechanisms of hepatic stellate cell activation
- (2017) Takuma Tsuchida et al. Nature Reviews Gastroenterology & Hepatology
- Inflammasomes in Liver Fibrosis
- (2017) Fernando Alegre et al. SEMINARS IN LIVER DISEASE
- Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
- (2017) Chiara Maniaci et al. Nature Communications
- Accurate De Novo Prediction of Protein Contact Map by Ultra-Deep Learning Model
- (2017) Sheng Wang et al. PLoS Computational Biology
- Prediction of cell-penetrating peptides with feature selection techniques
- (2016) Hua Tang et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- CXCL6 promotes human hepatocyte proliferation through the CXCR1–NFκB pathway and inhibits collagen I secretion by hepatic stellate cells
- (2016) Zhenghong Li et al. Biochemistry and Cell Biology
- Highly Efficient Delivery of Functional Cargoes by a Novel Cell-Penetrating Peptide Derived from SP140-Like Protein
- (2016) Hu Wang et al. BIOCONJUGATE CHEMISTRY
- Emerging landscape of cell penetrating peptide in reprogramming and gene editing
- (2016) Huiting Liu et al. JOURNAL OF CONTROLLED RELEASE
- The Keap1-Nrf2-ARE Pathway As a Potential Preventive and Therapeutic Target: An Update
- (2016) Meng-Chen Lu et al. MEDICINAL RESEARCH REVIEWS
- Signaling via the NFκB system
- (2016) Simon Mitchell et al. Wiley Interdisciplinary Reviews-Systems Biology and Medicine
- Efficient therapeutic delivery by a novel cell-permeant peptide derived from KDM4A protein for antitumor and antifibrosis
- (2016) Hu Wang et al. Oncotarget
- Hyperosmotic treatment synergistically boost efficiency of cell-permeable peptides
- (2016) Hu Wang et al. Oncotarget
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- Mechanisms of liver fibrosis resolution
- (2015) Frank Tacke et al. JOURNAL OF HEPATOLOGY
- Enhanced Peptide Delivery into Cells by Using the Synergistic Effects of a Cell-Penetrating Peptide and a Chemical Drug to Alter Cell Permeability
- (2015) Jie-Lan Ma et al. MOLECULAR PHARMACEUTICS
- Catalytic in vivo protein knockdown by small-molecule PROTACs
- (2015) Daniel P Bondeson et al. Nature Chemical Biology
- The I-TASSER Suite: protein structure and function prediction
- (2015) Jianyi Yang et al. NATURE METHODS
- I-TASSER server: new development for protein structure and function predictions
- (2015) Jianyi Yang et al. NUCLEIC ACIDS RESEARCH
- Phthalimide conjugation as a strategy for in vivo target protein degradation
- (2015) G. E. Winter et al. SCIENCE
- Liver fibrosis markers in alcoholic liver disease
- (2014) Lech Chrostek WORLD JOURNAL OF GASTROENTEROLOGY
- Hepatic stellate cells in liver development, regeneration, and cancer
- (2013) Chunyue Yin et al. JOURNAL OF CLINICAL INVESTIGATION
- Mechanism and Significance of Changes in Glutamate-Cysteine Ligase Expression during Hepatic Fibrogenesis
- (2012) Komal Ramani et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Butein inhibits ethanol-induced activation of liver stellate cells through TGF-β, NFκB, p38, and JNK signaling pathways and inhibition of oxidative stress
- (2012) Agnieszka Szuster-Ciesielska et al. JOURNAL OF GASTROENTEROLOGY
- Targeting the von Hippel–Lindau E3 Ubiquitin Ligase Using Small Molecules To Disrupt the VHL/HIF-1α Interaction
- (2012) Dennis L. Buckley et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
- (2012) Sadagopan Magesh et al. MEDICINAL RESEARCH REVIEWS
- In silico predictions of 3D structures of linear and cyclic peptides with natural and non-proteinogenic residues
- (2011) Jérôme Beaufays et al. JOURNAL OF PEPTIDE SCIENCE
- Current status of novel antifibrotic therapies in patients with chronic liver disease
- (2011) Michal Cohen-Naftaly et al. Therapeutic Advances in Gastroenterology
- Enhancement of TAT cell membrane penetration efficiency by dimethyl sulphoxide
- (2009) Hu Wang et al. JOURNAL OF CONTROLLED RELEASE
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