The Need for Biomarkers in the ALS–FTD Spectrum: A Clinical Point of View on the Role of Proteomics

Brain metabolic connectivity reconfiguration in the semantic variant of primary progressive aphasia

(2022) Cecilia Boccalini et al.   CORTEX

The Role of Tau beyond Alzheimer’s Disease: A Narrative Review

(2022) Eleonora Virgilio et al.   Biomedicines

A pilot study using proximity extension assay of cerebrospinal fluid and its extracellular vesicles identifies novel amyotrophic lateral sclerosis biomarker candidates

(2022) Sebastian Sjoqvist et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Serum biomarkers of neuroinflammation and blood-brain barrier leakage in amyotrophic lateral sclerosis

(2022) Maize C. Cao et al.   BMC Neurology

From Biomarkers to Precision Medicine in Neurodegenerative Diseases: Where Are We?

(2022) Giacomo Tondo et al.   Journal of Clinical Medicine

Pharmacotherapy for Amyotrophic Lateral Sclerosis: A Review of Approved and Upcoming Agents

(2022) Stephen A. Johnson et al.   DRUGS

Amyotrophic lateral sclerosis

(2022) Eva L Feldman et al.   LANCET

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

(2021) Arpan R. Mehta et al.   ACTA NEUROPATHOLOGICA

Cognitive dysfunction in amyotrophic lateral sclerosis: can we predict it?

(2021) Fabiola De Marchi et al.   NEUROLOGICAL SCIENCES

Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations

(2021) Flora Cheng et al.   Frontiers in Molecular Neuroscience

Perturbations of the Proteome and of Secreted Metabolites in Primary Astrocytes from the hSOD1(G93A) ALS Mouse Model

(2021) Roberto Stella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomarkers for neurodegenerative diseases

(2021) Oskar Hansson   NATURE MEDICINE

Molecular Pathways Involved in Frontotemporal Lobar Degeneration with TDP-43 Proteinopathy: What Can We Learn from Proteomics?

(2021) Merel O. Mol et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

C9ORF72 Repeat Expansion Affects the Proteome of Primary Skin Fibroblasts in ALS

(2021) Marta Lualdi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Tau Isoforms and Proteolysis for Production of Toxic Tau Fragments in Neurodegeneration

(2021) Ben Boyarko et al.   Frontiers in Neuroscience

The impact of cognitive and behavioral impairment in amyotrophic lateral sclerosis

(2020) William Huynh et al.   Expert Review of Neurotherapeutics

Peptide variability and signatures associated with disease progression in CSF collected longitudinally from ALS patients

(2020) Allyson L. Mellinger et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Altered serum protein levels in frontotemporal dementia and amyotrophic lateral sclerosis indicate calcium and immunity dysregulation

(2020) Jared S. Katzeff et al.   Scientific Reports

Increased C-X-C Motif Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis

(2020) Pol Andrés-Benito et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics

(2019) Emma L. van der Ende et al.   Annals of Clinical and Translational Neurology

A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies

(2019) Daniela Perani et al.   Alzheimers & Dementia

The Need for Multi-Omics Biomarker Signatures in Precision Medicine

(2019) Michael Olivier et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD

(2019) Thomas J. Hedl et al.   Frontiers in Neuroscience

Targeted Multiple Reaction Monitoring Analysis of CSF Identifies UCHL1 and GPNMB as Candidate Biomarkers for ALS

(2019) Shaochun Zhu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mass spectrometry analysis of plasma from amyotrophic lateral sclerosis and control subjects

(2018) Zhouwei Xu et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Cellular Proteostasis in Neurodegeneration

(2018) Alberim Kurtishi et al.   MOLECULAR NEUROBIOLOGY

Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases

(2018) Claudio Soto et al.   NATURE NEUROSCIENCE

New Antibody-Free Mass Spectrometry-Based Quantification Reveals That C9ORF72 Long Protein Isoform Is Reduced in the Frontal Cortex of Hexanucleotide-Repeat Expansion Carriers

(2018) Arthur Viodé et al.   Frontiers in Neuroscience

RNA Binding Proteins and the Pathogenesis of Frontotemporal Lobar Degeneration

(2018) Jeffrey W. Hofmann et al.   Annual Review of Pathology-Mechanisms of Disease

Neuroanatomical Quantitative Proteomics Reveals Common Pathogenic Biological Routes between Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)

(2018) Marina Iridoy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Proteomics turns functional

(2018) Chiara Monti et al.   Journal of Proteomics

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype

(2017) Alison L. Hogan et al.   HUMAN MOLECULAR GENETICS

Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

(2017) Steven Boeynaems et al.   MOLECULAR CELL

Revisiting biomarker discovery by plasma proteomics

(2017) Philipp E Geyer et al.   Molecular Systems Biology

A clinicopathological approach to the diagnosis of dementia

(2017) Fanny M. Elahi et al.   Nature Reviews Neurology

Insights into the protective role of immunity in neurodegenerative disease

(2017) Cristoforo Comi et al.   Neural Regeneration Research

Frontotemporal Dementia

(2017) Nicholas T. Olney et al.   NEUROLOGIC CLINICS

Serum Proteome in a Sporadic Amyotrophic Lateral Sclerosis Geographical Cluster

(2017) Stefano De Benedetti et al.   Proteomics Clinical Applications

Amyotrophic lateral sclerosis

(2017) Orla Hardiman et al.   Nature Reviews Disease Primers

Semantic dementia and the left and right temporal lobes

(2017) Julie S. Snowden et al.   CORTEX

Genetics of Frontotemporal Dementia

(2016) Diana A. Olszewska et al.   Current Neurology and Neuroscience Reports

Mutant SOD1 mediated pathogenesis of Amyotrophic Lateral Sclerosis

(2016) Simran J. Kaur et al.   GENE

Proteomics: Technologies and Their Applications

(2016) Bilal Aslam et al.   JOURNAL OF CHROMATOGRAPHIC SCIENCE

Molecular neuropathology of frontotemporal dementia: insights into disease mechanisms from postmortem studies

(2016) Ian R. A. Mackenzie et al.   JOURNAL OF NEUROCHEMISTRY

Cognitive-behavioral screening reveals prevalent impairment in a large multicenter ALS cohort

(2016) Jennifer Murphy et al.   NEUROLOGY

Proteomic analysis of cerebrospinal fluid in amyotrophic lateral sclerosis

(2016) YAN CHEN et al.   Experimental and Therapeutic Medicine

Proteomic profiling of the spinal cord in ALS: decreased ATP5D levels suggest synaptic dysfunction in ALS pathogenesis

(2016) Jooyeon Engelen-Lee et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Susceptibility of Mutant SOD1 to Form a Destabilized Monomer Predicts Cellular Aggregation and Toxicity but Not In vitro Aggregation Propensity

(2016) Luke McAlary et al.   Frontiers in Neuroscience

Pathogenesis of FUS-associated ALS and FTD: insights from rodent models

(2016) Matthew Nolan et al.   Acta Neuropathologica Communications

Aberrant association of misfolded SOD1 with Na+/K+ATPase-α3 impairs its activity and contributes to motor neuron vulnerability in ALS

(2015) Céline Ruegsegger et al.   ACTA NEUROPATHOLOGICA

Structure, Dynamics, Assembly, and Evolution of Protein Complexes

(2015) Joseph A. Marsh et al.   Annual Review of Biochemistry

Label-Free LC–MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis

(2015) Mahlon A. Collins et al.   JOURNAL OF PROTEOME RESEARCH

Frontotemporal dementia

(2015) Jee Bang et al.   LANCET

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Review: An update on clinical, genetic and pathological aspects of frontotemporal lobar degenerations

(2015) Tammaryn Lashley et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Proteomic analyses reveal that loss of TDP-43 affects RNA processing and intracellular transport

(2015) M. Štalekar et al.   NEUROSCIENCE

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

Phenotypic Heterogeneity of Monogenic Frontotemporal Dementia

(2015) Alberto Benussi et al.   Frontiers in Aging Neuroscience

Criminal Behavior in Frontotemporal Dementia and Alzheimer Disease

(2015) Madeleine Liljegren et al.   JAMA Neurology

Bioinformatic analysis of proteomics data

(2014) Andreas Schmidt et al.   BMC Systems Biology

New criteria for frontotemporal dementia syndromes: clinical and pathological diagnostic implications

(2014) L. Chare et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Multicentre quality control evaluation of different biomarker candidates for amyotrophic lateral sclerosis

(2014) Stefan Lehnert et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

Blood Biomarkers for Amyotrophic Lateral Sclerosis: Myth or Reality?

(2014) Laura Robelin et al.   Biomed Research International

Protein aggregation in amyotrophic lateral sclerosis

(2013) Anna M. Blokhuis et al.   ACTA NEUROPATHOLOGICA

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

The behavioral variant of frontotemporal dementia: linking neuropathology to social cognition

(2013) Chiara Cerami et al.   NEUROLOGICAL SCIENCES

Proteomic Analysis Reveals Differentially Regulated Protein Acetylation in Human Amyotrophic Lateral Sclerosis Spinal Cord

(2013) Dong Liu et al.   PLoS One

The genetics and neuropathology of frontotemporal lobar degeneration

(2012) Anne Sieben et al.   ACTA NEUROPATHOLOGICA

Characterization of frontotemporal dementia and/or amyotrophic lateral sclerosis associated with the GGGGCC repeat expansion in C9ORF72

(2012) Bradley F. Boeve et al.   BRAIN

Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS

(2012) Oleg Butovsky et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebrospinal fluid amyloid-β 2-42 is decreased in Alzheimer’s, but not in frontotemporal dementia

(2012) Mirko Bibl et al.   JOURNAL OF NEURAL TRANSMISSION

Uric acid levels predict survival in men with amyotrophic lateral sclerosis

(2012) Sabrina Paganoni et al.   JOURNAL OF NEUROLOGY

Pharmaceutical and biomedical applications of affinity chromatography: Recent trends and developments

(2012) David S. Hage et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Neuroproteomics: an insight into ALS

(2012) D M F Mendonça et al.   NEUROLOGICAL RESEARCH

Monitoring CSF Proteome Alterations in Amyotrophic Lateral Sclerosis: Obstacles and Perspectives in Translating a Novel Marker Panel to the Clinic

(2012) Nils von Neuhoff et al.   PLoS One

pNfH is a promising biomarker for ALS

(2012) Jeban Ganesalingam et al.   Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

A harmonized classification system for FTLD-TDP pathology

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Pathological Stealing in Dementia

(2011) Mario F. Mendez   JOURNAL OF CLINICAL PSYCHIATRY

Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration

(2011) Yair M Gozal et al.   Molecular Neurodegeneration

A century of mass spectrometry: from atoms to proteomes

(2011) John R Yates III   NATURE METHODS

Post-translational modifications of tau protein: Implications for Alzheimer's disease

(2011) Ludovic Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Classification of primary progressive aphasia and its variants

(2011) M. L. Gorno-Tempini et al.   NEUROLOGY

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Proteomic Analysis of Hippocampal Dentate Granule Cells in Frontotemporal Lobar Degeneration: Application of Laser Capture Technology

(2011) Yair M. Gozal et al.   Frontiers in Neurology

The GRADE approach and Bradford Hill's criteria for causation

(2010) H. Schunemann et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

Proteomics of human cerebrospinal fluid: Discovery and verification of biomarker candidates in neurodegenerative diseases using quantitative proteomics

(2010) A.C. Kroksveen et al.   Journal of Proteomics

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY

Plasma biomarkers associated with ALS and their relationship to iron homeostasis

(2010) Ryan M. Mitchell et al.   MUSCLE & NERVE

Apathy Symptom Profile and Behavioral Associations in Frontotemporal Dementia vs Dementia of Alzheimer Type

(2009) Tiffany W. Chow et al.   ARCHIVES OF NEUROLOGY

Increased levels of inflammatory chemokines in amyotrophic lateral sclerosis

(2009) J. Kuhle et al.   EUROPEAN JOURNAL OF NEUROLOGY

The evolution of evidence hierarchies: what can Bradford Hill's ‘guidelines for causation’ contribute?

(2009) Jeremy Howick et al.   JOURNAL OF THE ROYAL SOCIETY OF MEDICINE

Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS)

(2009) Johannes Brettschneider et al.   NEUROSCIENCE LETTERS

Protein biomarkers for amyotrophic lateral sclerosis

(2008) Henrik Ryberg et al.   Expert Review of Proteomics

Biomarkers in amyotrophic lateral sclerosis

(2008) Martin R Turner et al.   LANCET NEUROLOGY

Proteome Analysis of Cerebrospinal Fluid in Amyotrophic Lateral Sclerosis (ALS)

(2008) Johannes Brettschneider et al.   NEUROCHEMICAL RESEARCH

A CSF biomarker panel for identification of patients with amyotrophic lateral sclerosis

(2008) R. M. Mitchell et al.   NEUROLOGY

Differential expression of ceruloplasmin isoforms in the cerebrospinal fluid of amyotrophic lateral sclerosis patients

(2008) Antonio Conti et al.   Proteomics Clinical Applications