Article
Engineering, Biomedical
Xinran Song, Yuxin Jiang, Weixing Zhang, Gomaa Elfawal, Kaili Wang, Di Jiang, Huoyan Hong, Jinglei Wu, Chuanglong He, Xiumei Mo, Hongsheng Wang
Summary: Transcutaneous immunization (TCI) is a safe, efficient, non-invasive, and convenient method. In this study, a transcutaneous tumor vaccine (TTV) delivery system was developed, which effectively inhibited the growth of melanoma by targeting dendritic cells (DCs) and using antigen and adjuvant. Combined application with anti-programmed death-1 monoclonal antibody (aPD-1) produced a synergistic antitumor effect.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Oncology
Yangbo Xu, Yafei Li, Xiaofan Chen, Feifan Xiang, Yong Deng, Zhong Li, Daiqing Wei
Summary: The study showed that TGF-beta reduced SDH expression by decreasing the transcription factor STAT1, leading to the upregulation of HIF1 alpha, altering glucose metabolism, and exacerbating chemoresistance in osteosarcoma cells. This connection between tumor cell metabolism and chemotherapy resistance may provide insights for developing additional treatments for osteosarcoma.
Article
Chemistry, Applied
Bi-Yuan Zheng, Song-Zi Li, Bing-De Zheng, Jia-Wen Ying, Qing-Yan Hu, Xiao-Hui Peng, Xingshu Li, Mei-Rong Ke, Jian-Dong Huang
Summary: Combining PDT caused by different-charged ZnPcs with anti-PD-L1 antibody has shown significant antitumor effects, with the cationic compound 2 exhibiting the highest synergistic antitumor effect with ICB and resulting in the most significant increase of CD8(+) T cells. This study suggests that mono-cationic ZnPc 2 is a highly promising photosensitizer specifically for PDT combined with immunotherapy, efficiently inhibiting tumor recurrence.
Article
Cell & Tissue Engineering
Jue Zhang, Sarah Webster, Bret Duffin, Matthew N. Bernstein, John Steill, Scott Swanson, Matthew H. Forsberg, Jennifer Bolin, Matthew E. Brown, Aditi Majumder, Christian M. Capitini, Ron Stewart, James A. Thomson, Igor I. Slukvin
Summary: In this study, anti-GD2 CAR was integrated into the AAVS1 locus of human pluripotent stem cells using CRISPR-Cas9 gene editing. A serum- and feeder-free differentiation protocol was established to generate CAR macrophages (CAR-Ms) through arterial endothelial-to-hematopoietic transition (EHT). The CAR-Ms produced using this method showed potent cytotoxic activity against GD2-expressing neuroblastoma and melanoma in vitro and neuroblastoma in vivo. This study provides a new platform for efficient generation of off-the-shelf CAR-Ms for antitumor immunotherapy.
Article
Multidisciplinary Sciences
Ting Yu, Yingxian Shi, Xinyan Pan, Qiang Feng, Peng Wang, Shuling Song, Lilin Yang, Julun Yang
Summary: In this study, the cell membrane penetrating peptide BR2 was used to deliver a broad-spectrum anti-p21Ras scFv gene into ganglioside expressing tumor cells. The fusion protein BR2-p21Ras scFv was found to specifically penetrate into tumor cells and bind with p21Ras, resulting in significant inhibition of tumor cell proliferation, migration, and colony formation, as well as promotion of apoptosis. This study suggests that BR2-p21Ras scFv has potential as a therapeutic antibody for ras-driven tumors.
Review
Immunology
Ming Yi, Tianye Li, Mengke Niu, Yuze Wu, Zhenyu Zhao, Kongming Wu
Summary: TGF-beta signaling has predictive value in cancer immunotherapy, and targeted therapies against TGF-beta are important strategies to overcome treatment resistance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yinda Qiu, Hao Yan, Ruiling Zheng, Xiaojing Chen, Yi Wang, Qi Yan, Yanfei Ye, Jianxia Zhang, Haoyi Han, Kun Wang, Yunjie Zhao, Lehao Huang, Xiaokun Li, Zhiguo Liu
Summary: The study demonstrated that cyy260 has an anti-tumor effect in osteosarcoma by suppressing PDGFR-beta and its downstream pathway, inhibiting cell proliferation, promoting apoptosis, and inhibiting tumor migration. Cyy260 also suppressed tumor cell growth in vivo and exhibited low toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Cell Biology
Susanne Krammer, Zuqin Yang, Hannah Mitlaender, Janina C. Grund, Sonja Trump, Susanne Mittler, Sabine Zirlik, Susetta Finotto
Summary: This study found that asthmatic patients had increased expression of TGF-beta RII in peripheral blood mononuclear cells and a suppressed release of TGF-beta after rhinovirus infection. Rhinovirus infection also activated Treg and NK cells.
Article
Orthopedics
Hongyu Zhang, Yuemei Huang, Qiuting Wen, Yan Li, Lin Guo, Na Ge
Summary: This study found that INHBA silencing plays a crucial role in osteosarcoma through TGF-beta 1-regulated proliferation, migration, and invasion.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Jinghong Yuan, Jingyu Jia, Tianlong Wu, Zhi Du, Qi Chen, Jian Zhang, Zhiwen Wu, Zhao Yuan, Xiaokun Zhao, Jiahao Liu, Jia Guo, Xigao Cheng
Summary: In this study, the potential mechanisms and function of DIO3OS as a lincRNA in osteosarcoma were investigated. It was found that DIO3OS can serve as a potential diagnostic and prognostic biomarker for osteosarcoma. Furthermore, DIO3OS was shown to have potential as an immunotherapeutic target through the TGF-beta signaling pathway.
CANCER CELL INTERNATIONAL
(2023)
Article
Oncology
Wei Zhang, Seong-Min Lim, Juyoung Hwang, Srinivasan Ramalingam, Myunghee Kim, Jun-O Jin
Summary: MPLA enhances anti-cancer immunity mediated by anti-PD-L1 antibodies by activating pDCs and increasing IFN-α production.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Adnan Deronic, Anneli Nilsson, Mia Thagesson, Doreen Werchau, Karin Enell Smith, Peter Ellmark
Summary: Mitazalimab, a human anti-CD40 agonist antibody, was found to activate antigen-presenting cells, leading to expansion and activation of antigen-specific T cells, ultimately enhancing the anti-tumor efficacy of a model cancer vaccine.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Yusuke Tamura, Masato Morikawa, Ryo Tanabe, Kohei Miyazono, Daizo Koinuma
Summary: The development of innovative therapeutic modalities for triple negative breast cancer is crucial. Recent research suggests that activation of RIG-I-like receptors in cancer cells can suppress tumor progression. Transfection of polyI:C, a synthetic dsRNA analogue, has shown promise in clinical trials, especially in inhibiting the TGF-beta signaling pathway to promote cancer cell death.
MOLECULAR ONCOLOGY
(2021)