Latarcins: versatile spider venom peptides

Detergent-Type Membrane Fragmentation by MSI-78, MSI-367, MSI-594, and MSI-843 Antimicrobial Peptides and Inhibition by Cholesterol: A Solid-State Nuclear Magnetic Resonance Study

(2015) Dong-Kuk Lee et al.   BIOCHEMISTRY

Action of the multifunctional peptide BP100 on native biomembranes examined by solid-state NMR

(2015) Julia Misiewicz et al.   JOURNAL OF BIOMOLECULAR NMR

Shifting gear in antimicrobial and anticancer peptides biophysical studies: from vesicles to cells

(2015) João M. Freire et al.   JOURNAL OF PEPTIDE SCIENCE

Cobra cytotoxins: determinants of antibacterial activity

(2015) Peter V. Dubovskii et al.   MENDELEEV COMMUNICATIONS

pHLIP-FIRE, a Cell Insertion-Triggered Fluorescent Probe for Imaging Tumors Demonstrates Targeted Cargo Delivery In Vivo

(2014) Alexander G. Karabadzhak et al.   ACS Chemical Biology

Resurrecting Inactive Antimicrobial Peptides from the Lipopolysaccharide Trap

(2014) Harini Mohanram et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Interaction of linear cationic peptides with phospholipid membranes and polymers of sialic acid

(2014) A. S. Kuznetsov et al.   BIOCHEMISTRY-MOSCOW

High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments

(2014) Guangshun Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Linear antimicrobial peptides from Ectatomma quadridens ant venom

(2014) Kirill A. Pluzhnikov et al.   BIOCHIMIE

Spectroscopic investigations of the binding mechanisms between antimicrobial peptides and membrane models of Pseudomonas aeruginosa and Klebsiella pneumoniae

(2014) Hanbo Chai et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peptide-based cancer therapy: Opportunity and challenge

(2014) Dongdong Wu et al.   CANCER LETTERS

Rational Design of Alpha-Helical Antimicrobial Peptides: Do's and Don'ts

(2014) Lars Erik Uggerhøj et al.   CHEMBIOCHEM

Structure-Function Relationship of Val/Arg-rich Peptides: Effects of Net Charge and Pro on Activity

(2014) Qingquan Ma et al.   Chemical Biology & Drug Design

Genes and evolution of two-domain toxins from lynx spider venom

(2014) Maria Y. Sachkova et al.   FEBS LETTERS

Effect of Divalent Cation Removal on the Structure of Gram-Negative Bacterial Outer Membrane Models

(2014) Luke A. Clifton et al.   LANGMUIR

Multitasking antimicrobial peptides in plant development and host defense against biotic/abiotic stress

(2014) Ravinder K. Goyal et al.   PLANT SCIENCE

Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer

(2014) N. T. Viola-Villegas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent advances in the understanding of brown spider venoms: From the biology of spiders to the molecular mechanisms of toxins

(2014) Luiza Helena Gremski et al.   TOXICON

Quo Vadis Venomics? A Roadmap to Neglected Venomous Invertebrates

(2014) Bjoern von Reumont et al.   Toxins

Panurgines, novel antimicrobial peptides from the venom of communal bee Panurgus calcaratus (Hymenoptera: Andrenidae)

(2013) Sabína Čujová et al.   AMINO ACIDS

Inhibitory activity and mechanism of two scorpion venom peptides against herpes simplex virus type 1

(2013) Wei Hong et al.   ANTIVIRAL RESEARCH

Two peptides, TsAP-1 and TsAP-2, from the venom of the Brazilian yellow scorpion, Tityus serrulatus: Evaluation of their antimicrobial and anticancer activities

(2013) Xiaoxiao Guo et al.   BIOCHIMIE

Peptide design for antimicrobial and immunomodulatory applications

(2013) Evan F. Haney et al.   BIOPOLYMERS

Toward the de novo design of antimicrobial peptides: Lack of correlation between peptide permeabilization of lipid vesicles and antimicrobial, cytolytic, or cytotoxic activity in living cells

(2013) Jing He et al.   BIOPOLYMERS

Cobra Cardiotoxins: Membrane Interactions and Pharmacological Potential

(2013) P. Dubovskii et al.   CURRENT MEDICINAL CHEMISTRY

Studies on Anticancer Activities of Lactoferrin and Lactoferricin

(2013) Cui Yin et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Spider toxins comprising disulfide-rich and linear amphipathic domains: a new class of molecules identified in the lynx spiderOxyopes takobius

(2013) Alexander A. Vassilevski et al.   FEBS Journal

Pharmacology of polymyxins: new insights into an ‘old’ class of antibiotics

(2013) Tony Velkov et al.   Future Microbiology

Structural Characterization of de Novo Designed L5K5W Model Peptide Isomers with Potent Antimicrobial and Varied Hemolytic Activities

(2013) Seo-Jin Kim et al.   MOLECULES

Toxin delivery by the coat protein of an aphid-vectored plant virus provides plant resistance to aphids

(2013) Bryony C Bonning et al.   NATURE BIOTECHNOLOGY

Family of pH (low) insertion peptides for tumor targeting

(2013) D. Weerakkody et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From antimicrobial to anticancer peptides. A review

(2013) Diana Gaspar et al.   Frontiers in Microbiology

Importance of the Cell Membrane on the Mechanism of Action of Cyclotides

(2012) Sónia Troeira Henriques et al.   ACS Chemical Biology

Spider-Venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests

(2012) Glenn F. King et al.   Annual Review of Entomology

Antimicrobial peptide from spider venom inhibits Chlamydia trachomatis infection at an early stage

(2012) Vassili N. Lazarev et al.   ARCHIVES OF MICROBIOLOGY

Imaging the membrane lytic activity of bioactive peptide latarcin 2a

(2012) Amy Won et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cysteine-rich toxins from Lachesana tarabaevi spider venom with amphiphilic C-terminal segments

(2012) Alexey I. Kuzmenkov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Electrical potentiation of the membrane permeabilization by new peptides with anticancer properties

(2012) Victor V. Lemeshko   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Reduction of Helical Content by Insertion of a Disulfide Bond Leads to an Antimicrobial Peptide with Decreased Hemolytic Activity

(2012) Heeyong Hwang et al.   ChemMedChem

A Novel Spider Peptide Toxin Suppresses Tumor Growth Through Dual Signaling Pathways

(2012) Z. Liu et al.   CURRENT MOLECULAR MEDICINE

Structure and Dynamics of Cardiotoxins

(2012) Anastasia G. Konshina et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Unusual titration of the membrane-bound artificial hemagglutinin fusion peptide

(2012) Peter V. Dubovskii   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Multicomponent venom of the spider Cupiennius salei: a bioanalytical investigation applying different strategies

(2012) Christian Trachsel et al.   FEBS Journal

A Venom-derived Neurotoxin, CsTx-1, from the SpiderCupiennius saleiExhibits Cytolytic Activities

(2012) Lucia Kuhn-Nentwig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

“It stings a bit but it cleans well”: Venoms of Hymenoptera and their antimicrobial potential

(2012) Sébastien J.M. Moreau   JOURNAL OF INSECT PHYSIOLOGY

Identification and characterization of a novel antimicrobial peptide from the venom of the ant Tetramorium bicarinatum

(2012) Aline Rifflet et al.   PEPTIDES

Anti-HIV-1 Activity of a New Scorpion Venom Peptide Derivative Kn2-7

(2012) Yaoqing Chen et al.   PLoS One

pHLIP peptide targets nanogold particles to tumors

(2012) L. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of lipids in the interaction of antimicrobial peptides with membranes

(2012) Vitor Teixeira et al.   PROGRESS IN LIPID RESEARCH

cDNA cloning and characterization of the antibacterial peptide cecropin 1 from the diamondback moth, Plutella xylostella L

(2012) Fengliang Jin et al.   PROTEIN EXPRESSION AND PURIFICATION

Cardiotoxin III suppresses MDA-MB-231 cell metastasis through the inhibition of EGF/EGFR-mediated signaling pathway

(2012) Pei-Chien Tsai et al.   TOXICON

Complex cocktails: the evolutionary novelty of venoms

(2012) Nicholas R. Casewell et al.   TRENDS IN ECOLOGY & EVOLUTION

Host-Defense Activities of Cyclotides

(2012) David J. Craik   Toxins

Emerging Themes and Therapeutic Prospects for Anti-Infective Peptides

(2011) Nannette Y. Yount et al.   Annual Review of Pharmacology and Toxicology

Spider Venom Peptides for Gene Therapy of Chlamydia Infection

(2011) Vassili N. Lazarev et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Solution structure of a defense peptide from wheat with a 10-cysteine motif

(2011) Peter V. Dubovskii et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bee venom in cancer therapy

(2011) Nada Oršolić   CANCER AND METASTASIS REVIEWS

Membrane-active host defense peptides – Challenges and perspectives for the development of novel anticancer drugs

(2011) Sabrina Riedl et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Investigating the effect of a single glycine to alanine substitution on interactions of antimicrobial peptide latarcin 2a with a lipid membrane

(2011) Grace Idiong et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Venoms as a platform for human drugs: translating toxins into therapeutics

(2011) Glenn F King   EXPERT OPINION ON BIOLOGICAL THERAPY

Novel lynx spider toxin shares common molecular architecture with defense peptides from frog skin

(2011) Peter V. Dubovskii et al.   FEBS Journal

Potent antimicrobial peptides with selectivity for Bacillus anthracis over human erythrocytes

(2011) Raymond M. Dawson et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial Peptides: Successes, Challenges and Unanswered Questions

(2011) William C. Wimley et al.   JOURNAL OF MEMBRANE BIOLOGY

Effect of Point Mutations on the Secondary Structure and Membrane Interaction of Antimicrobial Peptide Anoplin

(2011) Amy Won et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Structural and biological characterization of mastoparans in the venom of Vespa species in Taiwan

(2011) Chun-Hsien Lin et al.   PEPTIDES

Chemical and biological characterization of four new linear cationic α-helical peptides from the venoms of two solitary eumenine wasps

(2011) Marisa Rangel et al.   TOXICON

Arthropod venoms and cancer

(2011) Tiago Elias Heinen et al.   TOXICON

Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells

(2010) Lucia Kuhn-Nentwig et al.   AMINO ACIDS

Identification of Novel Human Immunodeficiency Virus Type 1-Inhibitory Peptides Based on the Antimicrobial Peptide Database

(2010) G. Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Probing the “Charge Cluster Mechanism” in Amphipathic Helical Cationic Antimicrobial Peptides

(2010) Raquel F. Epand et al.   BIOCHEMISTRY

A Thermodynamic Approach to the Mechanism of Cell-Penetrating Peptides in Model Membranes

(2010) Alesia N. McKeown et al.   BIOCHEMISTRY

Molecular diversity of spider venom

(2010) A. A. Vassilevski et al.   BIOCHEMISTRY-MOSCOW

Investigating the effects of L- to D-amino acid substitution and deamidation on the activity and membrane interactions of antimicrobial peptide anoplin

(2010) Amy Won et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The importance of bacterial membrane composition in the structure and function of aurein 2.2 and selected variants

(2010) John T.J. Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Haemolytic and cytotoxic action of latarcin Ltc2a

(2010) Olga V. Vorontsova et al.   BIOCHIMIE

Use of Venom Peptides to Probe Ion Channel Structure and Function

(2010) Sébastien Dutertre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antimicrobial Peptides Induce Growth of Phosphatidylglycerol Domains in a Model Bacterial Membrane

(2010) Anton A. Polyansky et al.   Journal of Physical Chemistry Letters

Structure, Interactions, and Antibacterial Activities of MSI-594 Derived Mutant Peptide MSI-594F5A in Lipopolysaccharide Micelles: Role of the Helical Hairpin Conformation in Outer-Membrane Permeabilization

(2010) Prerna N Domadia et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ArachnoServer 2.0, an updated online resource for spider toxin sequences and structures

(2010) V. Herzig et al.   NUCLEIC ACIDS RESEARCH

Structure of an analog of fusion peptide from hemagglutinin

(2010) Peter V. Dubovskii et al.   PROTEIN SCIENCE

Spider-Venom Peptides as Therapeutics

(2010) Natalie J. Saez et al.   Toxins

LyeTx I, a potent antimicrobial peptide from the venom of the spider Lycosa erythrognatha

(2009) D. M. Santos et al.   AMINO ACIDS

The Toxicogenomic Multiverse: Convergent Recruitment of Proteins Into Animal Venoms

(2009) Bryan G. Fry et al.   Annual Review of Genomics and Human Genetics

Potential-dependent membrane permeabilization and mitochondrial aggregation caused by anticancer polyarginine-KLA peptides

(2009) Victor V. Lemeshko   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structure-Dependent Charge Density as a Determinant of Antimicrobial Activity of Peptide Analogues of Defensin

(2009) Yang Bai et al.   BIOCHEMISTRY

Mechanisms of Antimicrobial, Cytolytic, and Cell-Penetrating Peptides: From Kinetics to Thermodynamics

(2009) Paulo F. Almeida et al.   BIOCHEMISTRY

PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes

(2009) Timothy V. Pyrkov et al.   BIOINFORMATICS

Antibacterial-Resistant Pseudomonas aeruginosa: Clinical Impact and Complex Regulation of Chromosomally Encoded Resistance Mechanisms

(2009) P. D. Lister et al.   CLINICAL MICROBIOLOGY REVIEWS

Cationic amphiphilic peptides with cancer-selective toxicity

(2009) Frank Schweizer   EUROPEAN JOURNAL OF PHARMACOLOGY

Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides

(2009) Surajit Bhattacharjya et al.   FEBS Journal

N-terminal amphipathic helix as a trigger of hemolytic activity in antimicrobial peptides: A case study in latarcins

(2009) Anton A. Polyansky et al.   FEBS LETTERS

Structure−Activity Relationships of Polymyxin Antibiotics

(2009) Tony Velkov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Domains in bacterial membranes and the action of antimicrobial agents

(2009) Richard M. Epand et al.   Molecular BioSystems

The alyteserins: Two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae)

(2009) J. Michael Conlon et al.   PEPTIDES

MPEx: A tool for exploring membrane proteins

(2009) Craig Snider et al.   PROTEIN SCIENCE

Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom

(2008) Alexander A. Vassilevski et al.   BIOCHEMICAL JOURNAL

Three-Dimensional Structure/Hydrophobicity of Latarcins Specifies Their Mode of Membrane Activity†,‡

(2008) Peter V. Dubovskii et al.   BIOCHEMISTRY

Control of cell selectivity of antimicrobial peptides

(2008) Katsumi Matsuzaki   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitoparan and target-selective chimeric analogues: Membrane translocation and intracellular redistribution induces mitochondrial apoptosis

(2008) Sarah Jones et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pore Formation Induced by an Antimicrobial Peptide: Electrostatic Effects

(2008) Frantz Jean-François et al.   BIOPHYSICAL JOURNAL

Antimicrobial activity of neuropeptides against a range of micro-organisms from skin, oral, respiratory and gastrointestinal tract sites

(2008) Ikhlas A. El Karim et al.   JOURNAL OF NEUROIMMUNOLOGY

Bacterial Membranes as Predictors of Antimicrobial Potency

(2008) Richard M. Epand et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

APD2: the updated antimicrobial peptide database and its application in peptide design

(2008) Guangshun Wang et al.   NUCLEIC ACIDS RESEARCH

Identification and characterization of novel reptile cathelicidins from elapid snakes

(2008) Hui Zhao et al.   PEPTIDES

Identification of novel host defense peptides and the absence of α-defensins in the bovine genome

(2008) Christopher D. Fjell et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Studies on anticancer activities of antimicrobial peptides

(2007) David W. Hoskin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The impact of membrane lipid composition on antimicrobial function of an α-helical peptide

(2007) Sarah R. Dennison et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Identification, characterization and expression of cathelicidin in the pouch young of tammar wallaby (Macropus eugenii)

(2007) Kerry A. Daly et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY