Host-Defense Activities of Cyclotides

Discovery of Cyclotides in the Fabaceae Plant Family Provides New Insights into the Cyclization, Evolution, and Distribution of Circular Proteins

(2011) Aaron G. Poth et al.   ACS Chemical Biology

The Role of Conserved Glu Residue on Cyclotide Stability and Activity: A Structural and Functional Study of Kalata B12, a Naturally Occurring Glu to Asp Mutant

(2011) Conan K. L. Wang et al.   BIOCHEMISTRY

Discovery and Characterization of Novel Cyclotides Originated from Chimeric Precursors Consisting of Albumin-1 Chain a and Cyclotide Domains in the Fabaceae Family

(2011) Giang Kien Truc Nguyen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decoding the Membrane Activity of the Cyclotide Kalata B1

(2011) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of an unusual biosynthetic origin for circular proteins in legumes

(2011) A. G. Poth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and biochemical characteristics of the cyclotide kalata B5 from Oldenlandia affinis

(2010) Manuel R. Plan et al.   BIOPOLYMERS

Cyclotides, a promising molecular scaffold for peptide-based therapeutics

(2010) Krishnappa Jagadish et al.   BIOPOLYMERS

Evaluation of toxicity and antitumor activity of cycloviolacin O2 in mice

(2010) Robert Burman et al.   BIOPOLYMERS

The cyclotide cycloviolacin O2 from Viola odorata has potent bactericidal activity against Gram-negative bacteria

(2010) M. Pranting et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lysine-scanning Mutagenesis Reveals an Amendable Face of the Cyclotide Kalata B1 for the Optimization of Nematocidal Activity

(2010) Yen-Hua Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

“Splicing up” drug discovery.☆Cell-based expression and screening of genetically-encoded libraries of backbone-cyclized polypeptides

(2009) Harshkumar Sancheti et al.   ADVANCED DRUG DELIVERY REVIEWS

Discovery, structure and biological activities of cyclotides☆

(2009) Norelle L. Daly et al.   ADVANCED DRUG DELIVERY REVIEWS

In vivo biosynthesis of an Ala-scan library based on the cyclic peptide SFTI-1

(2009) Jeffrey Austin et al.   AMINO ACIDS

Despite a Conserved Cystine Knot Motif, Different Cyclotides Have Different Membrane Binding Modes

(2009) Conan K. Wang et al.   BIOPHYSICAL JOURNAL

Progress in kalata peptide production via plant cell bioprocessing

(2009) Heike Dörnenburg   Biotechnology Journal

Biosynthesis and Biological Screening of a Genetically Encoded Library Based on the Cyclotide MCoTI-I

(2009) Jeffrey Austin et al.   CHEMBIOCHEM

Combined X-ray and NMR Analysis of the Stability of the Cyclotide Cystine Knot Fold That Underpins Its Insecticidal Activity and Potential Use as a Drug Scaffold

(2009) Conan K. Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Biological Activity of the Prototypic Cyclotide Kalata B1 Is Modulated by the Formation of Multimeric Pores

(2009) Yen-Hua Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Potent Inhibitors of β-Tryptase and Human Leukocyte Elastase Based on the MCoTI-II Scaffold

(2009) Panumart Thongyoo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Circling the enemy: cyclic proteins in plant defence

(2009) David J. Craik   TRENDS IN PLANT SCIENCE

Anthelmintic activity of cyclotides: In vitro studies with canine and human hookworms

(2008) Michelle L. Colgrave et al.   ACTA TROPICA

Dissecting the Oxidative Folding of Circular Cystine Knot Miniproteins

(2008) Sunithi Gunasekera et al.   ANTIOXIDANTS & REDOX SIGNALING

Cyclotides: Natural, Circular Plant Peptides that Possess Significant Activity against Gastrointestinal Nematode Parasites of Sheep†

(2008) Michelle L. Colgrave et al.   BIOCHEMISTRY

Plant cell culture technology–harnessing a biological approach for competitive cyclotides production

(2008) Heike Dörnenburg   BIOTECHNOLOGY LETTERS

The Anthelmintic Activity of the Cyclotides: Natural Variants with Enhanced Activity

(2008) Michelle L. Colgrave et al.   CHEMBIOCHEM

Total chemical synthesis of proteins

(2008) Stephen B. H. Kent   CHEMICAL SOCIETY REVIEWS

Cyclic Peptides fromOldenlandia affinisDC. Molecular and Biological Properties

(2008) Lorents Gran et al.   CHEMISTRY & BIODIVERSITY

Backbone Cyclised Peptides from Plants Show Molluscicidal Activity against the Rice PestPomacea canaliculata(Golden Apple Snail)

(2008) Manuel Rey R. Plan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Alanine Scanning Mutagenesis of the Prototypic Cyclotide Reveals a Cluster of Residues Essential for Bioactivity

(2008) Shane M. Simonsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plant cell-based processes for cyclotides production

(2008) Heike Dörnenburg et al.   JOURNAL OF BIOTECHNOLOGY

Divalent cation coordination and mode of membrane interaction in cyclotides: NMR spatial structure of ternary complex Kalata B7/Mn2+/DPC micelle

(2008) Zakhar O. Shenkarev et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Chemical and biomimetic total syntheses of natural and engineered MCoTI cyclotides

(2008) Panumart Thongyoo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Distribution and Evolution of Circular Miniproteins in Flowering Plants

(2008) C. W. Gruber et al.   PLANT CELL

Plant cyclotides disrupt epithelial cells in the midgut of lepidopteran larvae

(2008) B. L. Barbeta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultra-Stable Peptide Scaffolds for Protein Engineering—Synthesis and Folding of the Circular Cystine Knotted Cyclotide Cycloviolacin O2

(2007) Teshome Leta Aboye et al.   CHEMBIOCHEM

Anti-HIV Cyclotides from the Chinese Medicinal HerbViola yedoensis

(2007) Conan K. L. Wang et al.   JOURNAL OF NATURAL PRODUCTS