Suppression of lusitropy as a disease mechanism in cardiomyopathies

Left ventricular contractile reserve as a determinant of adverse clinical outcomes: a systematic review

(2022) Paul M. Thein et al.   INTERNAL MEDICINE JOURNAL

Epigallocatechin-3-gallate exerts cardioprotective effects related to energy metabolism in pressure overload-induced cardiac dysfunction

(2022) Qiuhong Mou et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Recent studies of the molecular mechanism of lusitropy due to phosphorylation of cardiac troponin I by protein kinase A

(2022) Steven Marston   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Dilated Cardiomyopathy Mutations and Phosphorylation disrupt the Active Orientation of Cardiac Troponin C

(2021) Zabed Mahmud et al.   JOURNAL OF MOLECULAR BIOLOGY

Meta-analysis of cardiomyopathy-associated variants in troponin genes identifies loci and intragenic hot spots that are associated with worse clinical outcomes

(2020) Hanna J. Tadros et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Small Molecules Acting on Myofilaments as Treatments for Heart and Skeletal Muscle Diseases

(2020) Khulud Alsulami et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functional and transcriptomic insights into pathogenesis of R9C phospholamban mutation using human induced pluripotent stem cell-derived cardiomyocytes

(2018) Delaine K. Ceholski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Molecular Defects in Cardiac Myofilament Ca2+-Regulation Due to Cardiomyopathy-Linked Mutations Can Be Reversed by Small Molecules Binding to Troponin

(2018) Alice Sheehan et al.   Frontiers in Physiology

Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations

(2017) Charles M. Stevens et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structural basis of alpha-tropomyosin linked (Asp230Asn) familial dilated cardiomyopathy

(2017) M.L. Lynn et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Abnormal contractility in human heart myofibrils from patients with dilated cardiomyopathy due to mutations in TTN and contractile protein genes

(2017) Petr G. Vikhorev et al.   Scientific Reports

Mutations in troponin T associated with Hypertrophic Cardiomyopathy increase Ca2+-sensitivity and suppress the modulation of Ca2+-sensitivity by troponin I phosphorylation

(2016) Andrew E. Messer et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function inMybpc3-targeted HCM mouse model

(2016) Aref Najafi et al.   CARDIOVASCULAR RESEARCH

Reassessment of Mendelian gene pathogenicity using 7,855 cardiomyopathy cases and 60,706 reference samples

(2016) Roddy Walsh et al.   GENETICS IN MEDICINE

Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres

(2016) Alexey V. Dvornikov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Cardiac Troponin I Mutation P83S on Contractile Properties and the Modulation by PKA-Mediated Phosphorylation

(2016) Yuanhua Cheng et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Mutation analysis of the phospholamban gene in 315 South Africans with dilated, hypertrophic, peripartum and arrhythmogenic right ventricular cardiomyopathies

(2016) Maryam Fish et al.   Scientific Reports

Why Is there a Limit to the Changes in Myofilament Ca2+-Sensitivity Associated with Myopathy Causing Mutations?

(2016) Steven B. Marston   Frontiers in Physiology

A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress

(2015) Ross Wilkinson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Uncoupling of myofilament Ca2+sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate

(2015) Maria Papadaki et al.   CARDIOVASCULAR RESEARCH

Acute Inotropic and Lusitropic Effects of Cardiomyopathic R9C Mutation of Phospholamban

(2015) Neha Abrol et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

(2015) Yuanhua Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dissecting human skeletal muscle troponin proteoforms by top-down mass spectrometry

(2015) Yi-Chen Chen et al.   JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY

Hypertrophic and Dilated Cardiomyopathy: Four Decades of Basic Research on Muscle Lead to Potential Therapeutic Approaches to These Devastating Genetic Diseases

(2014) James A. Spudich   BIOPHYSICAL JOURNAL

The Dilated Cardiomyopathy-Causing Mutation ACTC E361G in Cardiac Muscle Myofibrils Specifically Abolishes Modulation of Ca 2+ Regulation by Phosphorylation of Troponin I

(2014) Petr G. Vikhorev et al.   BIOPHYSICAL JOURNAL

Desensitization of Myofilaments to Ca2+ as a Therapeutic Target for Hypertrophic Cardiomyopathy With Mutations in Thin Filament Proteins

(2014) M. L. Alves et al.   Circulation-Cardiovascular Genetics

Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy

(2014) David Dweck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of cardiomyopathy

(2014) Andrew E. Messer et al.   Frontiers in Physiology

Familial dilated cardiomyopathy mutations uncouple troponin I phosphorylation from changes in myofibrillar Ca2+ sensitivity

(2013) Massimiliano Memo et al.   CARDIOVASCULAR RESEARCH

Regulation of Cardiac L-Type Ca 2+ Channel Ca V 1.2 Via the β-Adrenergic-cAMP-Protein Kinase A Pathway

(2013) Sharon Weiss et al.   CIRCULATION RESEARCH

HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice

(2013) Rachel K. Moore et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Depressed Frank–Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210

(2013) Takahiro Inoue et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice

(2013) Andrea Stöhr et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*

(2013) Alison Y. Li et al.   PLoS One

Mutations in thin Filament Proteins that Cause Familial Dilated Cardiomyopathy Uncouple Troponin I Phosphorylation from Changes in Myofibrillar Ca2+-Sensitivity

(2012) Massimiliano Memo et al.   BIOPHYSICAL JOURNAL

DCM-Linked D230N Tropomyosin Mutation Results in Early Dilatation and Systolic Dysfunction in Mice

(2012) Lauren Tal et al.   BIOPHYSICAL JOURNAL

Myofibrillar Ca2+ sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T

(2012) Christopher R. Bayliss et al.   CARDIOVASCULAR RESEARCH

Myofilament Ca Sensitization Increases Cytosolic Ca Binding Affinity, Alters Intracellular Ca Homeostasis, and Causes Pause-Dependent Ca-Triggered Arrhythmia

(2012) Tilmann Schober et al.   CIRCULATION RESEARCH

The Rates of Ca2+Dissociation and Cross-bridge Detachment from Ventricular Myofibrils as Reported by a Fluorescent Cardiac Troponin C

(2012) Sean C. Little et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

(2012) Peter Michael Kekenes-Huskey et al.   PLoS Computational Biology

Mutations in the human phospholamban gene in patients with heart failure

(2011) Alessandra Medeiros et al.   AMERICAN HEART JOURNAL

The concept of ventricular reserve in heart failure and pulmonary hypertension: an old metric that brings us one step closer in our quest for prediction

(2011) Francois Haddad et al.   CURRENT OPINION IN CARDIOLOGY

Prognostic value of NT-pro BNP, left ventricular inotropic reserve and cardiopulmonary exercise test in patients with non-ischemic dilated cardiomyopathy

(2011) Fragiskos Parthenakis et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy

(2011) Yingcai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization ofTNNC1Rare Variants Identified in Dilated Cardiomyopathy

(2011) Jose Renato Pinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Augmented Phosphorylation of Cardiac Troponin I in Hypertensive Heart Failure

(2011) Xintong Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Mechanism of the E99K Mutation in Cardiac Actin (ACTCGene) That Causes Apical Hypertrophy in Man and Mouse

(2011) Weihua Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Do Mutations in Contractile Proteins Cause the Primary Familial Cardiomyopathies?

(2011) Steven B. Marston   Journal of Cardiovascular Translational Research

Biological actions of green tea catechins on cardiac troponin C

(2010) Naoto Tadano et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Common MLP (Muscle LIM Protein) Variant Is Associated With Cardiomyopathy

(2010) Ralph Knöll et al.   CIRCULATION RESEARCH

Investigation of a transgenic mouse model of familial dilated cardiomyopathy

(2010) Weihua Song et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Increased myofilament Ca2+-sensitivity and arrhythmia susceptibility

(2010) Sabine Huke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Identification and Functional Characterization of Cardiac Troponin I As a Novel Disease Gene in Autosomal Dominant Dilated Cardiomyopathy

(2009) Sebastian Carballo et al.   CIRCULATION RESEARCH

Functional Analysis of a Unique Troponin C Mutation, GLY159ASP, that Causes Familial Dilated Cardiomyopathy, Studied in Explanted Heart Muscle

(2009) Emma C. Dyer et al.   Circulation-Heart Failure

Prognostic significance of contractile reserve assessed by dobutamine-induced changes of Tei index in patients with idiopathic dilated cardiomyopathy

(2009) A. Vlahovic Stipac et al.   European Journal of Echocardiography

Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?

(2009) Ruth H. Willott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The changes of the cardiac structure and function in cTnTR141W transgenic mice

(2008) Feng Juan et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Functional effects of DCM mutation G159D in troponin C from an explanted heart

(2008) Emma Dyer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Unraveling Molecular Complexity of Phosphorylated Human Cardiac Troponin I by Top Down Electron Capture Dissociation/Electron Transfer Dissociation Mass Spectrometry

(2008) Vlad Zabrouskov et al.   MOLECULAR & CELLULAR PROTEOMICS

Modulation of Cardiac Troponin C Function by the Cardiac-Specific N-Terminus of Troponin I: Influence of PKA Phosphorylation and Involvement in Cardiomyopathies

(2007) Olga K. Baryshnikova et al.   JOURNAL OF MOLECULAR BIOLOGY