Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

Effects of HCM cTnI Mutation R145G on Troponin Structure and Modulation by PKA Phosphorylation Elucidated by Molecular Dynamics Simulations

(2015) Steffen Lindert et al.   BIOPHYSICAL JOURNAL

The R21C Mutation in Cardiac Troponin I Imposes Differences in Contractile Force Generation between the Left and Right Ventricles of Knock-In Mice

(2015) Jingsheng Liang et al.   Biomed Research International

Ca2+-regulatory function of the inhibitory peptide region of cardiac troponin I is aided by the C-terminus of cardiac troponin T: Effects of familial hypertrophic cardiomyopathy mutations cTnI R145G and cTnT R278C, alone and in combination, on filament sliding

(2014) Nicolas M. Brunet et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

PKA Phosphorylation of Cardiac Troponin I Modulates Activation and Relaxation Kinetics of Ventricular Myofibrils

(2014) Vijay Rao et al.   BIOPHYSICAL JOURNAL

Computational Studies of the Effect of the S23D/S24D Troponin I Mutation on Cardiac Troponin Structural Dynamics

(2014) Yuanhua Cheng et al.   BIOPHYSICAL JOURNAL

Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy

(2014) David Dweck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and functional consequences of cardiac troponin C L57Q and I61Q Ca2+-desensitizing variants

(2013) Dan Wang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural and kinetic effects of hypertrophic cardiomyopathy related mutations R146G/Q and R163W on the regulatory switching activity of rat cardiac troponin I

(2012) Zhiqun Zhou et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Structural and Functional Consequences of the Cardiac Troponin C L48Q Ca2+-Sensitizing Mutation

(2012) Dan Wang et al.   BIOCHEMISTRY

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle

(2012) Vijay S. Rao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Identifying Sarcomere Gene Mutations in Hypertrophic Cardiomyopathy

(2011) Christine E. Seidman et al.   CIRCULATION RESEARCH

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy

(2011) Yingcai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calcium binding kinetics of troponin C strongly modulate cooperative activation and tension kinetics in cardiac muscle

(2010) Kareen L. Kreutziger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Sites of Intra- and Intermolecular Cross-linking of the N-terminal Extension of Troponin I in Human Cardiac Whole Troponin Complex

(2009) Chad M. Warren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?

(2009) Ruth H. Willott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation

(2008) R. John Solaro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Kinase A–Mediated Phosphorylation of cMyBP-C Increases Proximity of Myosin Heads to Actin in Resting Myocardium

(2008) Brett A. Colson et al.   CIRCULATION RESEARCH

Functional Consequences of the Human Cardiac Troponin I Hypertrophic Cardiomyopathy Mutation R145G in Transgenic Mice

(2008) Yuhui Wen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thin filament Ca2+binding properties and regulatory unit interactions alter kinetics of tension development and relaxation in rabbit skeletal muscle

(2008) Kareen L. Kreutziger et al.   JOURNAL OF PHYSIOLOGY-LONDON

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes

(2008) Stephanie Reis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of the acidic N′ region of cardiac troponin I in regulating myocardial function

(2007) Sakthivel Sadayappan et al.   FASEB JOURNAL