Changes in the dynamics of the cardiac troponin C molecule explain the effects of Ca2+-sensitizing mutations

Allosteric Transmission along a Loosely Structured Backbone Allows a Cardiac Troponin C Mutant to Function with Only One Ca2+Ion

(2017) Mayra de A. Marques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced troponin I binding explains the functional changes produced by the hypertrophic cardiomyopathy mutation A8V of cardiac troponin C

(2016) Henry G. Zot et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Characterization of Zebrafish Cardiac and Slow Skeletal Troponin C Paralogs by MD Simulation and ITC

(2016) Charles M. Stevens et al.   BIOPHYSICAL JOURNAL

A Tension-Based Model Distinguishes Hypertrophic versus Dilated Cardiomyopathy

(2016) Jennifer Davis et al.   CELL

Functional Divergence in Teleost Cardiac Troponin Paralogs Guides Variation in the Interaction of TnI Switch Region with TnC

(2016) Christine E. Genge et al.   Genome Biology and Evolution

Molecular Effects of cTnC DCM Mutations on Calcium Sensitivity and Myofilament Activation—An Integrated Multiscale Modeling Study

(2016) Sukriti Dewan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

(2016) Vikram Shettigar et al.   Nature Communications

Effects of HCM cTnI Mutation R145G on Troponin Structure and Modulation by PKA Phosphorylation Elucidated by Molecular Dynamics Simulations

(2015) Steffen Lindert et al.   BIOPHYSICAL JOURNAL

Fluorescence Based Characterization of Calcium Sensitizer Action on the Troponin Complex

(2015) William Schlecht et al.   Chemical Biology & Drug Design

In Vivo Analysis of Troponin C Knock-In (A8V) MiceCLINICAL PERSPECTIVE

(2015) Adriano S. Martins et al.   Circulation-Cardiovascular Genetics

Structure and function of cardiac troponin C (TNNC1): Implications for heart failure, cardiomyopathies, and troponin modulating drugs

(2015) Monica X. Li et al.   GENE

The structural and functional effects of the familial hypertrophic cardiomyopathy-linked cardiac troponin C mutation, L29Q

(2015) Ian M. Robertson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Representation of Ion–Protein Interactions Using the Drude Polarizable Force-Field

(2015) Hui Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

New Perspectives on the Prevalence of Hypertrophic Cardiomyopathy

(2015) Christopher Semsarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

In Vivo Analysis of Troponin C Knock-In (A8V) MiceCLINICAL PERSPECTIVE

(2015) Adriano S. Martins et al.   Circulation-Cardiovascular Genetics

In Vitro and in Situ Structure and Function of the Cardiac Troponin C Familial Hypertrophic Cardiomyopathy-Linked Mutation, L29Q

(2015) Ian M. Robertson et al.   BIOPHYSICAL JOURNAL

g_mmpbsa—A GROMACS Tool for High-Throughput MM-PBSA Calculations

(2014) Rashmi Kumari et al.   Journal of Chemical Information and Modeling

Regulatory domain of troponin moves dynamically during activation of cardiac muscle

(2014) Ivanka Sevrieva et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Thin filament incorporation of an engineered cardiac troponin C variant (L48Q) enhances contractility in intact cardiomyocytes from healthy and infarcted hearts

(2014) Erik R. Feest et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C

(2014) Peter M. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca2+-sensitivity in the pathogenesis of cardiomyopathy

(2014) Andrew E. Messer et al.   Frontiers in Physiology

The structure of cardiac troponin C regulatory domain with bound Cd2+reveals a closed conformation and unique ion coordination

(2013) Xiaolu Linda Zhang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Effects of Calcium Binding and the Hypertrophic Cardiomyopathy A8V Mutation on the Dynamic Equilibrium between Closed and Open Conformations of the Regulatory N-Domain of Isolated Cardiac Troponin C

(2013) Nicole M. Cordina et al.   BIOCHEMISTRY

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

A flexible algorithm for calculating pair interactions on SIMD architectures

(2013) Szilárd Páll et al.   COMPUTER PHYSICS COMMUNICATIONS

Familial Hypertrophic Cardiomyopathy Related Cardiac Troponin C L29Q Mutation Alters Length-Dependent Activation and Functional Effects of Phosphomimetic Troponin I*

(2013) Alison Y. Li et al.   PLoS One

Structural and Functional Consequences of the Cardiac Troponin C L48Q Ca2+-Sensitizing Mutation

(2012) Dan Wang et al.   BIOCHEMISTRY

Long-Timescale Molecular Dynamics Simulations Elucidate the Dynamics and Kinetics of Exposure of the Hydrophobic Patch in Troponin C

(2012) Steffen Lindert et al.   BIOPHYSICAL JOURNAL

A Mutation inTNNC1-encoded Cardiac Troponin C, TNNC1-A31S, Predisposes to Hypertrophic Cardiomyopathy and Ventricular Fibrillation

(2012) Michelle S. Parvatiyar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thermodynamics and molecular dynamics simulations of calcium binding to the regulatory site of human cardiac troponin C: evidence for communication with the structural calcium binding sites

(2012) Rachel A. Skowronsky et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Dynamics and Calcium Association to the N-Terminal Regulatory Domain of Human Cardiac Troponin C: A Multiscale Computational Study

(2012) Steffen Lindert et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Molecular Basis of Calcium-Sensitizing and Desensitizing Mutations of the Human Cardiac Troponin C Regulatory Domain: A Multi-Scale Simulation Study

(2012) Peter Michael Kekenes-Huskey et al.   PLoS Computational Biology

Identifying Sarcomere Gene Mutations in Hypertrophic Cardiomyopathy

(2011) Christine E. Seidman et al.   CIRCULATION RESEARCH

Effect of Calcium-Sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems

(2010) Svetlana B. Tikunova et al.   BIOCHEMISTRY

Peripartum Cardiomyopathy as a Part of Familial Dilated Cardiomyopathy

(2010) Karin Y. van Spaendonck-Zwarts et al.   CIRCULATION

g_wham—A Free Weighted Histogram Analysis Implementation Including Robust Error and Autocorrelation Estimates

(2010) Jochen S. Hub et al.   Journal of Chemical Theory and Computation

Improved side-chain torsion potentials for the Amber ff99SB protein force field

(2010) Kresten Lindorff-Larsen et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

A Functional and Structural Study of Troponin C Mutations Related to Hypertrophic Cardiomyopathy

(2009) Jose Renato Pinto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Staggered Mesh Ewald: An Extension of the Smooth Particle-Mesh Ewald Method Adding Great Versatility

(2009) David S. Cerutti et al.   Journal of Chemical Theory and Computation

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

(2008) Andrew P. Landstrom et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility

(2008) Bo Liang et al.   PHYSIOLOGICAL GENOMICS