Restrictive Cardiomyopathy Troponin I R145W Mutation Does Not Perturb Myofilament Length-dependent Activation in Human Cardiac Sarcomeres

Troponin structure: its modulation by Ca2+ and phosphorylation studied by molecular dynamics simulations

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Titin strain contributes to the Frank–Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins

(2016) Younss Ait-Mou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapid large-scale purification of myofilament proteins using a cleavable His6-tag

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Effects of HCM cTnI Mutation R145G on Troponin Structure and Modulation by PKA Phosphorylation Elucidated by Molecular Dynamics Simulations

(2015) Steffen Lindert et al.   BIOPHYSICAL JOURNAL

Uncoupling of myofilament Ca2+sensitivity from troponin I phosphorylation by mutations can be reversed by epigallocatechin-3-gallate

(2015) Maria Papadaki et al.   CARDIOVASCULAR RESEARCH

Cardiac Myosin-binding Protein C and Troponin-I Phosphorylation Independently Modulate Myofilament Length-dependent Activation

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Troponin I Mutations R146G and R21C Alter Cardiac Troponin Function, Contractile Properties, and Modulation by Protein Kinase A (PKA)-mediated Phosphorylation

(2015) Yuanhua Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Length-dependent activation is modulated by cardiac troponin I bisphosphorylation at Ser23 and Ser24 but not by Thr143 phosphorylation

(2014) Paul J. M. Wijnker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Computational Studies of the Effect of the S23D/S24D Troponin I Mutation on Cardiac Troponin Structural Dynamics

(2014) Yuanhua Cheng et al.   BIOPHYSICAL JOURNAL

Inherited Cardiomyopathies

(2014) Jeffrey A. Towbin   CIRCULATION JOURNAL

Myocardial Infarction-induced N-terminal Fragment of Cardiac Myosin-binding Protein C (cMyBP-C) Impairs Myofilament Function in Human Myocardium

(2014) Namthip Witayavanitkul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel approaches to determine contractile function of the isolated adult zebrafish ventricular cardiac myocyte

(2014) Alexey V. Dvornikov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Heart failure: a special issue

(2014) Jolanda van der Velden et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Protein Kinase C Phosphomimetics Alter Thin Filament Ca2+ Binding Properties

(2014) Bin Liu et al.   PLoS One

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

Length dependence of striated muscle force generation is controlled by phosphorylation of cTnI at serines 23/24

(2013) Laurin M. Hanft et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impact of site-specific phosphorylation of protein kinase A sites Ser23 and Ser24 of cardiac troponin I in human cardiomyocytes

(2012) Paul J. M. Wijnker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

(2012) Pingbo Zhang et al.   CIRCULATION

AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I at Ser-150 to Increase Myofilament Calcium Sensitivity and Blunt PKA-dependent Function

(2012) Benjamin R. Nixon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle

(2012) Vijay S. Rao et al.   JOURNAL OF PHYSIOLOGY-LONDON

Protein kinase A changes calcium sensitivity but not crossbridge kinetics in human cardiac myofibrils

(2011) John S. Walker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Identifying Sarcomere Gene Mutations in Hypertrophic Cardiomyopathy

(2011) Christine E. Seidman et al.   CIRCULATION RESEARCH

Myofilament length dependent activation

(2010) Pieter P. de Tombe et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetics of Restrictive Cardiomyopathy

(2010) Srijita Sen-Chowdhry et al.   Heart Failure Clinics

Sarcomere length dependence of power output is increased after PKA treatment in rat cardiac myocytes

(2009) Laurin M. Hanft et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice

(2009) Yuhui Wen et al.   JOURNAL OF MOLECULAR BIOLOGY

Insights into the kinetics of Ca2+-regulated contraction and relaxation from myofibril studies

(2009) Robert Stehle et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants

(2008) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY