Long Term Ablation of Protein Kinase A (PKA)-mediated Cardiac Troponin I Phosphorylation Leads to Excitation-Contraction Uncoupling and Diastolic Dysfunction in a Knock-in Mouse Model of Hypertrophic Cardiomyopathy

Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

(2013) Vasco Sequeira et al.   CIRCULATION RESEARCH

Hydralazine and Organic Nitrates Restore Impaired Excitation-Contraction Coupling by Reducing Calcium Leak Associated with Nitroso-Redox Imbalance

(2013) Raul A. Dulce et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shortening baroreflex delay in hypertrophic cardiomyopathy patients - an unknown effect of β-blockers

(2012) Agnieszka Katarzynska-Szymanska et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Myofibrillar Ca2+ sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T

(2012) Christopher R. Bayliss et al.   CARDIOVASCULAR RESEARCH

Multiple Reaction Monitoring to Identify Site-Specific Troponin I Phosphorylated Residues in the Failing Human Heart

(2012) Pingbo Zhang et al.   CIRCULATION

Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy

(2012) Raffaele Coppini et al.   CIRCULATION

Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium

(2012) Brett A. Colson et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Diastolic dysfunction and thin filament dysregulation resulting from excitation–contraction uncoupling in a mouse model of restrictive cardiomyopathy

(2012) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

A Critical Function for Ser-282 in Cardiac Myosin Binding Protein-C Phosphorylation and Cardiac Function

(2011) Sakthivel Sadayappan et al.   CIRCULATION RESEARCH

Contractile Dysfunction Irrespective of the Mutant Protein in Human Hypertrophic Cardiomyopathy With Normal Systolic Function

(2011) Sabine J. van Dijk et al.   Circulation-Heart Failure

Low frequency power of heart rate variability reflects baroreflex function, not cardiac sympathetic innervation

(2011) Faisal Rahman et al.   CLINICAL AUTONOMIC RESEARCH

Generation and Functional Characterization of Knock-in Mice Harboring the Cardiac Troponin I-R21C Mutation Associated with Hypertrophic Cardiomyopathy

(2011) Yingcai Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Top-Down Quantitative Proteomics Identified Phosphorylation of Cardiac Troponin I as a Candidate Biomarker for Chronic Heart Failure

(2011) Jiang Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Mechanisms of disease: hypertrophic cardiomyopathy

(2011) Norbert Frey et al.   Nature Reviews Cardiology

Abnormal heart rate regulation in murine hearts with familial hypertrophic cardiomyopathy-related cardiac troponin T mutations

(2010) Jesus Jimenez et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Research Priorities in Hypertrophic Cardiomyopathy

(2010) Thomas Force et al.   CIRCULATION

Genetics of hypertrophic cardiomyopathy

(2010) Tetsuo Konno et al.   CURRENT OPINION IN CARDIOLOGY

Calcium sensitivity, force frequency relationship and cardiac troponin I: Critical role of PKA and PKC phosphorylation sites

(2010) Genaro A. Ramirez-Correa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Correcting diastolic dysfunction by Ca2+ desensitizing troponin in a transgenic mouse model of restrictive cardiomyopathy

(2010) Yuejin Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Why does troponin I have so many phosphorylation sites? Fact and fancy

(2010) R. John Solaro et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Rescue of familial cardiomyopathies by modifications at the level of sarcomere and Ca2+ fluxes

(2010) Marco L. Alves et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

In VivoPhosphorylation Site Mapping in Mouse Cardiac Troponin I by High Resolution Top-Down Electron Capture Dissociation Mass Spectrometry: Ser22/23 Are the Only Sites Basally Phosphorylated

(2009) Serife Ayaz-Guner et al.   BIOCHEMISTRY

Impairment of Diastolic Function by Lack of Frequency-Dependent Myofilament Desensitizationin Rabbit Right Ventricular Hypertrophy

(2009) Kenneth D. Varian et al.   Circulation-Heart Failure

Mutations in Troponin that cause HCM, DCM AND RCM: What can we learn about thin filament function?

(2009) Ruth H. Willott et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Functional Effects of a Restrictive-Cardiomyopathy-Linked Cardiac Troponin I Mutation (R145W) in Transgenic Mice

(2009) Yuhui Wen et al.   JOURNAL OF MOLECULAR BIOLOGY

Genetic determinants of cardiac hypertrophy

(2008) Ali J Marian   CURRENT OPINION IN CARDIOLOGY

Multiplex Kinase Signaling Modifies Cardiac Function at the Level of Sarcomeric Proteins

(2008) R. John Solaro   JOURNAL OF BIOLOGICAL CHEMISTRY

Challenging Current Paradigms Related to Cardiomyopathies

(2008) David Dweck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allele and species dependent contractile defects by restrictive and hypertrophic cardiomyopathy-linked troponin I mutants

(2008) Jennifer Davis et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Troponin phosphorylation and myofilament Ca2+-sensitivity in heart failure: Increased or decreased?

(2008) Steven B. Marston et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Expression of cTnI-R145G affects shortening properties of adult rat cardiomyocytes

(2008) Stephanie Reis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility

(2008) Bo Liang et al.   PHYSIOLOGICAL GENOMICS