Functional Characterization of 15 Novel Dense Granule Proteins in Toxoplasma gondii Using the CRISPR-Cas9 System

Functional Characterization of 17 Protein Serine/Threonine Phosphatases in Toxoplasma gondii Using CRISPR-Cas9 System

(2022) Qin-Li Liang et al.   Frontiers in Cell and Developmental Biology

Dense granule biogenesis, secretion, and function in Toxoplasma gondii

(2022) Michael B. Griffith et al.   JOURNAL OF EUKARYOTIC MICROBIOLOGY

Dense Granule Protein GRA64 Interacts with Host Cell ESCRT Proteins during Toxoplasma gondii Infection

(2022) Joshua Mayoral et al.   mBio

Functional Characterization of Two Thioredoxin Proteins of Toxoplasma gondii Using the CRISPR-Cas9 System

(2021) Zhi-Wei Zhang et al.   Frontiers in Veterinary Science

A Family of Toxoplasma gondii Genes Related to GRA12 Regulate Cyst Burdens and Cyst Reactivation

(2021) Rebekah B. Guevara et al.   mSphere

Characterization of functions in parasite growth and virulence of four Toxoplasma gondii genes involved in lipid synthesis by CRISPR-Cas9 system

(2021) Jie Liu et al.   PARASITOLOGY RESEARCH

Toxoplasma gondii Matrix Antigen 1 Is a Secreted Immunomodulatory Effector

(2021) Tadakimi Tomita et al.   mBio

Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins

(2021) Yolanda Rivera-Cuevas et al.   PLoS Pathogens

Novel roles of dense granule protein 12 (GRA12) in Toxoplasma gondii infection

(2020) Jin‐Lei Wang et al.   FASEB JOURNAL

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Regulate Maturation of the Cyst Wall

(2020) Rebekah B. Guevara et al.   mSphere

Coimmunoprecipitation with MYR1 Identifies Three Additional Proteins within the Toxoplasma gondii Parasitophorous Vacuole Required for Translocation of Dense Granule Effectors into Host Cells

(2020) Alicja M. Cygan et al.   mSphere

The Secreted Acid Phosphatase Domain-Containing GRA44 from Toxoplasma gondii Is Required for c-Myc Induction in Infected Cells

(2020) William J. Blakely et al.   mSphere

RHΔgra17Δnpt1 Strain of Toxoplasma gondii Elicits Protective Immunity Against Acute, Chronic and Congenital Toxoplasmosis in Mice

(2020) Qin-Li Liang et al.   Microorganisms

Proximity biotinylation reveals novel secreted dense granule proteins of Toxoplasma gondii bradyzoites

(2020) Santhosh Mukund Nadipuram et al.   PLoS One

Toxoplasma Mechanisms for Delivery of Proteins and Uptake of Nutrients Across the Host-Pathogen Interface

(2020) Yifan Wang et al.   Annual Review of Microbiology

Effect of deletion of gra17 and gra23 genes on the growth, virulence, and immunogenicity of type II Toxoplasma gondii

(2020) Ting-Ting Li et al.   PARASITOLOGY RESEARCH

A Comprehensive Subcellular Atlas of the Toxoplasma Proteome via hyperLOPIT Provides Spatial Context for Protein Functions

(2020) Konstantin Barylyuk et al.   Cell Host & Microbe

Toxoplasma gondii   GRA60 is an effector protein that modulates host cell autonomous immunity and contributes to virulence

(2020) Mary Akinyi Nyonda et al.   CELLULAR MICROBIOLOGY

Genome-wide screens identify Toxoplasma gondii determinants of parasite fitness in IFNγ-activated murine macrophages

(2020) Yifan Wang et al.   Nature Communications

Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis

(2020) Hany M. Elsheikha et al.   CLINICAL MICROBIOLOGY REVIEWS

Toxoplasma gondii PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector export

(2020) Joshua Mayoral et al.   PLoS Pathogens

Three Toxoplasma gondii Dense Granule Proteins Are Required for Induction of Lewis Rat Macrophage Pyroptosis

(2019) Yifan Wang et al.   mBio

The Toxoplasma gondii dense granule protein TgGRA3 interacts with host Golgi and dysregulates anterograde transport

(2019) Maika S. Deffieu et al.   Biology Open

Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities, and Perspectives

(2019) Jin-Lei Wang et al.   TRENDS IN PARASITOLOGY

Divergent kinase regulates membrane ultrastructure of theToxoplasmaparasitophorous vacuole

(2019) Tsebaot Beraki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enrichment and Proteomic Characterization of the Cyst Wall from In Vitro Toxoplasma gondii Cysts

(2019) Vincent Tu et al.   mBio

Toxoplasma Controls Host Cyclin E Expression through the Use of a Novel MYR1-Dependent Effector Protein, HCE1

(2019) Michael W. Panas et al.   mBio

The triumvirate of signaling molecules controlling Toxoplasma microneme exocytosis: Cyclic GMP, calcium, and phosphatidic acid

(2019) Hayley E. Bullen et al.   PLoS Pathogens

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

(2019) Laurence Braun et al.   Nature Microbiology

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

(2019) Barbara A. Fox et al.   mBio

The GRA17 Parasitophorous Vacuole Membrane Permeability Pore Contributes to Bradyzoite Viability

(2019) Tatiana Paredes-Santos et al.   Frontiers in Cellular and Infection Microbiology

Toxoplasma gondii Intravacuolar-Network-Associated Dense Granule Proteins Regulate Maturation of the Cyst Matrix and Cyst Wall

(2019) Rebekah B. Guevara et al.   mSphere

Characterization of the Role of Amylo-Alpha-1,6-Glucosidase Protein in the Infectivity of Toxoplasma gondii

(2019) Xue-Zhen Cao et al.   Frontiers in Cellular and Infection Microbiology

Functional Characterization of Dense Granule Proteins in Toxoplasma gondii RH Strain Using CRISPR-Cas9 System

(2018) Meng-Jie Bai et al.   Frontiers in Cellular and Infection Microbiology

Identification of Novel Dense-Granule Proteins in Toxoplasma gondii by Two Proximity-Based Biotinylation Approaches

(2018) Ming Pan et al.   JOURNAL OF PROTEOME RESEARCH

Aspartyl Protease 5 Matures Dense Granule Proteins That Reside at the Host-Parasite Interface in Toxoplasma gondii

(2018) Michael J. Coffey et al.   mBio

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

(2018) Huan He et al.   eLife

The parasiteToxoplasmasequesters diverse Rab host vesicles within an intravacuolar network

(2017) Julia D. Romano et al.   JOURNAL OF CELL BIOLOGY

The Toxoplasma Parasitophorous Vacuole: An Evolving Host–Parasite Frontier

(2017) Barbara Clough et al.   TRENDS IN PARASITOLOGY

Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis

(2017) Ze-Dong Wang et al.   Lancet HIV

A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes

(2016) Saima M. Sidik et al.   CELL

Toxoplasma Effector Recruits the Mi-2/NuRD Complex to Repress STAT1 Transcription and Block IFN-γ-Dependent Gene Expression

(2016) Philipp Olias et al.   Cell Host & Microbe

Toxoplasma gondiiTgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ–mediated host defenses

(2016) Gabrielle Gay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma gondii Cyclic AMP-Dependent Protein Kinase Subunit 3 Is Involved in the Switch from Tachyzoite to Bradyzoite Development

(2016) Tatsuki Sugi et al.   mBio

In Vivo Biotinylation of the Toxoplasma Parasitophorous Vacuole Reveals Novel Dense Granule Proteins Important for Parasite Growth and Pathogenesis

(2016) Santhosh M. Nadipuram et al.   mBio

Phenotypes Associated with Knockouts of Eight Dense Granule Gene Loci (GRA2-9) in Virulent Toxoplasma gondii

(2016) Leah M. Rommereim et al.   PLoS One

The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole

(2015) Daniel A. Gold et al.   Cell Host & Microbe

TheToxoplasma gondiirhoptry protein ROP18 is an Irga6-specific kinase and regulated by the dense granule protein GRA7

(2015) Thomas Hermanns et al.   CELLULAR MICROBIOLOGY

Evaluation of the basic functions of six calcium-dependent protein kinases in Toxoplasma gondii using CRISPR-Cas9 system

(2015) Jin-Lei Wang et al.   PARASITOLOGY RESEARCH

Toxoplasma secretory granules: one population or more?

(2015) Corinne Mercier et al.   TRENDS IN PARASITOLOGY

Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite Interface

(2015) Pierre-Mehdi Hammoudi et al.   PLoS Pathogens

An aspartyl protease defines a novel pathway for export of Toxoplasma proteins into the host cell

(2015) Michael J Coffey et al.   eLife

Selective and strain-specific NFAT4 activation by theToxoplasma gondiipolymorphic dense granule protein GRA6

(2014) Ji Su Ma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma gondii Ingests and Digests Host Cytosolic Proteins

(2014) Z. Dou et al.   mBio

Host Cell Subversion by Toxoplasma GRA16, an Exported Dense Granule Protein that Targets the Host Cell Nucleus and Alters Gene Expression

(2013) Alexandre Bougdour et al.   Cell Host & Microbe

AToxoplasmadense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation

(2013) Laurence Braun et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole

(2013) Julia D. Romano et al.   MOLECULAR BIOLOGY OF THE CELL

The Toxoplasma gondii Cyst Wall Protein CST1 Is Critical for Cyst Wall Integrity and Promotes Bradyzoite Persistence

(2013) Tadakimi Tomita et al.   PLoS Pathogens

Transcriptomic Analysis of Toxoplasma Development Reveals Many Novel Functions and Structures Specific to Sporozoites and Oocysts

(2012) Heather M. Fritz et al.   PLoS One

Identification of Tissue Cyst Wall Components by Transcriptome Analysis of In Vivo and In Vitro Toxoplasma gondii Bradyzoites

(2011) Kerry R. Buchholz et al.   EUKARYOTIC CELL

Strain-specific activation of the NF-κB pathway by GRA15, a novelToxoplasma gondiidense granule protein

(2011) Emily E. Rosowski et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Coordinated Progression through Two Subtranscriptomes Underlies the Tachyzoite Cycle of Toxoplasma gondii

(2010) Michael S. Behnke et al.   PLoS One

Host-derived glucose and its transporter in the obligate intracellular pathogen Toxoplasma gondii are dispensable by glutaminolysis

(2009) M. Blume et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host cell manipulation by the human pathogen Toxoplasma gondii

(2008) J. Laliberté et al.   CELLULAR AND MOLECULAR LIFE SCIENCES