Sphingolipids and Atherosclerosis: The Dual Role of Ceramide and Sphingosine-1-Phosphate
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Title
Sphingolipids and Atherosclerosis: The Dual Role of Ceramide and Sphingosine-1-Phosphate
Authors
Keywords
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Journal
Antioxidants
Volume 12, Issue 1, Pages 143
Publisher
MDPI AG
Online
2023-01-09
DOI
10.3390/antiox12010143
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Note: Only part of the references are listed.- Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis
- (2022) Ying Li et al. Scientific Reports
- Lipidomics Analysis Reveals a Protective Effect of Myriocin on Cerebral Ischemia/Reperfusion Model Rats
- (2022) Ting Wang et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Ceramide Metabolism in Cardiovascular Disease: A Network With High Therapeutic Potential
- (2022) Andreas Zietzer et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction
- (2022) Yang Ji et al. CARDIOVASCULAR DRUGS AND THERAPY
- Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production
- (2022) Daorong Pan et al. CELLULAR SIGNALLING
- Sphingolipids in Atherosclerosis: Chimeras in Structure and Function
- (2022) Lisa Peters et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Sphingosine-1-Phosphate (S1P) Lyase Inhibition Aggravates Atherosclerosis and Induces Plaque Rupture in ApoE−/− Mice
- (2022) Petra Keul et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Regulation of serine palmitoyl-transferase and Rac1–Nox2 signaling in diabetic retinopathy
- (2022) Kumari Alka et al. Scientific Reports
- Sphingolipid metabolism and signaling in cardiovascular diseases
- (2022) Sonia Borodzicz-Jażdżyk et al. Frontiers in Cardiovascular Medicine
- Novel insight on the role of Macrophages in atherosclerosis: Focus on polarization, apoptosis and efferocytosis
- (2022) Yingying Xie et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Acid sphingomyelinase promotes SGK1-dependent vascular calcification
- (2021) Trang Thi Doan Luong et al. CLINICAL SCIENCE
- The antithetic role of ceramide and sphingosine‐1‐phosphate in cardiac dysfunction
- (2021) Federica Cirillo et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Fate and State of Vascular Smooth Muscle Cells in Atherosclerosis
- (2021) Joseph M. Miano et al. CIRCULATION
- Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism
- (2021) Bernadette Breiden et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides
- (2021) Andreas Zietzer et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Ceramide accumulation induces mitophagy and impairs β-oxidation in PINK1 deficiency
- (2021) Melissa Vos et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Vascular endothelial S1pr1 ameliorates adverse cardiac remodeling via stimulating reparative macrophage proliferation after myocardial infarction
- (2020) Yashu Kuang et al. CARDIOVASCULAR RESEARCH
- Myriocin and d-PDMP ameliorate atherosclerosis in ApoE−/− mice via reducing lipid uptake and vascular inflammation
- (2020) Zemou Yu et al. CLINICAL SCIENCE
- Role of Endothelial Dysfunction in Cardiovascular Diseases: The Link Between Inflammation and Hydrogen Sulfide
- (2020) Hai-Jian Sun et al. Frontiers in Pharmacology
- Reign in the membrane: How common lipids govern mitochondrial function
- (2020) Katsuhiko Funai et al. CURRENT OPINION IN CELL BIOLOGY
- Endothelial Sphingolipid De Novo Synthesis Controls Blood Pressure by Regulating Signal Transduction and NO via Ceramide
- (2020) Anna Cantalupo et al. HYPERTENSION
- Associations between plasma ceramides and mortality in patients with coronary artery disease
- (2020) Qing Li et al. ATHEROSCLEROSIS
- Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis
- (2020) Chainika Khatana et al. Oxidative Medicine and Cellular Longevity
- Endothelial dysfunction in small arteries and early signs of atherosclerosis in ApoE knockout rats
- (2020) Simin Berenji Ardestani et al. Scientific Reports
- Dihydroceramides: their emerging physiological roles and functions in cancer and metabolic diseases
- (2020) Floriane Lachkar et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Biochemistry of very-long-chain and long-chain ceramides in cystic fibrosis and other diseases: The importance of side chain
- (2019) Dušan Garić et al. PROGRESS IN LIPID RESEARCH
- Antioxidants and Atherosclerosis: Mechanistic Aspects
- (2019) Khojasteh Malekmohammad et al. Biomolecules
- Associations between specific plasma ceramides and severity of coronary-artery stenosis assessed by coronary angiography
- (2019) A. Mantovani et al. DIABETES & METABOLISM
- Sphingolipid Synthesis Inhibition by Myriocin Administration Enhances Lipid Consumption and Ameliorates Lipid Response to Myocardial Ischemia Reperfusion Injury
- (2019) Fabiola Bonezzi et al. Frontiers in Physiology
- Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation
- (2019) Kazuhiro Ishimaru et al. Scientific Reports
- The Physical Properties of Ceramides in Membranes
- (2018) Alicia Alonso et al. Annual Review of Biophysics
- Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths
- (2018) Maija Ruuth et al. EUROPEAN HEART JOURNAL
- Sphingosine 1-Phosphate and Atherosclerosis
- (2018) Makoto Kurano et al. Journal of Atherosclerosis and Thrombosis
- Cortactin: Cell Functions of A Multifaceted Actin-Binding Protein
- (2018) Michael Schnoor et al. TRENDS IN CELL BIOLOGY
- Sphingosine -1 Phosphate Receptor-1 signaling maintains endothelial cell barrier function and protects against immune complex-induced vascular injury
- (2018) Nathalie Burg et al. Arthritis & Rheumatology
- The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration
- (2018) Henryk Jęśko et al. MOLECULAR NEUROBIOLOGY
- Elevating Endogenous Sphingosine-1-Phosphate (S1P) Levels Improves Endothelial Function and Ameliorates Atherosclerosis in Low Density Lipoprotein Receptor-Deficient (LDL-R−/−) Mice
- (2018) Renata Feuerborn et al. THROMBOSIS AND HAEMOSTASIS
- ApoM-S1P Modulates Ox-LDL-Induced Inflammation Through the PI3K/Akt Signaling Pathway in HUVECs
- (2018) Zhi Zheng et al. INFLAMMATION
- Plasma ceramides and cardiac risk
- (2017) Mark Nicholls EUROPEAN HEART JOURNAL
- TLR4/NF-κB/Ceramide signaling contributes to Ox-LDL-induced calcification of human vascular smooth muscle cells
- (2017) Yan Song et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Sphingosine-1-Phosphate Metabolism and Its Role in the Development of Inflammatory Bowel Disease
- (2017) Tomasz Wollny et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Identification of Sphingosine 1-Phosphate Receptor Subtype 1 (S1P1) as a Pathogenic Factor in Transient Focal Cerebral Ischemia
- (2017) Bhakta Prasad Gaire et al. MOLECULAR NEUROBIOLOGY
- Sphingolipids Contribute to Human Atherosclerotic Plaque InflammationHighlights
- (2016) Andreas Edsfeldt et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Vascular Smooth Muscle Cells in Atherosclerosis
- (2016) Martin R. Bennett et al. CIRCULATION RESEARCH
- Thirty Years of Saying NO
- (2016) Paul M. Vanhoutte et al. CIRCULATION RESEARCH
- Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol
- (2016) Reijo Laaksonen et al. EUROPEAN HEART JOURNAL
- Acid Sphingomyelinase Mediates Oxidized-LDL Induced Apoptosis in Macrophage via Endoplasmic Reticulum Stress
- (2016) Min Zhao et al. Journal of Atherosclerosis and Thrombosis
- Physiology and pathophysiology of oxLDL uptake by vascular wall cells in atherosclerosis
- (2016) Natalia Di Pietro et al. VASCULAR PHARMACOLOGY
- Macrophages and Their Role in Atherosclerosis: Pathophysiology and Transcriptome Analysis
- (2016) Yuri V. Bobryshev et al. Biomed Research International
- Akt/eNOS signaling pathway mediates inhibition of endothelial progenitor cells by palmitate-induced ceramide
- (2015) Minghuan Fu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Chemokines Control Mobilization, Recruitment, and Fate of Monocytes in Atherosclerosis
- (2015) M. Drechsler et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Plasma concentrations of molecular lipid species in relation to coronary plaque characteristics and cardiovascular outcome: Results of the ATHEROREMO-IVUS study
- (2015) Jin M. Cheng et al. ATHEROSCLEROSIS
- Inhibitor-1 and -2 of PP2A have preference between PP2A complexes
- (2015) Hirotsugu Hino et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2
- (2015) Martina Burczyk et al. BIOCHEMISTRY
- Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization
- (2015) Vinodh Rajagopalan et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Ceramide-Initiated Protein Phosphatase 2A Activation Contributes to Arterial Dysfunction In Vivo
- (2015) Leena P. Bharath et al. DIABETES
- Revisiting the sphingolipid rheostat: Evolving concepts in cancer therapy
- (2015) Jason Newton et al. EXPERIMENTAL CELL RESEARCH
- Role of sphingosine-1-phosphate receptor 1 and sphingosine-1-phosphate receptor 2 in hyperglycemia-induced endothelial cell dysfunction
- (2015) SHUHUA CHEN et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Recent insights into the cellular biology of atherosclerosis
- (2015) Ira Tabas et al. JOURNAL OF CELL BIOLOGY
- Ceramide-Activated Phosphatase Mediates Fatty Acid–Induced Endothelial VEGF Resistance and Impaired Angiogenesis
- (2014) Vishal C. Mehra et al. AMERICAN JOURNAL OF PATHOLOGY
- Lipidomic “Deep Profiling”: An Enhanced Workflow to Reveal New Molecular Species of Signaling Lipids
- (2014) Pradeep Narayanaswamy et al. ANALYTICAL CHEMISTRY
- NADPH oxidases: an overview from structure to innate immunity-associated pathologies
- (2014) Arvind Panday et al. Cellular & Molecular Immunology
- HDL-Bound Sphingosine 1-Phosphate (S1P) Predicts the Severity of Coronary Artery Atherosclerosis
- (2014) Katherine Sattler et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Ceramide Changes the Mediator of Flow-Induced Vasodilation From Nitric Oxide to Hydrogen Peroxide in the Human Microcirculation
- (2014) Julie K. Freed et al. CIRCULATION RESEARCH
- An update on the biology of sphingosine 1-phosphate receptors
- (2014) Victoria A. Blaho et al. JOURNAL OF LIPID RESEARCH
- Endogenous Ceramide Contributes to the Transcytosis of oxLDL across Endothelial Cells and Promotes Its Subendothelial Retention in Vascular Wall
- (2014) Wenjing Li et al. Oxidative Medicine and Cellular Longevity
- Matrix Metalloproteinase 7 Is Associated with Symptomatic Lesions and Adverse Events in Patients with Carotid Atherosclerosis
- (2014) Azhar Abbas et al. PLoS One
- Hydrogen peroxide signaling in vascular endothelial cells
- (2014) Rosa Bretón-Romero et al. Redox Biology
- KRP-203, Sphingosine 1-Phosphate Receptor Type 1 Agonist, Ameliorates Atherosclerosis in LDL-R −/− Mice
- (2013) Francesco Potì et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M
- (2013) Makoto Kurano et al. ATHEROSCLEROSIS
- A signaling cascade mediated by ceramide, src and PDGFRβ coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1
- (2013) Christel Cinq-Frais et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Ceramide and the mitochondrial respiratory chain
- (2013) Aviram Kogot-Levin et al. BIOCHIMIE
- Oxidative stress in angiogenesis and vascular disease
- (2013) Y.-W. Kim et al. BLOOD
- HDL and endothelial protection
- (2013) A Tran-Dinh et al. BRITISH JOURNAL OF PHARMACOLOGY
- The Apolipoprotein M–Sphingosine-1-Phosphate Axis: Biological Relevance in Lipoprotein Metabolism, Lipid Disorders and Atherosclerosis
- (2013) Bas Arkensteijn et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Molecular Lipids Identify Cardiovascular Risk and Are Efficiently Lowered by Simvastatin andPCSK9Deficiency
- (2013) Kirill Tarasov et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Molecular Biology of Atherosclerosis
- (2013) Paul N. Hopkins PHYSIOLOGICAL REVIEWS
- Ceramide Mediates Ox-LDL-Induced Human Vascular Smooth Muscle Cell Calcification via p38 Mitogen-Activated Protein Kinase Signaling
- (2013) Lizhen Liao et al. PLoS One
- Shaping the landscape: Metabolic regulation of S1P gradients
- (2012) Ana Olivera et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Ceramide Mediates Vascular Dysfunction in Diet-Induced Obesity by PP2A-Mediated Dephosphorylation of the eNOS-Akt Complex
- (2012) Q.-J. Zhang et al. DIABETES
- Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis
- (2012) Dan Gao et al. FREE RADICAL BIOLOGY AND MEDICINE
- Long chain ceramides and very long chain ceramides have opposite effects on human breast and colon cancer cell growth
- (2012) Daniela Hartmann et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Sphingosine 1-Phosphate (S1P) Carrier-dependent Regulation of Endothelial Barrier
- (2012) Brent A. Wilkerson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH
- (2012) Mia Sneck et al. JOURNAL OF LIPID RESEARCH
- FTY720 Protects Cardiac Microvessels of Diabetes: A Critical Role of S1P1/3 in Diabetic Heart Disease
- (2012) Zhiyong Yin et al. PLoS One
- From form to function: the role of Nox4 in the cardiovascular system
- (2012) Feng Chen et al. Frontiers in Physiology
- Mechanisms of lung endothelial barrier disruption induced by cigarette smoke: role of oxidative stress and ceramides
- (2011) Kelly S. Schweitzer et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Inhibition of ceramide synthesis reverses endothelial dysfunction and atherosclerosis in streptozotocin-induced diabetic rats
- (2011) Li Chun et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- S1P, dihydro-S1P and C24:1-ceramide levels in the HDL-containing fraction of serum inversely correlate with occurrence of ischemic heart disease
- (2011) Kelley M Argraves et al. Lipids in Health and Disease
- Endothelium-protective sphingosine-1-phosphate provided by HDL-associated apolipoprotein M
- (2011) C. Christoffersen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Caveolae and caveolin-1 mediate endocytosis and transcytosis of oxidized low density lipoprotein in endothelial cells
- (2010) Shao-wei Sun et al. ACTA PHARMACOLOGICA SINICA
- Sphingosine-1-Phosphate Receptor-2 Function in Myeloid Cells Regulates Vascular Inflammation and Atherosclerosis
- (2010) Athanasia Skoura et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Sphingosine 1-phosphate levels in plasma and HDL are altered in coronary artery disease
- (2010) Katherine J. E. Sattler et al. BASIC RESEARCH IN CARDIOLOGY
- The mechanical triggers of plaque rupture: shear stressvspressure gradient
- (2010) Z-Y Li et al. BRITISH JOURNAL OF RADIOLOGY
- Ceramide in Redox Signaling and Cardiovascular Diseases
- (2010) Xiang Li et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction
- (2010) Giovanna Frazziano et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Blood sphingolipidomics in healthy humans: impact of sample collection methodology
- (2010) Samar M. Hammad et al. JOURNAL OF LIPID RESEARCH
- Sphingosine 1-Phosphate (S1P) Regulates Vascular Contraction via S1P3 Receptor: Investigation Based on a New S1P3 Receptor Antagonist
- (2010) A. Murakami et al. MOLECULAR PHARMACOLOGY
- International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid Receptor Nomenclature
- (2010) J. Chun et al. PHARMACOLOGICAL REVIEWS
- Sphingosine-1-phosphate as a mediator of high-density lipoprotein effects in cardiovascular protection
- (2009) K. Sattler et al. CARDIOVASCULAR RESEARCH
- Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology
- (2009) Catherine Pavoine et al. CARDIOVASCULAR RESEARCH
- Reprint of “The role of cytoskeleton in the regulation of vascular endothelial barrier function” [Microvascular Research 76 (2008) 202–207]
- (2009) Natalia V. Bogatcheva et al. MICROVASCULAR RESEARCH
- HDL-Associated Lysosphingolipids Inhibit NAD(P)H Oxidase-Dependent Monocyte Chemoattractant Protein-1 Production
- (2008) Markus Tölle et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- Acid Sphingomyelinase Promotes Lipoprotein Retention Within Early Atheromata and Accelerates Lesion Progression
- (2008) Cecilia M. Devlin et al. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
- S1P and eNOS regulation
- (2008) J IGARASHI BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The vascular S1P gradient—Cellular sources and biological significance
- (2008) T HLA BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Selective attenuation of Toll-like receptor 2 signalling may explain the atheroprotective effect of sphingosine 1-phosphate
- (2008) A. I. Duenas et al. CARDIOVASCULAR RESEARCH
- The sphingolipid salvage pathway in ceramide metabolism and signaling
- (2008) Kazuyuki Kitatani et al. CELLULAR SIGNALLING
- Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate
- (2008) Krishnan Venkataraman et al. CIRCULATION RESEARCH
- Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration
- (2008) Murray C.H. Clarke et al. CIRCULATION RESEARCH
- High Density Lipoprotein-associated Sphingosine 1-Phosphate Promotes Endothelial Barrier Function
- (2008) Kelley M. Argraves et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases
- (2008) J. M. van Gils et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Mechanisms and consequences of macrophage apoptosis in atherosclerosis
- (2008) Tracie Seimon et al. JOURNAL OF LIPID RESEARCH
- Ceramide is a cardiotoxin in lipotoxic cardiomyopathy
- (2008) Tae-Sik Park et al. JOURNAL OF LIPID RESEARCH
- Effect of Sphingomyelinase-Mediated Generation of Ceramide on Aggregation of Low-Density Lipoprotein
- (2008) Michael J. Walters et al. LANGMUIR
- Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies
- (2008) C. A. Corcoran et al. MOLECULAR CANCER RESEARCH
- Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: Effect of simvastatin
- (2008) María González-Díez et al. THROMBOSIS AND HAEMOSTASIS
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