Metal Coordination and Biological Screening of a Schiff Base Derived from 8-Hydroxyquinoline and Benzothiazole

Synthesis, structure and anticancer studies of Cu(Ⅱ) and Ni(Ⅱ) complexes based on 2-hydroxy-1-naphthaldehyde-4-aminoantipyrine Schiff-base

(2022) Jiajia Qi et al.   JOURNAL OF MOLECULAR STRUCTURE

Liposomal Formulations of a New Zinc(II) Complex Exhibiting High Therapeutic Potential in a Murine Colon Cancer Model

(2022) Nádia Ribeiro et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic potential of a copper complex loaded in pH-sensitive long circulating liposomes for colon cancer management

(2021) Jacinta O. Pinho et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Strawberry tree honey in combination with 5-fluorouracil enhances chemosensitivity in human colon adenocarcinoma cells

(2021) Sadia Afrin et al.   FOOD AND CHEMICAL TOXICOLOGY

Synthesis, characterization of ruthenium(II), nickel(II), palladium(II), and platinum(II) triphenylphosphine-based complexes bearing an ONS-donor chelating agent: Interaction with biomolecules, antioxidant, in vitro cytotoxic, apoptotic activity and cell cycle analysis

(2021) Shadia A. Elsayed et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Apigenin enhances apoptosis induction by 5-fluorouracil through regulation of thymidylate synthase in colorectal cancer cells

(2021) Changwon Yang et al.   Redox Biology

The Aquaporin-3-Inhibiting Potential of Polyoxotungstates

(2020) Catarina Pimpão et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nickel and zinc complexes of testosterone N4-substituted thiosemicarbazone: Selective cytotoxicity towards human colorectal carcinoma cell line HCT 116 and their cell death mechanisms

(2020) Mok Piew Heng et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Novel NHC-coordinated ruthenium(II) arene complexes achieve synergistic efficacy as safe and effective anticancer therapeutics

(2020) Chao Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Antitumor Activity of Ruthenium(II) Terpyridine Complexes towards Colon Cancer Cells In Vitro and In Vivo

(2020) Maja Savic et al.   MOLECULES

The Encapsulation of Febuxostat into Emulsomes Strongly Enhances the Cytotoxic Potential of the Drug on HCT 116 Colon Cancer Cells

(2020) Usama A. Fahmy et al.   Pharmaceutics

Potent half-sandwich Ru(Ⅱ) N^N (aryl-BIAN) complexes: Lysosome-mediated apoptosis, in vitro and in vivo anticancer activities

(2020) Zhishan Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Development and In Vitro Evaluation of 5-Fluorouracil-Eluting Stents for the Treatment of Colorectal Cancer and Cancer-Related Obstruction

(2020) Mohammad Arafat et al.   Pharmaceutics

Isatin-1,8-Naphthalimide Hydrazones: A Study of Their Sensor and ON/OFF Functionality

(2019) Pavol Tisovský et al.   MOLECULES

Cisplatin: The first metal based anticancer drug

(2019) Sumit Ghosh   BIOORGANIC CHEMISTRY

Schiff base-nickel, palladium, and platinum complexes derived from N -cyclohexyl hydrazine carbothioamide and 3-hydroxy-4-methoxybenzaldehyde: Selective antiproliferative and proapoptotic effects against colorectal carcinoma

(2019) Md. Azharul Arafath et al.   DRUG DEVELOPMENT RESEARCH

Cytotoxicity, Genotoxicity and Disturbance of Cell Cycle in HepG2 Cells Exposed to OTA and BEA: Single and Combined Actions

(2019) Ana Juan-García et al.   Toxins

In vitro Cell Migration, Invasion, and Adhesion Assays: From Cell Imaging to Data Analysis

(2019) Jordi Pijuan et al.   Frontiers in Cell and Developmental Biology

Hydroxyquinoline-derived anticancer organometallics: Introduction of amphiphilic PTA as an ancillary ligand increases their aqueous solubility

(2019) William D.J. Tremlett et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Vanadium(V) and Molybdenum(VI) Complexes Containing ONO Tridentate Schiff Bases and Their Application as Catalysts for Oxidative Bromination of Phenols

(2019) Mannar R. Maurya et al.   ChemistrySelect

Syntheses, Crystal Structures, and Antitumor Activities of Copper(II) and Nickel(II) Complexes with 2-((2-(Pyridin-2-yl)hydrazono)methyl)quinolin-8-ol

(2018) Qi-Yuan Yang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Deciphering the biochemical and molecular mechanism underlying the in vitro and in vivo chemotherapeutic efficacy of ruthenium quercetin complex in colon cancer

(2018) Souvik Roy et al.   MOLECULAR CARCINOGENESIS

Systemic Therapy for Colon Cancer

(2018) Christina Wu   Surgical Oncology Clinics of North America

A ruthenium-based 5-fluorouracil complex with enhanced cytotoxicity and apoptosis induction action in HCT116 cells

(2018) Valdenizia Rodrigues Silva et al.   Scientific Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Small benzothiazole molecule induces apoptosis and prevents metastasis through DNA interaction and c-MYC gene supression in diffuse-type gastric adenocarcinoma cell line

(2018) Felipe Pantoja Mesquita et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Development of Parvifloron D-loaded Smart Nanoparticles to Target Pancreatic Cancer

(2018) Ana Santos-Rebelo et al.   Pharmaceutics

Synthesis, structural investigations, DFT, molecular docking and antifungal studies of transition metal complexes with benzothiazole based Schiff base ligands

(2018) Ranjan K. Mohapatra et al.   JOURNAL OF MOLECULAR STRUCTURE

Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays

(2017) Paul T. Bremer et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Benzothiazole Derivative (5g) Induces DNA Damage And Potent G2/M Arrest In Cancer Cells

(2017) Mahesh Hegde et al.   Scientific Reports

Antiangiogenic activity of 2-formyl-8-hydroxy-quinolinium chloride

(2016) K.-H. Lam et al.   BIOMEDICINE & PHARMACOTHERAPY

Preparation of 4-([2,2′:6′,2″-terpyridin]-4′-yl)-N,N-diethylaniline Ni II and Pt II complexes and exploration of their in vitro cytotoxic activities

(2016) Hua-Hong Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of adhesion, migration and of α5β1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A

(2016) Chiara Pelillo et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Nanoformulations of a potent copper-based aquaporin inhibitor with cytotoxic effect against cancer cells

(2016) Mariana Nave et al.   Nanomedicine

Amine Functionalization via Oxidative Photoredox Catalysis: Methodology Development and Complex Molecule Synthesis

(2015) Joel W. Beatty et al.   ACCOUNTS OF CHEMICAL RESEARCH

A 2-(2′-hydroxyphenyl)benzothiazole (HBT)–quinoline conjugate: a highly specific fluorescent probe for Hg2+ based on ESIPT and its application in bioimaging

(2015) Sunanda Sahana et al.   DALTON TRANSACTIONS

Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8-Hydroxyquinoline Anticancer Agents

(2015) Mario Kubanik et al.   ORGANOMETALLICS

Targeting KRAS Oncogene in Colon Cancer Cells with 7-Carboxylate Indolo[3,2-b]quinoline Tri-Alkylamine Derivatives

(2015) Hugo Brito et al.   PLoS One

8-Hydroxyquinoline: a privileged structure with a broad-ranging pharmacological potential

(2015) Yu'ning Song et al.   MedChemComm

Benzothiazoles: How Relevant in Cancer Drug Design Strategy?

(2014) Meenakshi Singh et al.   Anti-Cancer Agents in Medicinal Chemistry

Synthesis and anticancer activity of (E)-2-benzothiazole hydrazones

(2014) Eric B. Lindgren et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Biological evaluation of new nickel(II) metallates: Synthesis, DNA/protein binding and mitochondrial mediated apoptosis in human lung cancer cells (A549) via ROS hypergeneration and depletion of cellular antioxidant pool

(2014) P. Kalaivani et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Phase I/II study with ruthenium compound NAMI-A and gemcitabine in patients with non-small cell lung cancer after first line therapy

(2014) Suzanne Leijen et al.   INVESTIGATIONAL NEW DRUGS

Synthesis, characterization, crystal structures and biological activity of set of Cu(II) benzothiazole complexes: Artificial nucleases with cytotoxic activities

(2014) Ramsey A. Steiner et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Oxidative Stress Induced by Copper and Iron Complexes with 8-Hydroxyquinoline Derivatives Causes Paraptotic Death of HeLa Cancer Cells

(2014) Amelia Barilli et al.   MOLECULAR PHARMACEUTICS

Preparation of 8-hydroxyquinoline derivatives as potential antibiotics against Staphylococcus aureus

(2013) Kim-Hung Lam et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Copper(ii) complexes with 2NO and 3N donor ligands: synthesis, structures and chemical nuclease and anticancer activities

(2013) Chandrasekaran Rajarajeswari et al.   DALTON TRANSACTIONS

Application of Ratiometric Measurements and Microplate Fluorimetry to Protein Denaturation: An Experiment for Analytical and Biochemistry Students

(2013) Joaquim T. Marquês et al.   JOURNAL OF CHEMICAL EDUCATION

Comparative solution equilibrium studies of anticancer gallium(III) complexes of 8-hydroxyquinoline and hydroxy(thio)pyrone ligands

(2012) Éva A. Enyedy et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Synthesis of 8-Hydroxyquinoline Derivatives as Novel Antitumor Agents

(2012) Sau Hing Chan et al.   ACS Medicinal Chemistry Letters

Synthesis, spectral characterization, solution equilibria, in vitro antibacterial and cytotoxic activities of Cu(II), Ni(II), Mn(II), Co(II) and Zn(II) complexes with Schiff base derived from 5-bromosalicylaldehyde and 2-aminomethylthiophene

(2011) Ahmed A. El-Sherif et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Configurational and Constitutional Information Storage: Multiple Dynamics in Systems Based on Pyridyl and Acyl Hydrazones

(2010) Manuel N. Chaur et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel Metals and Metal Complexes as Platforms for Cancer Therapy

(2010) Michael Frezza et al.   CURRENT PHARMACEUTICAL DESIGN

Benzothiazole- and Benzoxazole-Substituted Pyridine-2-Carboxylates as Efficient Sensitizers of Europium Luminescence

(2009) Nail M. Shavaleev et al.   INORGANIC CHEMISTRY