Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1255, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2022.132458
Keywords
Schiff-base; Nickel complex; Copper complex; Crystal structure; Cytoxicity studies
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Funding
- Natural Science Founda-tion of Bengbu Medical University [BYTM2019001]
- Key Natural Science Research Foundation for the University of An-hui [KJ2021ZD0079]
- National University Student Innovation and Entrepreneurship Training Project [201710367031]
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Two metal-organic complexes were synthesized and characterized, and their cytotoxicity and apoptosis properties were investigated.
Two metal-organic complexes of [CuLCl] (1), and [Ni2L2(C2H5OH)(2)Cl-2]center dot 2(C2H5OH)(2)(2) (HL= 2-hydroxy-1-naphthaldehyde-4-aminoantipyrine) were solvothermally synthesized from Schiff-base ligands. Single-crystal X-ray diffraction analysis shows that the mononuclear complex 1 is monoclinic while the dinuclear complex 2 belongs to triclinic crystal structure and the two complexes are both monomer molecules. Additionally, the cancer cytotoxicity, cell migration, and apoptosis properties of both complexes have been investigated. Owing to different coordination behavior between Ni(II) and Cu(II), it was found that com-plex 1 obviously displayed cytotoxicity and decreased cell migration rate by inducing apoptosis of SMMC-7721 cells (hepatoma carcinoma cells). (c) 2022 Published by Elsevier B.V.
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