Journal
NANOMEDICINE
Volume 11, Issue 14, Pages 1817-1830Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/nnm-2016-0086
Keywords
aquaporins; colon cancer; Cuphen; cytotoxic effect; in vivo toxicity studies; liposomes; melanoma; metallodrugs
Funding
- EU COST action [CM1106]
- iMed.ULisboa from Fundacao para a Ciencia e a Tecnologia (FCT), Portugal [UID/DTP/04138/2013]
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Aim: Development of liposomal formulations of Cuphen, a potent copper-based aquaporin inhibitor with therapeutic potential against melanoma and colon cancer. Materials & methods: Cuphen was incorporated into liposomes using the dehydration-rehydration method. The ability of Cuphen to induce cancer cell death was evaluated by MTS and ViaCount assays. In vivo toxicity studies were performed in BALB/c mice. Results: In vitro studies illustrated the antiproliferative effects of Cuphen in different cancer cell lines, in free form or after incorporation into liposomes. In vivo studies revealed no toxic effects after parenteral administration of Cuphen liposomes. Conclusions: Cuphen liposomes are highly attractive to be further tested in murine models due to the possibility of stabilizing and specifically deliver this metallodrug to tumor sites.
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