Journal
PHARMACEUTICS
Volume 10, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics10040216
Keywords
Plectranthus ecklonii; Parvifloron D; cytotoxicity; pancreatic cancer; nanoparticles
Categories
Funding
- Fundacao para a Ciencia e Tecnologia (FCT), through FCT/MEC National funds [UID/AMB/50017]
- FEDER
- FEDER, within Compete 2020
- Fundacao para a Ciencia e Tecnologia (FCT) [UID/DTP/04567/2016]
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Pancreatic cancer is the eighth leading cause of cancer death worldwide. For this reason, the development of more effective therapies is a major concern for the scientific community. Accordingly, plants belonging to Plectranthus genus and their isolated compounds, such as Parvifloron D, were found to have cytotoxic and antiproliferative activities. However, Parvifloron D is a very low water-soluble compound. Thus, nanotechnology can be a promising delivery system to enhance drug solubility and targeted delivery. The extraction of Parvifloron D from P. ecklonii was optimized through an acetone ultrasound-assisted method and isolated by Flash-Dry Column Chromatography. Then, its antiproliferative effect was selectivity evaluated against different cell lines (IC50 of 0.15 +/- 0.05 mu M, 11.9 +/- 0.7 mu M, 21.6 +/- 0.5, 34.3 +/- 4.1 mu M,35.1 +/- 2.2 mu M and 32.1 +/- 4.3 mu M for BxPC3, PANC-1, Ins1-E, MCF-7, HaCat and Caco-2, respectively). To obtain an optimized stable Parvifloron D pharmaceutical dosage form, albumin nanoparticles were produced through a desolvation method (yield of encapsulation of 91.2%) and characterized in terms of size (165 nm; PI 0.11), zeta potential (-7.88 mV) and morphology. In conclusion, Parvifloron D can be efficiently obtained from P. ecklonii and it has shown selective cytotoxicity to pancreatic cell lines. Parvifloron D nanoencapsulation can be considered as a possible efficient alternative approach in the treatment of pancreatic cancer.
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