Instability Challenges and Stabilization Strategies of Pharmaceutical Proteins

Monoclonal Antibodies in Acute Myeloid Leukemia—Are We There Yet?

(2022) Yasmin Abaza et al.   CANCER JOURNAL

A novel method for the chaperone aided and efficient production of human proinsulin in the prokaryotic system

(2022) Fatemeh Khosravi et al.   JOURNAL OF BIOTECHNOLOGY

Investigation of Immune Responses to Oxidation, Deamidation, And Isomerization in Therapeutic Antibodies using Preclinical Immunogenicity Risk Assessment Assays

(2022) Rachel Zeunik et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Nanoparticles for Coronavirus Control

(2022) Maryam Kianpour et al.   Nanomaterials

Characterization of glycosylation in monoclonal antibodies and its importance in therapeutic antibody development

(2021) Harleen Kaur   CRITICAL REVIEWS IN BIOTECHNOLOGY

Protein Unfolding and Aggregation near a Hydrophobic Interface

(2021) David March et al.   Polymers

Stability of Antibody Drug Conjugate Formulations Evaluated Using Solid-State Hydrogen-Deuterium Exchange Mass Spectrometry

(2021) Eunbi Cho et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Site-Specific Lipidation Enhances IFITM3 Membrane Interactions and Antiviral Activity

(2021) Emma H. Garst et al.   ACS Chemical Biology

Voclosporin: First Approval

(2021) Young-A Heo   DRUGS

Antibody‒drug conjugates: Recent advances in linker chemistry

(2021) Zheng Su et al.   Acta Pharmaceutica Sinica B

The Chemistry Behind ADCs

(2021) Vesela Kostova et al.   Pharmaceuticals

Insulin therapy; a valuable legacy and its future perspective

(2021) Mohsen Akbarian   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Alisporivir Improves Mitochondrial Function in Skeletal Muscle of mdx Mice but Suppresses Mitochondrial Dynamics and Biogenesis

(2021) Mikhail V. Dubinin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Current approaches for the purification of antibody–drug conjugates

(2021) Yutaka Matsuda   JOURNAL OF SEPARATION SCIENCE

Aggregation of hen egg white proteins with additives during agitation

(2021) Taehun Hong et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Packing in the proteins

(2021) Colette Whitfield   Nature Reviews Chemistry

Variable-Temperature Native Mass Spectrometry for Studies of Protein Folding, Stabilities, Assembly, and Molecular Interactions

(2021) Arthur Laganowsky et al.   Annual Review of Biophysics

Applications of capillary electrophoresis for biopharmaceutical product characterization

(2021) Ramesh Kumar et al.   ELECTROPHORESIS

Selective and predicable amine conjugation sites by kinetic characterization under excess reagents

(2021) Wei-Chun Huang et al.   Scientific Reports

The effect of lipidation and glycosylation on short cationic antimicrobial peptides

(2020) Elizabeth Grimsey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Biodistribution and pharmacokinetics of thiolated chitosan nanoparticles for oral delivery of insulin in vivo

(2020) Sekar Sudhakar et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Glass Leachables as a Nucleation Factor for Free Fatty Acid Particle Formation in Biopharmaceutical Formulations

(2020) Andrea Allmendinger et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Characterization of Aggregated Antibody-Silicone Oil Complexs; From Perspectives of Morphology, 3D Image, and Fcγ Receptor Activation

(2020) Masato Kiyoshi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Therapeutic Fc‐fusion proteins: Current analytical strategies

(2020) Bastiaan L. Duivelshof et al.   JOURNAL OF SEPARATION SCIENCE

Antibody–Drug Conjugates: The Last Decade

(2020) Nicolas Joubert et al.   Pharmaceuticals

Development of syringes and vials for delivery of biologics: current challenges and innovative solutions

(2020) Saki Yoneda et al.   Expert Opinion on Drug Delivery

Instability of therapeutic proteins — An overview of stresses, stabilization mechanisms and analytical techniques involved in lyophilized proteins

(2020) Arun Butreddy et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Complete mapping of disulfide linkages for etanercept products by multi-enzyme digestion coupled with LC-MS/MS using multi-fragmentations including CID and ETD

(2019) Li-Juan Huang et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

All wrapped up: Stabilization of enzymes within single enzyme nanoparticles

(2019) Robert Chapman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Current strategies in extending half-lives of therapeutic proteins

(2019) Rahela Zaman et al.   JOURNAL OF CONTROLLED RELEASE

The Cold Thermal Response of an Amyloid Oligomer Differs from Typical Globular Protein Cold Denaturation

(2019) Sneha Menon et al.   Journal of Physical Chemistry Letters

Advances in liquid formulations of parenteral therapeutic proteins

(2019) Robert J. Falconer   BIOTECHNOLOGY ADVANCES

Antibody-drug conjugates- stability and formulation

(2019) Corinna Duerr et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Modulating insulin fibrillation using engineered B-chains with mutated C-termini

(2019) Mohsen Akbarian et al.   BIOPHYSICAL JOURNAL

Quality attributes and evaluation of pharmaceutical glass containers for parenterals

(2019) Charudharshini Srinivasan et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Proteolysis and Oxidation of Therapeutic Proteins After Intradermal or Subcutaneous Administration

(2019) Ninad Varkhede et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibody–drug conjugates for cancer

(2019) Cindy H Chau et al.   LANCET

Multi-Attribute Method for Quality Control of Therapeutic Proteins

(2019) Sarah Rogstad et al.   ANALYTICAL CHEMISTRY

Chitosan-Coated Mesoporous Silica Nanoparticle Treatment of Citrullus lanatus (Watermelon): Enhanced Fungal Disease Suppression and Modulated Expression of Stress-Related Genes

(2019) Joseph T. Buchman et al.   ACS Sustainable Chemistry & Engineering

Influence of PEGylation on Domain Dynamics of Phosphoglycerate Kinase: PEG Acts Like Entropic Spring for the Protein

(2018) Karol Ciepluch et al.   BIOCONJUGATE CHEMISTRY

Challenges and opportunities in biopharmaceutical manufacturing control

(2018) Moo Sun Hong et al.   COMPUTERS & CHEMICAL ENGINEERING

Continuous integrated manufacturing of therapeutic proteins

(2018) Daniel Johannes Karst et al.   CURRENT OPINION IN BIOTECHNOLOGY

Excipients in parenteral formulations: selection considerations and effective utilization with small molecules and biologics

(2018) Bindhu Madhavi Rayaprolu et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

In situ mucoadhesive-thermosensitive liposomal gel as a novel vehicle for nasal extended delivery of opiorphin

(2018) Paola Mura et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Chemical modifications of insulin: Finding a compromise between stability and pharmaceutical performance

(2018) Mohsen Akbarian et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Bioorthogonal strategies for site-directed decoration of biomaterials with therapeutic proteins

(2018) Alexandra C. Braun et al.   JOURNAL OF CONTROLLED RELEASE

Stability assessment of antibody-drug conjugate Trastuzumab emtansine in comparison to parent monoclonal antibody using orthogonal testing protocol

(2018) Hoda E. Mohamed et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials

(2018) Dominique Ditter et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Challenges and new frontiers in analytical characterization of antibody-drug conjugates

(2018) Anil Wagh et al.   mAbs

Recent insights in the use of nanocarriers for the oral delivery of bioactive proteins and peptides

(2018) Patrícia Batista et al.   PEPTIDES

Continuous Manufacturing in Pharmaceutical Process Development and Manufacturing

(2018) Christopher L. Burcham et al.   Annual Review of Chemical and Biomolecular Engineering

Dynamic analysis of the interactions between Si/SiO2 quantum dots and biomolecules for improving applications based on nano-bio interfaces

(2018) Miruna Silvia Stan et al.   Scientific Reports

Natural Cyclic Peptides as an Attractive Modality for Therapeutics: A Mini Review

(2018) Muna Abdalla et al.   MOLECULES

Human αB-crystallin as fusion protein and molecular chaperone increases the expression and folding efficiency of recombinant insulin

(2018) Mohsen Akbarian et al.   PLoS One

Drying Technologies for the Stability and Bioavailability of Biopharmaceuticals

(2018) Fakhrossadat Emami et al.   Pharmaceutics

Current trends in protein acetylation analysis

(2018) Issa Diallo et al.   Expert Review of Proteomics

Oxidation-Induced Destabilization of Model Antibody-Drug Conjugates

(2018) Jakob W. Buecheler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Polymer–drug conjugate therapeutics: advances, insights and prospects

(2018) Iriny Ekladious et al.   NATURE REVIEWS DRUG DISCOVERY

Strategies to enhance productivity and modify product quality in therapeutic proteins

(2018) Devesh Radhakrishnan et al.   Current Opinion in Chemical Engineering

Biopolymer-coated nanoliposomes as carriers of rainbow trout skin-derived antioxidant peptides

(2017) Leila Ramezanzade et al.   FOOD CHEMISTRY

Development of coated liposomes loaded with ghrelin for nose-to-brain delivery for the treatment of cachexia

(2017) Laurent Salade et al.   International Journal of Nanomedicine

Dendrimer-conjugated peptide vaccine enhances clearance of Chlamydia trachomatis genital infection

(2017) Ingrid S. Ganda et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Rakicidin F, a new antibacterial cyclic depsipeptide from a marine sponge-derived Streptomyces sp.

(2017) Shigeru Kitani et al.   JOURNAL OF ANTIBIOTICS

A nano-liposome vaccine carrying E75, a HER-2/neu-derived peptide, exhibits significant antitumour activity in mice

(2017) Atefeh Arab et al.   JOURNAL OF DRUG TARGETING

Synergistic Effect of Cavitation and Agitation on Protein Aggregation

(2017) Tetsuo Torisu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Targeting the N terminus for site-selective protein modification

(2017) Christian B Rosen et al.   Nature Chemical Biology

Carboxymethyl-β-cyclodextrin grafted chitosan nanoparticles as oral delivery carrier of protein drugs

(2017) Mingming Song et al.   REACTIVE & FUNCTIONAL POLYMERS

Characterization and QC of biopharmaceuticals by MS-based ‘multi-attribute method’: advantages and challenges

(2017) Yun Zhang et al.   Bioanalysis

Plitidepsin: design, development, and potential place in therapy

(2017) Sara Alonso-Álvarez et al.   Drug Design Development and Therapy

Efficient Eradication of Established Tumors in Mice with Cationic Liposome-Based Synthetic Long-Peptide Vaccines

(2017) Eleni Maria Varypataki et al.   Cancer Immunology Research

Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis – Tandem mass spectrometry as nanoESI infusion platform and separation method

(2016) Nassur Said et al.   ANALYTICA CHIMICA ACTA

A novel approach for oxidation analysis of therapeutic proteins

(2016) Iva Turyan et al.   ANALYTICAL BIOCHEMISTRY

Two-Dimensional Liquid Chromatography: A State of the Art Tutorial

(2016) Dwight R. Stoll et al.   ANALYTICAL CHEMISTRY

Site-Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome

(2016) Seah Ling Kuan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Cellular proteostasis: degradation of misfolded proteins by lysosomes

(2016) M. P. Jackson et al.   Essays in Biochemistry

Physicochemical characterization of biopharmaceuticals

(2016) Maria Kristina Parr et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Physical and Chemical Stability of Antibody Drug Conjugates: Current Status

(2016) Philip L. Ross et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Immunogenicity of Therapeutic Protein Aggregates

(2016) Ehab M. Moussa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Hofmeister Anion Effects on Protein Adsorption at an Air–Water Interface

(2016) Yohko F. Yano et al.   LANGMUIR

Recent advances in mass spectrometric analysis of protein deamidation

(2016) Piliang Hao et al.   MASS SPECTROMETRY REVIEWS

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Antibody-drug conjugates: recent advances in conjugation and linker chemistries

(2016) Kyoji Tsuchikama et al.   Protein & Cell

Structural Studies of a Lipid-Binding Peptide from Tunicate Hemocytes with Anti-Biofilm Activity

(2016) Osmar N. Silva et al.   Scientific Reports

Fusion Proteins for Half-Life Extension of Biologics as a Strategy to Make Biobetters

(2015) William R. Strohl   BIODRUGS

Comparison of Heat-Induced Aggregation of Globular Proteins

(2015) Roy J. B. M. Delahaije et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Unfolding and aggregation of monoclonal antibodies on cation exchange columns: Effects of resin type, load buffer, and protein stability

(2015) Jing Guo et al.   JOURNAL OF CHROMATOGRAPHY A

Cyclic Colisporifungin and Linear Cavinafungins, Antifungal Lipopeptides Isolated from Colispora cavincola

(2015) Francisco Javier Ortíz-López et al.   JOURNAL OF NATURAL PRODUCTS

Do Not Drop: Mechanical Shock in Vials Causes Cavitation, Protein Aggregation, and Particle Formation

(2015) Theodore W. Randolph et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Photoinduced Aggregation of a Model Antibody–Drug Conjugate

(2015) Gregory M. Cockrell et al.   MOLECULAR PHARMACEUTICS

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Photo-Induced Modification of Food Protein Structure and Functionality

(2015) Lara Manzocco   Food Engineering Reviews

Antibody-Drug Conjugates: An Emerging Concept in Cancer Therapy

(2014) Ravi V. J. Chari et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modest Effects of Lipid Modifications on the Structure of Caveolin-3

(2014) Ji-Hun Kim et al.   BIOCHEMISTRY

Chitosan-modified porous silicon microparticles for enhanced permeability of insulin across intestinal cell monolayers

(2014) Neha Shrestha et al.   BIOMATERIALS

Advances in radical probe mass spectrometry for protein footprinting in chemical biology applications

(2014) Simin D. Maleknia et al.   CHEMICAL SOCIETY REVIEWS

Lumazine Peptides Penilumamides B–D and the Cyclic Pentapeptide Asperpeptide A from a Gorgonian-Derived Aspergillus sp. Fungus

(2014) Min Chen et al.   JOURNAL OF NATURAL PRODUCTS

Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation

(2014) Emma M. Pelegri-O’Day et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Theonellamide G, a Potent Antifungal and Cytotoxic Bicyclic Glycopeptide from the Red Sea Marine Sponge Theonella swinhoei

(2014) Diaa Youssef et al.   Marine Drugs

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development of a Cell-Based Assay Measuring the Activation of FcγRIIa for the Characterization of Therapeutic Monoclonal Antibodies

(2014) Minoru Tada et al.   PLoS One

H-Ras forms dimers on membrane surfaces via a protein-protein interface

(2014) W.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cow’s Milk Allergenicity

(2014) Sophia Tsabouri et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Short PEG-Linkers Improve the Performance of Targeted, Activatable Monoclonal Antibody-Indocyanine Green Optical Imaging Probes

(2013) Kohei Sano et al.   BIOCONJUGATE CHEMISTRY

A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia

(2013) S. H. Petersdorf et al.   BLOOD

Antibody–drug conjugates: current status and future directions

(2013) Heidi L. Perez et al.   DRUG DISCOVERY TODAY

Maillard-Reaction-Induced Modification and Aggregation of Proteins and Hardening of Texture in Protein Bar Model Systems

(2013) Peng Zhou et al.   JOURNAL OF FOOD SCIENCE

Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein

(2013) Yizhi Qi et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Oxidation of Therapeutic Proteins and Peptides: Structural and Biological Consequences

(2013) Riccardo Torosantucci et al.   PHARMACEUTICAL RESEARCH

A Human Anti-c-Met Fab Fragment Conjugated with Doxorubicin as Targeted Chemotherapy for Hepatocellular Carcinoma

(2013) Ximin Chen et al.   PLoS One

Analytical approaches to assess the degradation of therapeutic proteins

(2013) Vasco Filipe et al.   TRAC-TRENDS IN ANALYTICAL CHEMISTRY

Building better drugs: developing and regulating engineered therapeutic proteins

(2013) Chava Kimchi-Sarfaty et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Effect of Nanoparticle Size, Shape, and Surface Chemistry on Biological Systems

(2012) Alexandre Albanese et al.   Annual Review of Biomedical Engineering

Converting Peptides into Drug Leads by Lipidation

(2012) L. Zhang et al.   CURRENT MEDICINAL CHEMISTRY

Salt-Induced Aggregation of a Monoclonal Human Immunoglobulin G1

(2012) Jonathan Rubin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Photoinduced Reactivity of Doxorubicin: Catalysis and Degradation

(2012) Krzysztof Nawara et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Disulfide bond structures of IgG molecules

(2012) Hongcheng Liu et al.   mAbs

Pasireotide

(2012) Richard A. Feelders et al.   NATURE REVIEWS DRUG DISCOVERY

Shaking and stirring: Comparison of controlled laboratory stress conditions applied to the human growth hormone

(2012) Johanna Wiesbauer et al.   PROCESS BIOCHEMISTRY

Trastuzumab Emtansine: A Unique Antibody-Drug Conjugate in Development for Human Epidermal Growth Factor Receptor 2-Positive Cancer

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Romidepsin: a novel histone deacetylase inhibitor for cancer

(2011) Erin M Bertino et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma

(2011) Karen M VanderMolen et al.   JOURNAL OF ANTIBIOTICS

Particles in Therapeutic Protein Formulations, Part 1: Overview of Analytical Methods

(2011) Sarah Zölls et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

A Molecular Mechanism of Hydrolysis of Peptide Bonds at Neutral pH Using a Model Compound

(2011) Bin Pan et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Analytical methods for physicochemical characterization of antibody drug conjugates

(2011) Aditya Wakankar et al.   mAbs

Choosing an effective protein bioconjugation strategy

(2011) Nicholas Stephanopoulos et al.   Nature Chemical Biology

Photo-oxidation of proteins

(2011) David I. Pattison et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Chitosan-coated solid lipid nanoparticles enhance the oral absorption of insulin

(2011) Pedro Fonte et al.   Drug Delivery and Translational Research

Ranking the Susceptibility of Disulfide Bonds in Human IgG1 Antibodies by Reduction, Differential Alkylation, and LC−MS Analysis

(2010) Hongcheng Liu et al.   ANALYTICAL CHEMISTRY

Prevention of Stirring-Induced Microparticle Formation in Monoclonal Antibody Solutions

(2010) Tomoyoshi Ishikawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Protein aggregation—Pathways and influencing factors

(2010) Wei Wang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Ziconotide for treatment of severe chronic pain

(2010) Achim Schmidtko et al.   LANCET

Liraglutide

(2010) Daniel J. Drucker et al.   NATURE REVIEWS DRUG DISCOVERY

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

(2010) Anas Younes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Antibody−Drug Conjugates: Linking Cytotoxic Payloads to Monoclonal Antibodies

(2009) Laurent Ducry et al.   BIOCONJUGATE CHEMISTRY

Factors influencing antibody stability at solid-liquid interfaces in a high shear environment

(2009) James G. Biddlecombe et al.   BIOTECHNOLOGY PROGRESS

Human IgG1 Hinge Fragmentation as the Result of H2O2-mediated Radical Cleavage

(2009) Boxu Yan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effect of sucrose hydrolysis on the stability of protein therapeutics during accelerated formulation studies

(2009) Douglas D. Banks et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Quantitative and Qualitative Evaluation of Adsorption/Desorption of Bovine Serum Albumin on Hydrophilic and Hydrophobic Surfaces

(2009) Y. L. Jeyachandran et al.   LANGMUIR

Impact of methionine oxidation on the binding of human IgG1 to FcRn and Fcγ receptors

(2009) Andrea Bertolotti-Ciarlet et al.   MOLECULAR IMMUNOLOGY

Shear flow promotes amyloid-  fibrilization

(2009) D. E. Dunstan et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Shape and evolution of thermostable protein structure

(2009) Ryan G. Coleman et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Cold- and Pressure-Induced Dissociation of Protein Aggregates and Amyloid Fibrils

(2008) Rajesh Mishra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy

(2008) Jong-Ho Kim et al.   BIOMATERIALS

Formulations for delivery of therapeutic proteins

(2008) Snjezana Stolnik et al.   BIOTECHNOLOGY LETTERS

Adsorption and function of recombinant factor VIII at solid–water interfaces in the presence of Tween-80

(2008) Omkar Joshi et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Shaken, Not Stirred: Mechanical Stress Testing of an IgG1 Antibody

(2008) Sylvia Kiese et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein aggregation: Pathways, induction factors and analysis

(2008) Hanns-Christian Mahler et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

How Does Shear Affect Aβ Fibrillogenesis?

(2008) Paul Hamilton-Brown et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Driving Force Behind Adsorption-Induced Protein Unfolding: A Time-Resolved X-ray Reflectivity Study on Lysozyme Adsorbed at an Air/Water Interface

(2008) Yohko F. Yano et al.   LANGMUIR

Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin

(2008) Takumi Takata et al.   PROTEIN SCIENCE