ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes

Distinct differences in the responses of the human pancreatic β-cell line EndoC-βH1 and human islets to proinflammatory cytokines

(2015) Bryndon J. Oleson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

(2015) F Walter et al.   CELL DEATH AND DIFFERENTIATION

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

(2015) Flora Brozzi et al.   DIABETOLOGIA

Proteostasis control by the unfolded protein response

(2015) Claudio Hetz et al.   NATURE CELL BIOLOGY

The IRE1α/XBP1s Pathway Is Essential for the Glucose Response and Protection of β Cells

(2015) Justin R. Hassler et al.   PLOS BIOLOGY

BACH2, a Candidate Risk Gene for Type 1 Diabetes, Regulates Apoptosis in Pancreatic  -Cells via JNK1 Modulation and Crosstalk With the Candidate Gene PTPN2

(2014) L. Marroqui et al.   DIABETES

A Combined “Omics” Approach Identifies N-Myc Interactor as a Novel Cytokine-induced Regulator of IRE1α Protein and c-Jun N-terminal Kinase in Pancreatic Beta Cells

(2014) Flora Brozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Disulfide Isomerase A6 Controls the Decay of IRE1α Signaling via Disulfide-Dependent Association

(2014) Davide Eletto et al.   MOLECULAR CELL

Interplay Between the Oxidoreductase PDIA6 and microRNA-322 Controls the Response to Disrupted Endoplasmic Reticulum Calcium Homeostasis

(2014) J. Groenendyk et al.   Science Signaling

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lipotoxic endoplasmic reticulum stress, β cell failure, and type 2 diabetes mellitus

(2014) Trevor J. Biden et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

A perspective on mammalian upstream open reading frame function

(2013) Joanna Somers et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Stress-Independent Activation of XBP1s and/or ATF6 Reveals Three Functionally Diverse ER Proteostasis Environments

(2013) Matthew D. Shoulders et al.   Cell Reports

tRNA Methyltransferase Homolog Gene TRMT10A Mutation in Young Onset Diabetes and Primary Microcephaly in Humans

(2013) Mariana Igoillo-Esteve et al.   PLoS Genetics

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

(2012) Miriam Cnop et al.   ANNALS OF NEUROLOGY

C/EBP homologous protein contributes to cytokine-induced pro-inflammatory responses and apoptosis in β-cells

(2012) F Allagnat et al.   CELL DEATH AND DIFFERENTIATION

Islet  -Cell Endoplasmic Reticulum Stress Precedes the Onset of Type 1 Diabetes in the Nonobese Diabetic Mouse Model

(2012) S. A. Tersey et al.   DIABETES

Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2012) D. L. Eizirik et al.   DIABETOLOGIA

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α

(2012) Diego A Rodriguez et al.   EMBO JOURNAL

Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells

(2011) J. Y. Chan et al.   DIABETOLOGIA

A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion

(2011) Philippe Ravassard et al.   JOURNAL OF CLINICAL INVESTIGATION

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Modulating stress responses by the UPRosome: A matter of life and death

(2011) Ute Woehlbier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Bcl-2 proteins in diabetes: mitochondrial pathways of β-cell death and dysfunction

(2011) Esteban N. Gurzov et al.   TRENDS IN CELL BIOLOGY

Endoplasmic reticulum stress, obesity and diabetes

(2011) Miriam Cnop et al.   TRENDS IN MOLECULAR MEDICINE

A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1  Activation in Pancreatic   Cells

(2010) Y. Qiu et al.   Science Signaling

ER Stress in Pancreatic   Cells: The Thin Red Line Between Adaptation and Failure

(2010) D. L. Eizirik et al.   Science Signaling

Lectin chaperones help direct the maturation of glycoproteins in the endoplasmic reticulum

(2009) Bradley R. Pearse et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Signaling by IL-1β+IFN-γ and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic β-cell apoptosis

(2009) E N Gurzov et al.   CELL DEATH AND DIFFERENTIATION

ATF4, an ER Stress and Hypoxia-Inducible Transcription Factor and its Potential Role in Hypoxia Tolerance and Tumorigenesis

(2009) Jiangbin Ye et al.   CURRENT MOLECULAR MEDICINE

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

The Role for Endoplasmic Reticulum Stress in Diabetes Mellitus

(2008) Décio L. Eizirik et al.   ENDOCRINE REVIEWS