Inhibition of complement activation by CD55 overexpression in human induced pluripotent stem cell derived kidney organoids

First clinical‐grade porcine kidney xenotransplant using a human decedent model

(2022) Paige M. Porrett et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation

(2022) Robert A. Montgomery et al.   NEW ENGLAND JOURNAL OF MEDICINE

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

(2021) Robin Schmitz et al.   Nature Communications

Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components

(2020) Ignazio Maggio et al.   GENE THERAPY

Ischemia and Reperfusion Injury in Kidney Transplantation: Relevant Mechanisms in Injury and Repair

(2020) Gertrude J. Nieuwenhuijs-Moeke et al.   Journal of Clinical Medicine

Improved production of GTKO/hCD55/hCD59 triple-gene-modified Diannan miniature pigs for xenotransplantation by recloning

(2020) Heng Zhao et al.   TRANSGENIC RESEARCH

Progress in multiple genetically modified minipigs for xenotransplantation in China

(2019) Dengke Pan et al.   XENOTRANSPLANTATION

Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipients

(2019) Tobias Deuse et al.   NATURE BIOTECHNOLOGY

Targeted Disruption of HLA Genes via CRISPR-Cas9 Generates iPSCs with Enhanced Immune Compatibility

(2019) Huaigeng Xu et al.   Cell Stem Cell

Generation of hypoimmunogenic human pluripotent stem cells

(2019) Xiao Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of GTKO Diannan Miniature Pig Expressing Human Complementary Regulator Proteins hCD55 and hCD59 via T2A Peptide-Based Bicistronic Vectors and SCNT

(2018) Fengjuan Liu et al.   MOLECULAR BIOTECHNOLOGY

Complement-activating donor-specific anti-HLA antibodies and solid organ transplant survival: A systematic review and meta-analysis

(2018) Antoine Bouquegneau et al.   PLOS MEDICINE

Generation of Functioning Nephrons by Implanting Human Pluripotent Stem Cell-Derived Kidney Progenitors

(2018) Ioannis Bantounas et al.   Stem Cell Reports

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

(2018) Cathelijne W. van den Berg et al.   Stem Cell Reports

Beyond the Role of CD55 as a Complement Component

(2018) So Hee Dho et al.   Immune Network

Overexpression of Human CD55 and CD59 or Treatment with Human CD55 Protects against Renal Ischemia-Reperfusion Injury in Mice

(2017) Anjan K. Bongoni et al.   JOURNAL OF IMMUNOLOGY

HLA-E-expressing pluripotent stem cells escape allogeneic responses and lysis by NK cells

(2017) Germán G Gornalusse et al.   NATURE BIOTECHNOLOGY

The renaissance of complement therapeutics

(2017) Daniel Ricklin et al.   Nature Reviews Nephrology

Immunogenicity of human embryonic stem cell-derived beta cells

(2016) Cornelis R. van der Torren et al.   DIABETOLOGIA

Probing the impact of chromatin conformation on genome editing tools

(2016) Xiaoyu Chen et al.   NUCLEIC ACIDS RESEARCH

Molecules Great and Small: The Complement System

(2015) D. R. Mathern et al.   Clinical Journal of the American Society of Nephrology

Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation

(2015) S. Sharmin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Ex Vivo Expanded Human Regulatory T Cells Delay Islet Allograft Rejection via Inhibiting Islet-Derived Monocyte Chemoattractant Protein-1 Production in CD34+ Stem Cells-Reconstituted NOD-scid IL2rγnull Mice

(2014) Fang Xiao et al.   PLoS One

Complement-Binding Anti-HLA Antibodies and Kidney-Allograft Survival

(2013) Alexandre Loupy et al.   NEW ENGLAND JOURNAL OF MEDICINE

C3a and C5a Promote Renal Ischemia-Reperfusion Injury

(2012) Q. Peng et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Expression of the Decay-Accelerating Factor (CD55) in Renal Transplants—A Possible Prediction Marker of Allograft Survival

(2009) Sergey V. Brodsky et al.   TRANSPLANTATION

Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis

(2008) P. N. Lalli et al.   BLOOD

Complement 5a Receptor Inhibition Improves Renal Allograft Survival

(2008) F. Gueler et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute Antibody-Mediated Complement Activation Mediates Lysis of Pancreatic Islets Cells and May Cause Tissue Loss in Clinical Islet Transplantation

(2008) Jenny Tjernberg et al.   TRANSPLANTATION

Robust, Persistent Transgene Expression in Human Embryonic Stem Cells Is Achieved with AAVS1-Targeted Integration

(2007) Joseph R. Smith et al.   STEM CELLS