Replication Stress in Mammalian Cells and Its Consequences for Mitosis

Polo-like kinase 1 inhibits DNA damage response during mitosis

(2015) Jan Benada et al.   CELL CYCLE

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress

(2015) Yu-Hung Chen et al.   MOLECULAR CELL

The SLX4 Complex Is a SUMO E3 Ligase that Impacts on Replication Stress Outcome and Genome Stability

(2015) Jean-Hugues Guervilly et al.   MOLECULAR CELL

MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5′ end resection

(2015) Vera Boersma et al.   NATURE

Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination

(2015) Pedro A. Mateos-Gomez et al.   NATURE

REV7 counteracts DNA double-strand break resection and affects PARP inhibition

(2015) Guotai Xu et al.   NATURE

Nuclear translocation of Cyclin B1 marks the restriction point for terminal cell cycle exit in G2 phase

(2014) Erik Müllers et al.   CELL CYCLE

Updating the mechanisms of common fragile site instability: how to reconcile the different views?

(2014) Benoît Le Tallec et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The origins and processing of ultra fine anaphase DNA bridges

(2014) Ying Liu et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Activation of p53 in G2 Phase Is Sufficient to Induce Senescence

(2014) Lenno Krenning et al.   MOLECULAR CELL

Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks

(2014) Dong-Hyun Lee et al.   MOLECULAR CELL

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

(2014) Helge Gad et al.   NATURE

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

(2014) Johanna Flach et al.   NATURE

RASSF1A–LATS1 signalling stabilizes replication forks by restricting CDK2-mediated phosphorylation of BRCA2

(2014) Dafni-Eleftheria Pefani et al.   NATURE CELL BIOLOGY

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

(2014) François Aymard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATM Alters the Otherwise Robust Chromatin Mobility at Sites of DNA Double-Strand Breaks (DSBs) in Human Cells

(2014) Annabelle Becker et al.   PLoS One

Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions

(2014) A. Orthwein et al.   SCIENCE

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

(2014) Matthew J. Yousefzadeh et al.   PLoS Genetics

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

Is homologous recombination really an error-free process?

(2014) Josée Guirouilh-Barbat et al.   Frontiers in Genetics

Modernizing the Nonhomologous End-Joining Repertoire: Alternative and Classical NHEJ Share the Stage

(2013) Ludovic Deriano et al.   Annual Review of Genetics

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

(2013) Jacqueline H. Barlow et al.   CELL

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

Functions of the centromere and kinetochore in chromosome segregation

(2013) Frederick G Westhorpe et al.   CURRENT OPINION IN CELL BIOLOGY

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells

(2013) R. L. Ragland et al.   GENES & DEVELOPMENT

GC skew at the 5' and 3' ends of human genes links R-loop formation to epigenetic regulation and transcription termination

(2013) P. A. Ginno et al.   GENOME RESEARCH

Role of DNA secondary structures in fragile site breakage along human chromosome 10

(2013) Laura W. Dillon et al.   HUMAN MOLECULAR GENETICS

RIF1 Counteracts BRCA1-mediated End Resection during DNA Repair

(2013) Lin Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New histone supply regulates replication fork speed and PCNA unloading

(2013) Jakob Mejlvang et al.   JOURNAL OF CELL BIOLOGY

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

(2013) Valérie Bergoglio et al.   JOURNAL OF CELL BIOLOGY

Oncogenes induce genotoxic stress by mitotic processing of unusual replication intermediates

(2013) Kai J. Neelsen et al.   JOURNAL OF CELL BIOLOGY

A Cell Cycle-Dependent Regulatory Circuit Composed of 53BP1-RIF1 and BRCA1-CtIP Controls DNA Repair Pathway Choice

(2013) Cristina Escribano-Díaz et al.   MOLECULAR CELL

Replication stress links structural and numerical cancer chromosomal instability

(2013) Rebecca A. Burrell et al.   NATURE

ERCC1 and MUS81–EME1 promote sister chromatid separation by processing late replication intermediates at common fragile sites during mitosis

(2013) Valeria Naim et al.   NATURE CELL BIOLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Transcription-dependent dynamic supercoiling is a short-range genomic force

(2013) Fedor Kouzine et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells

(2013) T. Wilhelm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

53BP1 Regulates DSB Repair Using Rif1 to Control 5' End Resection

(2013) M. Zimmermann et al.   SCIENCE

Spatial Dynamics of Chromosome Translocations in Living Cells

(2013) V. Roukos et al.   SCIENCE

Rif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching

(2013) M. Di Virgilio et al.   SCIENCE

Subdiffusion Supports Joining Of Correct Ends During Repair Of DNA Double-Strand Breaks

(2013) S. Girst et al.   Scientific Reports

A Role for BLM in Double-Strand Break Repair Pathway Choice: Prevention of CtIP/Mre11-Mediated Alternative Nonhomologous End-Joining

(2013) Anastazja Grabarz et al.   Cell Reports

Common Fragile Site Profiling in Epithelial and Erythroid Cells Reveals that Most Recurrent Cancer Deletions Lie in Fragile Sites Hosting Large Genes

(2013) Benoît Le Tallec et al.   Cell Reports

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

(2013) Stéphane Koundrioukoff et al.   PLoS Genetics

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

RTEL1 Dismantles T Loops and Counteracts Telomeric G4-DNA to Maintain Telomere Integrity

(2012) Jean-Baptiste Vannier et al.   CELL

Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes

(2012) Amaya Alzu et al.   CELL

Interference Between DNA Replication and Transcription as a Cause of Genomic Instability

(2012) Yea-Lih Lin et al.   CURRENT GENOMICS

Chromothripsis: Chromosomes in Crisis

(2012) Mathew J.K. Jones et al.   DEVELOPMENTAL CELL

dNTP pools determine fork progression and origin usage under replication stress

(2012) Jérôme Poli et al.   EMBO JOURNAL

A genome-wide analysis of common fragile sites: What features determine chromosomal instability in the human genome?

(2012) Arkarachai Fungtammasan et al.   GENOME RESEARCH

53BP1 deficiency combined with telomere dysfunction activates ATR-dependent DNA damage response

(2012) Paula Martínez et al.   JOURNAL OF CELL BIOLOGY

The RAD51 paralogs ensure cellular protection against mitotic defects and aneuploidy

(2012) Amélie Rodrigue et al.   JOURNAL OF CELL SCIENCE

Chromatin mobility is increased at sites of DNA double-strand breaks

(2012) P. M. Krawczyk et al.   JOURNAL OF CELL SCIENCE

BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair

(2012) J. R. Chapman et al.   JOURNAL OF CELL SCIENCE

DNA breaks and chromosome pulverization from errors in mitosis

(2012) Karen Crasta et al.   NATURE

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures

(2012) Colleen Barefield et al.   NUCLEIC ACIDS RESEARCH

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

(2012) D. McIntosh et al.   Cold Spring Harbor Perspectives in Biology

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

(2012) Joshua C. Saldivar et al.   PLoS Genetics

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

(2011) Joao Matos et al.   CELL

Chromosome Catastrophes Involve Replication Mechanisms Generating Complex Genomic Rearrangements

(2011) Pengfei Liu et al.   CELL

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

(2011) Assaf C. Bester et al.   CELL

Replication stress induces 53BP1-containing OPT domains in G1 cells

(2011) Jeanine A. Harrigan et al.   JOURNAL OF CELL BIOLOGY

Collisions between Replication and Transcription Complexes Cause Common Fragile Site Instability at the Longest Human Genes

(2011) Anne Helmrich et al.   MOLECULAR CELL

Regulation of DNA End Joining, Resection, and Immunoglobulin Class Switch Recombination by 53BP1

(2011) Anne Bothmer et al.   MOLECULAR CELL

Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs

(2011) Luis I. Toledo et al.   Molecular Oncology

Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site

(2011) Anne Letessier et al.   NATURE

53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

(2011) Claudia Lukas et al.   NATURE CELL BIOLOGY

RAD51- and MRE11-dependent reassembly of uncoupled CMG helicase complex at collapsed replication forks

(2011) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular profiling of common fragile sites in human fibroblasts

(2011) Benoî Le Tallec et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

(2011) Xuefeng Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation

(2011) Corentin Laulier et al.   NUCLEIC ACIDS RESEARCH

Surviving chromosome replication: the many roles of the S-phase checkpoint pathway

(2011) K. Labib et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Replication Stress Induces Micronuclei Comprising of Aggregated DNA Double-Strand Breaks

(2011) Bing Xu et al.   PLoS One

Chromosome missegregation in human cells arises through specific types of kinetochore-microtubule attachment errors

(2011) S. L. Thompson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common fragile sites: mechanisms of instability revisited

(2011) Michelle Debatisse et al.   TRENDS IN GENETICS

Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand Breaks

(2011) Petra Langerak et al.   PLoS Genetics

Histone H3K56 Acetylation, CAF1, and Rtt106 Coordinate Nucleosome Assembly and Stability of Advancing Replication Forks

(2011) Marta Clemente-Ruiz et al.   PLoS Genetics

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

(2010) Samuel F. Bunting et al.   CELL

Replication dynamics at common fragile site FRA6E

(2010) Elisa Palumbo et al.   CHROMOSOMA

Programming DNA replication origins and chromosome organization

(2010) Christelle Cayrou et al.   CHROMOSOME RESEARCH

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Cytokinesis failure occurs in Fanconi anemia pathway–deficient murine and human bone marrow hematopoietic cells

(2010) Patrizia Vinciguerra et al.   JOURNAL OF CLINICAL INVESTIGATION

The Bloom Syndrome Protein Limits the Lethality Associated with RAD51 Deficiency

(2010) K. Lahkim Bennani-Belhaj et al.   MOLECULAR CANCER RESEARCH

Homologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template Exchange

(2010) Sarah Lambert et al.   MOLECULAR CELL

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Molecular mechanisms of micronucleus, nucleoplasmic bridge and nuclear bud formation in mammalian and human cells

(2010) M. Fenech et al.   MUTAGENESIS

Genetic activities in micronuclei: Is the DNA entrapped in micronuclei lost for the cell?

(2010) Mariona Terradas et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad21-Cohesin Haploinsufficiency Impedes DNA Repair and Enhances Gastrointestinal Radiosensitivity in Mice

(2010) Huiling Xu et al.   PLoS One

The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis

(2010) M. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

A role for recombination in centromere function

(2010) Ramsay J. McFarlane et al.   TRENDS IN GENETICS

Over half of breakpoints in gene pairs involved in cancer-specific recurrent translocations are mapped to human chromosomal fragile sites

(2009) Allison A Burrow et al.   BMC GENOMICS

Genome-Organizing Factors Top2 and Hmo1 Prevent Chromosome Fragility at Sites of S phase Transcription

(2009) Rodrigo Bermejo et al.   CELL

Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication

(2009) Agnel Sfeir et al.   CELL

Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism

(2009) K. Mizuno et al.   GENES & DEVELOPMENT

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

(2009) P. Martinez et al.   GENES & DEVELOPMENT

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks

(2009) C. E. Bansbach et al.   GENES & DEVELOPMENT

Human CtIP Mediates Cell Cycle Control of DNA End Resection and Double Strand Break Repair

(2009) Pablo Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Rif1 contributes to replication stress survival and homology-directed repair

(2009) Sara B.C. Buonomo et al.   JOURNAL OF CELL BIOLOGY

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

(2009) Sandie Tuduri et al.   NATURE CELL BIOLOGY

Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

(2009) Kok Lung Chan et al.   NATURE CELL BIOLOGY

The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities

(2009) Valeria Naim et al.   NATURE CELL BIOLOGY

The DNA replication FoSTeS/MMBIR mechanism can generate genomic, genic and exonic complex rearrangements in humans

(2009) Feng Zhang et al.   NATURE GENETICS

Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells

(2009) Emilie Rass et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ATR-Chk1 pathway plays a role in the generation of centrosome aberrations induced by Rad51C dysfunction

(2009) M. Katsura et al.   NUCLEIC ACIDS RESEARCH

Sequencing newly replicated DNA reveals widespread plasticity in human replication timing

(2009) R. S. Hansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ReplicationDomain: a visualization tool and comparative database for genome-wide replication timing data

(2008) Nodin Weddington et al.   BMC BIOINFORMATICS

Inhibition of S-phase progression triggered by UVA-induced ROS does not require a functional DNA damage checkpoint response in mammalian cells

(2008) Pierre-Marie Girard et al.   DNA REPAIR

Mus81 is essential for sister chromatid recombination at broken replication forks

(2008) Laura Roseaulin et al.   EMBO JOURNAL

Rad51 suppresses gross chromosomal rearrangement at centromere in Schizosaccharomyces pombe

(2008) Ken-ichi Nakamura et al.   EMBO JOURNAL

Centromere mitotic recombination in mammalian cells

(2008) Isabel Jaco et al.   JOURNAL OF CELL BIOLOGY

A homologous recombination defect affects replication-fork progression in mammalian cells

(2007) F. Daboussi et al.   JOURNAL OF CELL SCIENCE

Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

(2007) T. Boveri   JOURNAL OF CELL SCIENCE

Analysis of centrosome overduplication in correlation to cell division errors in high-risk human papillomavirus (HPV)-associated anal neoplasms

(2007) Anette Duensing et al.   VIROLOGY