Gasdermin D pore-forming activity is redox-sensitive

The lysosomal Ragulator complex activates NLRP3 inflammasome in vivo via HDAC6

(2022) Kohei Tsujimoto et al.   EMBO JOURNAL

Itaconate confers tolerance to late NLRP3 inflammasome activation

(2021) Monika Bambouskova et al.   Cell Reports

The Chemistry of Reactive Oxygen Species (ROS) Revisited: Outlining Their Role in Biological Macromolecules (DNA, Lipids and Proteins) and Induced Pathologies

(2021) Celia Andrés Juan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gasdermin D pore structure reveals preferential release of mature interleukin-1

(2021) Shiyu Xia et al.   NATURE

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

(2021) Charles L. Evavold et al.   CELL

ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation

(2021) Shuhang Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The lysosomal Rag-Ragulator complex licenses RIPK1– and caspase-8–mediated pyroptosis by Yersinia

(2021) Zengzhang Zheng et al.   SCIENCE

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation

(2020) Jun Jacob Hu et al.   NATURE IMMUNOLOGY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Succination inactivates gasdermin D and blocks pyroptosis

(2020) Fiachra Humphries et al.   SCIENCE

Characterization and Optimization of Multiplexed Quantitative Analyses Using High-Field Asymmetric-Waveform Ion Mobility Mass Spectrometry

(2019) Devin K. Schweppe et al.   ANALYTICAL CHEMISTRY

The Gasdermin-D pore acts as a conduit for IL-1β secretion in mice

(2018) Rosalie Heilig et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Cutting Edge: Mitochondrial Assembly of the NLRP3 Inflammasome Complex Is Initiated at Priming

(2018) Eric I. Elliott et al.   JOURNAL OF IMMUNOLOGY

Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death

(2018) Pontus Orning et al.   SCIENCE

Redox sensitivity of the MyD88 immune signaling adapter

(2016) Benjamin Stottmeier et al.   FREE RADICAL BIOLOGY AND MEDICINE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

(2014) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

(2012) Jakob von Moltke et al.   NATURE

Comet: An open-source MS/MS sequence database search tool

(2012) Jimmy K. Eng et al.   PROTEOMICS

TLR signalling augments macrophage bactericidal activity through mitochondrial ROS

(2011) A. Phillip West et al.   NATURE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Reactive oxygen species homeostasis and signalling during drought and salinity stresses

(2009) GAD MILLER et al.   PLANT CELL AND ENVIRONMENT

Monomeric CFTR in Plasma Membranes in Live Cells Revealed by Single Molecule Fluorescence Imaging

(2008) Peter M. Haggie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY