ASC deglutathionylation is a checkpoint for NLRP3 inflammasome activation

Targeting monoamine oxidase to dampen NLRP3 inflammasome activation in inflammation

(2020) Ricardo Sánchez-Rodríguez et al.   Cellular & Molecular Immunology

NLRP3 inflammasome priming: A riddle wrapped in a mystery inside an enigma

(2020) Chloe M. McKee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Glutathione Transferase Omega-1 Regulates NLRP3 Inflammasome Activation through NEK7 Deglutathionylation

(2019) Mark M. Hughes et al.   Cell Reports

Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1

(2018) Yang Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular ATP Activates the NLRP3 Inflammasome and Is an Early Danger Signal of Skin Allograft Rejection

(2017) Joaquín Amores-Iniesta et al.   Cell Reports

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

(2017) Deepthi Menon et al.   Scientific Reports

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Assembly and regulation of ASC specks

(2016) Florian Hoss et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

(2016) Florian I. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ASC filament formation serves as a signal amplification mechanism for inflammasomes

(2016) Mathias S. Dick et al.   Nature Communications

Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis

(2016) I-Che Chung et al.   Scientific Reports

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes

(2014) Alvin Lu et al.   CELL

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome

(2014) Hao Xu et al.   NATURE

A Role for Glutathione Transferase Omega 1 (GSTO1-1) in the Glutathionylation Cycle

(2013) Deepthi Menon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome

(2012) Tae-Bong Kang et al.   IMMUNITY

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

(2012) M. Inoue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

(2011) Yue Zhao et al.   NATURE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome

(2010) C. Bauer et al.   GUT

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

Isolation of mitochondria-associated membranes and mitochondria from animal tissues and cells

(2009) Mariusz R Wieckowski et al.   Nature Protocols

Superoxide dismutase 1 regulates caspase-1 and endotoxic shock

(2008) Felix Meissner et al.   NATURE IMMUNOLOGY