Lymphoid clonal hematopoiesis: implications for malignancy, immunity, and treatment

Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis

(2022) Siddhartha P. Kar et al.   NATURE GENETICS

Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia

(2021) Sofie Lundgren et al.   LEUKEMIA

Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis

(2021) Ryunosuke Saiki et al.   NATURE MEDICINE

Peripheral Blood Single-Cell Genotyping and Phenotyping in Multiple Myeloma Reveals Shared Mutations across Multiple Hematopoietic Cell Lineages

(2021) David G. Coffey et al.   BLOOD

IgM-MM is predominantly a pre–germinal center disorder and has a distinct genomic and transcriptomic signature from WM

(2021) Abdul Hamid Bazarbachi et al.   BLOOD

Tumor-Confirmed Follicular Lymphoma Mutations Are Detectable in Peripheral Blood Years Prior to Clinical Diagnosis

(2021) Joseph G Schroers-Martin et al.   BLOOD

HIGH-RISK SUBTYPES OF CHRONIC LYMPHOCYTIC LEUKEMIA ARE DETECTABLE AS EARLY AS 16 YEARS PRIOR TO DIAGNOSIS

(2021) P. Martijn Martijn Kolijn et al.   BLOOD

Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation

(2021) Christopher J. Gibson et al.   JOURNAL OF CLINICAL ONCOLOGY

Distinction of lymphoid and myeloid clonal hematopoiesis

(2021) Abhishek Niroula et al.   NATURE MEDICINE

CD8+ cell somatic mutations in multiple sclerosis patients and controls—Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies

(2021) Miko Valori et al.   PLoS One

Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity

(2021) Brooke Prinzing et al.   Science Translational Medicine

Understanding Monoclonal B Cell Lymphocytosis: An Interplay of Genetic and Microenvironmental Factors

(2021) Chrysi Galigalidou et al.   Frontiers in Oncology

Clonal hematopoiesis is associated with increased risk of progression of asymptomatic Waldenström macroglobulinemia

(2021) Sabrin Tahri et al.   Blood Advances

Lymphoma Driver Mutations in the Pathogenic Evolution of an Iconic Human Autoantibody

(2020) Mandeep Singh et al.   CELL

Germline TET2 Loss-Of-Function Causes Childhood Immunodeficiency And Lymphoma

(2020) Jarmila Stremenova Spegarova et al.   BLOOD

Chromosomal alterations among age-related haematopoietic clones in Japan

(2020) Chikashi Terao et al.   NATURE

Clonal hematopoiesis is associated with adverse outcomes in multiple myeloma patients undergoing transplant

(2020) Tarek H. Mouhieddine et al.   Nature Communications

Cancer therapy shapes the fitness landscape of clonal hematopoiesis

(2020) Kelly L. Bolton et al.   NATURE GENETICS

Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature

(2020) Tiina Kelkka et al.   Frontiers in Immunology

Association of Immune Marker Changes With Progression of Monoclonal Gammopathy of Undetermined Significance to Multiple Myeloma

(2019) Ola Landgren et al.   JAMA Oncology

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations

(2018) Andreas Agathangelidis et al.   HAEMATOLOGICA

Loss of KLHL6 promotes diffuse large B-cell lymphoma growth and survival by stabilizing the mRNA decay factor roquin2

(2018) Jaewoo Choi et al.   NATURE CELL BIOLOGY

Highly similar genomic landscapes in monoclonal B-cell lymphocytosis and ultra-stable chronic lymphocytic leukemia with low frequency of driver mutations

(2018) Andreas Agathangelidis et al.   HAEMATOLOGICA

Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations

(2018) Po-Ru Loh et al.   NATURE

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

(2018) Joseph A. Fraietta et al.   NATURE

Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation

(2018) Mareike Frick et al.   JOURNAL OF CLINICAL ONCOLOGY

TET2 deficiency causes germinal center hyperplasia, impairs plasma cell differentiation and promotes B-cell lymphomagenesis

(2018) Pilar M Dominguez et al.   Cancer Discovery

Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-Münster protocols

(2017) Marius Rohde et al.   HAEMATOLOGICA

Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma

(2017) Christopher J. Gibson et al.   JOURNAL OF CLINICAL ONCOLOGY

The fate and lifespan of human monocyte subsets in steady state and systemic inflammation

(2017) Amit A. Patel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Loss of TET2 Promotes CD8+T Cell Memory Differentiation

(2017) Shannon A. Carty et al.   JOURNAL OF IMMUNOLOGY

Clonal hematopoiesis

(2017) Max Jan et al.   SEMINARS IN HEMATOLOGY

Relevance of ID3-TCF3-CCND3 pathway mutations in pediatric aggressive B-cell lymphoma treated according to the non-Hodgkin Lymphoma Berlin-Frankfurt-Münster protocols

(2017) Marius Rohde et al.   HAEMATOLOGICA

Human neutrophil kinetics: modeling of stable isotope labeling data supports short blood neutrophil half-lives

(2016) Julio Lahoz-Beneytez et al.   BLOOD

Clonal hematopoiesis in acquired aplastic anemia

(2016) S. Ogawa   BLOOD

Genomic characterization of high-count MBL cases indicates that early detection of driver mutations and subclonal expansion are predictors of adverse clinical outcome

(2016) S Barrio et al.   LEUKEMIA

Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults

(2016) Andrew L. Young et al.   Nature Communications

Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes

(2015) D. P. Steensma et al.   BLOOD

The Methylcytosine Dioxygenase Tet2 Promotes DNA Demethylation and Activation of Cytokine Gene Expression in T Cells

(2015) Kenji Ichiyama et al.   IMMUNITY

Mild B-cell lymphocytosis in patients with a CARD11 C49Y mutation

(2015) David Buchbinder et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Risk of follicular lymphoma associated withBCL2translocations in peripheral blood

(2015) Carsten Hirt et al.   LEUKEMIA & LYMPHOMA

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia

(2015) Tetsuichi Yoshizato et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leukemia-Associated Somatic Mutations Drive Distinct Patterns of Age-Related Clonal Hemopoiesis

(2015) Thomas McKerrell et al.   Cell Reports

Immunologic assessment and KMT2D mutation detection in Kabuki syndrome

(2014) J.-L. Lin et al.   CLINICAL GENETICS

Nature and importance of follicular lymphoma precursors

(2014) E. Mamessier et al.   HAEMATOLOGICA

Germline CARD11 Mutation in a Patient with Severe Congenital B Cell Lymphocytosis

(2014) Andrew S. Brohl et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Age-related mutations associated with clonal hematopoietic expansion and malignancies

(2014) Mingchao Xie et al.   NATURE MEDICINE

Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence

(2014) Giulio Genovese et al.   NEW ENGLAND JOURNAL OF MEDICINE

Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes

(2014) Siddhartha Jaiswal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of IGH locus breakpoints in multiple myeloma indicates a subset of translocations appear to occur in pregerminal center B cells

(2013) B. A. Walker et al.   BLOOD

Confirmation of the Reported Association of Clonal Chromosomal Mosaicism with an Increased Risk of Incident Hematologic Cancer

(2013) Ursula M. Schick et al.   PLoS One

Recurrent TET2 mutations in peripheral T-cell lymphomas correlate with TFH-like features and adverse clinical parameters

(2012) F. Lemonnier et al.   BLOOD

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

(2012) Lambert Busque et al.   NATURE GENETICS

Recurrent mutation of the ID3 gene in Burkitt lymphoma identified by integrated genome, exome and transcriptome sequencing

(2012)   NATURE GENETICS

Detectable clonal mosaicism and its relationship to aging and cancer

(2012) Kevin B Jacobs et al.   NATURE GENETICS

Detectable clonal mosaicism from birth to old age and its relationship to cancer

(2012) Cathy C Laurie et al.   NATURE GENETICS

Cooperative function of CCR7 and lymphotoxin in the formation of a lymphoma-permissive niche within murine secondary lymphoid organs

(2011) A. Rehm et al.   BLOOD

General population low-count CLL-like MBL persists over time without clinical progression, although carrying the same cytogenetic abnormalities of CLL

(2011) C. Fazi et al.   BLOOD

TET2 Inactivation Results in Pleiotropic Hematopoietic Abnormalities in Mouse and Is a Recurrent Event during Human Lymphomagenesis

(2011) Cyril Quivoron et al.   CANCER CELL

Self-Renewing Hematopoietic Stem Cell Is the Primary Target in Pathogenesis of Human Chronic Lymphocytic Leukemia

(2011) Yoshikane Kikushige et al.   CANCER CELL

Immunophenotypic and gene expression analysis of monoclonal B-cell lymphocytosis shows biologic characteristics associated with good prognosis CLL

(2011) M C Lanasa et al.   LEUKEMIA

Molecular Ontogeny of Donor-Derived Follicular Lymphomas Occurring after Hematopoietic Cell Transplantation

(2011) Oliver Weigert et al.   Cancer Discovery

Somatic FAS mutations are common in patients with genetically undefined autoimmune lymphoproliferative syndrome

(2010) K. C. Dowdell et al.   BLOOD

Different biology and clinical outcome according to the absolute numbers of clonal B-cells in monoclonal B-cell lymphocytosis (MBL)

(2010) Andy C. Rawstron et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Identification of translocation products but not K-RAS mutations in memory B cells from patients with multiple myeloma

(2010) T. Rasmussen et al.   HAEMATOLOGICA

Onset of autoimmune lymphoproliferative syndrome (ALPS) in humans as a consequence of genetic defect accumulation

(2010) Aude Magerus-Chatinet et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing identifies MLL2 mutations as a cause of Kabuki syndrome

(2010) Sarah B Ng et al.   NATURE GENETICS

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study

(2009) O. Landgren et al.   BLOOD

The prognosis of clinical monoclonal B cell lymphocytosis differs from prognosis of Rai 0 chronic lymphocytic leukaemia and is recapitulated by biological risk factors

(2009) Davide Rossi et al.   BRITISH JOURNAL OF HAEMATOLOGY

t(11;14)-positive clones can persist over a long period of time in the peripheral blood of healthy individuals

(2009) Y Lecluse et al.   LEUKEMIA

Prevalence and frequency of circulating t(14;18)-MBR translocation carrying cells in healthy individuals

(2008) Frank Schüler et al.   INTERNATIONAL JOURNAL OF CANCER

Peripheral blood lymphocytosis–what is the threshold for further investigation?

(2008) Dennis Carney   LEUKEMIA & LYMPHOMA

Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia

(2008) Andy C. Rawstron et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool

(2008) N. Vrisekoop et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA