Review
Genetics & Heredity
Kelly K. Barry, Michaelangelo Tsaparlis, Deborah Hoffman, Deborah Hartman, Margaret P. Adam, Christina Hung, Olaf A. Bodamer
Summary: This review examines the current understanding of Kabuki syndrome, a rare neuro-developmental disorder, and highlights the variability in clinical phenotype and the need for further research on clinical management and patient burden.
Article
Genetics & Heredity
Allison J. Kalinousky, Tyler Rapp, Hadia Hijazi, Jennifer Johnson, Hans Tomas Bjornsson, Jacqueline R. Harris
Summary: The study found that children with KS have significantly higher levels of anxiety and total behavior problems compared to their unaffected siblings. A large proportion of affected individuals exceeded the established threshold for anxiety, indicating that anxiety is a common feature of KS.
FRONTIERS IN GENETICS
(2022)
Article
Multidisciplinary Sciences
Sheng Yi, Xiaofei Zhang, Qi Yang, Jingjing Huang, Xunzhao Zhou, Jiale Qian, Pingshan Pan, Shang Yi, Shujie Zhang, Qiang Zhang, Xianglian Tang, Limei Huang, Qinle Zhang, Zailong Qin, Jingsi Luo
Summary: Kabuki syndrome (KS) is a congenital anomaly syndrome with diverse features. This study describes the clinical characteristics of nine sporadic KS patients, highlighting intellectual disability and short stature as the main features, along with a high prevalence of motor retardation and recurrent otitis media. Whole-exome sequencing identified nine KMT2D variants, including four novel ones. These findings expand the mutation spectrum of KMT2D and provide valuable insights for genetic counseling and treatment optimization.
Article
Oncology
Sarah Jessica Goodman, Teresa Romeo Luperchio, Jacob Ellegood, Eric Chater-Diehl, Jason P. Lerch, Hans Tomas Bjornsson, Rosanna Weksberg
Summary: This study investigates the effect of AR-42 treatment on neuroanatomy and DNA methylation (DNAm) in a mouse model of Kabuki syndrome type 1 (KS1). The findings suggest that AR-42 treatment can improve hippocampal memory deficits in KS1 mice and that blood DNAm may serve as a potential biomarker of disease severity. The study also identifies a DNAm signature in the blood of KS1 mice and shows that AR-42 treatment can ameliorate DNAm aberrations.
CLINICAL EPIGENETICS
(2023)
Article
Pathology
Jyoti Kumar, Amy E. Alspach, Jacob P. Zucker, Dita Gratzinger
Summary: This unique case presentation of a young patient with KS and B-cell lymphoma highlights the potential critical roles of KMT2D and TET2 alterations in promoting lymphomagenesis in this patient.
AMERICAN JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Immunology
Marco Kunzli, David Masopust
Summary: This review provides updates on our understanding of the biology of memory CD4(+) T cells as well as key technological advances that facilitate their characterization.
Article
Immunology
Chang Kyung Kang, Minji Kim, Jisu Hong, Gwanghun Kim, Soojin Lee, Euijin Chang, Pyoeng Gyun Choe, Nam Joong Kim, Ik Soo Kim, Jun-Young Seo, Daesub Song, Dong-Sup Lee, Hyun Mu Shin, Yong-Woo Kim, Chang-Han Lee, Wan Beom Park, Hang-Rae Kim, Myoung-don Oh
Summary: A year after COVID-19, immune responses varied among patients with asymptomatic, mild, and severe illness, with parameters such as phagocytic capacity of antibodies and memory B-cell responses strongly associated with disease severity. These findings could inform tailored vaccination strategies post-natural infection based on COVID-19 severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Michela Ciocca, Salvatore Zaffina, Ane Fernandez Salinas, Chiara Bocci, Patrizia Palomba, Maria Giulia Conti, Sara Terreri, Giuseppe Frisullo, Ezio Giorda, Marco Scarsella, Rita Brugaletta, Maria Rosaria Vinci, Nicola Magnavita, Rita Carsetti, Eva Piano Mortari
Summary: The decline of the immune system in aging leads to decreased susceptibility to infections and reduced response to vaccination, especially in reacting to new pathogens. Research shows that elderly individuals have a significant reduction in CD27(dull) memory B cells, while having a higher population of specialized antigen-selected CD27(bright) memory B cells. Additionally, B cells from older individuals produce significantly fewer IgM and IgA antibodies compared to younger individuals after in vitro stimulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Infectious Diseases
Mitnala Sasikala, Jaggaiahgari Shashidhar, Gujjarlapudi Deepika, Vishnubhotla Ravikanth, Vemula Venkata Krishna, Yelamanchili Sadhana, Kottapalli Pragathi, Duvvur Nageshwar Reddy
Summary: After a single dose of mRNA vaccine, individuals previously infected with SARS-CoV-2 exhibited higher levels of immune memory compared to those with no prior exposure, including neutralizing antibody response and memory T and B cell counts.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Michael Gurevich, Rina Zilkha-Falb, Polina Sonis, David Magalashvili, Shay Menascu, Shlomo Flechter, Mark Dolev, Mathilda Mandel, Anat Achiron
Summary: This study demonstrates the durability of adaptive cellular immunity for at least 7 months after SARS-CoV-2 infection, suggesting long-lasting protection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Mahsa Eshkevar Vakili, Zahra Faghih, Jamal Sarvari, Mehrnoosh Doroudchi, Seyed Nezamedin Hosseini, Dieter Kabelitz, Kurosh Kalantar
Summary: Despite the availability of an effective vaccine and antiviral treatments, hepatitis B remains a global public health problem. This study compared the frequency of CD4(+) memory T cell subsets between responders and nonresponders to HB vaccination, and identified a lower frequency of CD4(+) T-SCM cells in nonresponders.
IMMUNOLOGIC RESEARCH
(2022)
Article
Immunology
Lin Yao, Guo-Lin Wang, Yuan Shen, Zhuang-Ye Wang, Bing-Dong Zhan, Li-Jun Duan, Bing Lu, Chao Shi, Yu-Meng Gao, Hong-Hong Peng, Guo-Qiang Wang, Dong-Mei Wang, Ming-Dong Jiang, Guo-Ping Cao, Mai-Juan Ma
Summary: This study investigated the humoral and T and B cell responses in COVID-19 patients up to 343 days after infection. It found that most patients still had virus-specific immune memory responses approximately 1 year post-infection, which is promising for prevention from reinfection and vaccination strategies.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Mark A. Daniels, Dezzarae Luera, Emma Teixeiro
Summary: Memory T cells are crucial in protecting against infectious diseases and cancer, but their generation and maintenance are not fully understood. This review focuses on the role of the NF kappa B signaling system in generating and maintaining CD8 T cell memory, and highlights the remaining questions in this field.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Zsofia Bugya, Jozsef Prechl, Tibor Szenasi, Eva Nemes, Attila Bacsi, Gabor Koncz
Summary: Immunological memory is complex and involves different levels of protection against pathogens. The interactions between different B and T cell subsets play a crucial role in the efficacy of vaccines.
Review
Allergy
Gemma E. Hartley, Emily S. J. Edwards, Robyn E. O'Hehir, Menno C. van Zelm
Summary: Since early 2020, the world has been facing a viral pandemic caused by SARS-CoV-2 and its variants, leading to a global mass morbidity and an estimated 6 million deaths. Immunology plays a critical role in combating this pandemic and is essential for successful vaccination and disease treatment. Recent research shows that the formation and durability of immune memory cells following vaccination are associated with protection against severe disease from SARS-CoV-2 infection.
Article
Immunology
Chao-Yi Wu, Hui-Ping Chien, Huang-Yu Yang, Tsung-Chieh Yao, Min-Hua Tseng, Mei-Chin Yu, Kuo-Wei Yeh, Jing-Long Huang
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Immunology
Ting-Chun Lin, Cheng-Chin Kuo, Chao-Yi Wu, Kuo-Wei Yeh, Ming-Ling Kuo, Jing-Long Huang
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Immunology
Chih-Yung Chiu, Chia-Hsuan Yang, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Kuo-Wei Yeh, Jing-Long Huang
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Immunology
Shiuan-Chen Lin, Wen- Lee, Tang-Her Jaing, Chao-Ping Yang, Iou-Jih Hung, Tsung-Yen Chang, Jing-Long Huang, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Shih-Hsiang Chen
Article
Pediatrics
Jhao-Jhuang Ding, Shih-Hua Lin, Jing-Long Huang, Tai-Wei Wu, Shao-Hsuan Hsia, Jainn-Jim Lin, Yu-Ching Chou, Min-Hua Tseng
PEDIATRIC NEPHROLOGY
(2020)
Article
Environmental Sciences
Ching-Yen Kuo, Chin-Kan Chan, Jing-Long Huang, Chiung-Yi Wu, Dinh-Van Phan, Huei-Yu Lo, Chien-Lung Chan
Summary: This study investigated the trends in childhood asthma hospitalization in regions with differing levels of air pollution in Taiwan. The national trend showed a significant decrease in childhood asthma hospitalization. The effects of air pollution on childhood asthma were greater in areas with higher levels of air pollution.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2022)
Article
Allergy
Kuan-Wen Su, Sarita U. Patil, Jennifer L. Stockbridge, Victoria M. Martin, Yamini V. Virkud, Jing-Long Huang, Wayne G. Shreffler, Qian Yuan
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Immunology
Cheryn Yu Wei Choo, Kuo-Wei Yeh, Jing-Long Huang, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, Sui-Ling Liao, Shen-Hao Lai, Li-Chen Chen, Chih-Yung Chiu
Summary: Oxidative stress is correlated with allergic indices and may play a role in modulating allergic responses contributing to the development of atopic diseases.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Pediatrics
Shang Jun Zhang-Jian, Huang-Yu Yang, Meng-Jun Chiu, I-Jun Chou, Chang-Fu Kuo, Jing-Long Huang, Kuo-Wei Yeh, Chao-Yi Wu
PEDIATRIC RHEUMATOLOGY
(2020)
Correction
Pediatrics
Wan-Fang Lee, Chao-Yi Wu, Huang-Yu Yang, Wen- Lee, Li-Chen Chen, Liang-Shiou Ou, Jing-Long Huang
PEDIATRIC RHEUMATOLOGY
(2020)
Article
Multidisciplinary Sciences
Shen-Hao Lai, Ming-Chou Chiang, Shih-Ming Chu, Jen-Fu Hsu, Tsung-Chieh Yao, Ming-Han Tsai, Man-Chin Hua, Chih-Yung Chiu, Kuo-Wei Yeh, Jing-Long Huang, Sui-Ling Liao
SCIENTIFIC REPORTS
(2020)
Article
Biochemistry & Molecular Biology
Meng-Ying Hsieh, Jainn-Jim Lin, Shao-Hsuan Hsia, Jing-Long Huang, Kuo-Wei Yeh, Kuei-Wen Chang, Wen-I. Lee
BIOMEDICAL JOURNAL
(2020)
Article
Immunology
Wen- Lee, Jing-Long Huang, Syh-Jae Lin, Kuo-Wei Yeh, Li-Chen Chen, Liang-Shiou Ou, Tsung-Chieh Yao, Tang-Her Jaing, Ying-Fan Shih, Chao-Yi Wu
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Allergy
Hsin-Ju Lee, Hui-Ju Tsai, Hsin-Yi Huang, Chun-Chun Gau, Chia-Hua Ho, Jing-Long Huang, Tsung-Chieh Yao
Summary: This study found a positive correlation between cord blood IgE levels and allergic sensitization, FeNO elevation, and asthma in Asian schoolchildren. Cord blood IgE could be a useful indicator for identifying newborns at risk for subsequent allergic sensitization and allergic airway inflammation.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2022)