Article
Genetics & Heredity
Yanan Jiang, Huimeng Sun, Hong Xu, Xin Hu, Wenqi Wu, Yangyang Lv, Jinhuan Wang, Su Liu, Yixin Zhai, Linyan Tian, Yafei Wang, Zhigang Zhao
Summary: A study on DLBCL revealed two immune infiltration subtypes and developed a 16-gene risk signature for prognostic prediction. The high-risk group showed lower immune infiltration, more aggressive phenotypes, lower overall survival, and greater sensitivity to lenalidomide, while the low-risk group showed higher immune infiltration, less aggressive phenotypes, better overall survival, and a higher likelihood of benefiting from PD-1/PD-L1 inhibitors.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Xiaolei Wei, Jingxia Zheng, Zewen Zhang, Qiongzhi Liu, Minglang Zhan, Weimin Huang, Junjie Chen, Qi Wei, Yongqiang Wei, Ru Feng
Summary: Consecutive hypoalbuminemia is a simple and effective adverse prognostic factor in patients with diffuse large B-cell lymphoma (DLBCL), independent of International Prognostic Index (IPI), highlighting the importance of monitoring patients with low serum albumin at the end-of-treatment (EoT) for better outcomes during follow-up.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qianhui Gu, Jing Li, Zhuolin Chen, Jie Zhang, Hui Shen, Xiaobing Miao, Ying Zhou, Xiaohong Xu, Song He
Summary: Recent studies have shown that PD-L2 expression is associated with clinicopathological features in DLBCL patients. Higher expression of PD-L2 is correlated with better prognosis and survival outcomes, indicating its potential as a therapeutic target in DLBCL.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yu-Qing Chen, Zi-Fan Yue, Sai-Nan Chen, Fei Tong, Wei-Hua Yang, Rui-Li Wei
Summary: This study is the largest population-based case series of orbital diffuse large B-cell lymphoma (DLBCL) to date, and it found that age at diagnosis, marital status, absence of chemotherapy or radiotherapy, and tumor stage were all correlated with worse prognosis.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Yu-Fen Tsai, Yi-Chang Liu, Ching- Yang, Tzer-Ming Chuang, Ya-Lun Ke, Tsung-Jang Yeh, Yuh-Ching Gau, Jeng-Shiun Du, Hui-Ching Wang, Shih-Feng Cho, Chin-Mu Hsu, Pey-Fang Wu, Ching- Huang, Chung-Feng Huang, Ming-Lung Yu, Chia-Yen Dai, Hui-Hua Hsiao
Summary: HCV-positive DLBCL patients show poorer performance status, higher complication rates, and intolerance to treatment, leading to fewer treatment cycles and inferior survival outcomes.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Chunli Yang, Qiaoer Li, Ke Xie, Yakun Zhang, Dania Xiang, Yunwei Han, Liqun Zou
Summary: This study provides insights into the clinical characteristics, treatment strategies, and survival outcomes of elderly patients with DLBCL in China. It highlights the importance of careful evaluation of toxicities and treatment doses in optimizing the management of these patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Xianting Sun, Jianchen Fang, Fen Ye, Shuxian Zhang, Honghui Huang, Jian Hou, Ting Wang
Summary: This study identified the existence of endothelial-to-mesenchymal transition (EndMT) in diffuse large B-cell lymphoma (DLBCL) associated endothelial cells and its clinical relevance. DLBCL cells were found to stimulate angiogenesis and EndMT of human umbilical vein endothelial cells (HUVECs). The molecular mechanisms underlying this process were also unveiled, with WNT10A/GSK3β/β-catenin/snail pathway playing vital roles in DLBCL-induced EndMT. These findings suggest that EndMT markers and WNT10A may serve as novel predictors of clinical outcome in DLBCL.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Lingna Zhou, Liya Ding, Yuqi Gong, Jing Zhao, Jing Zhang, Zhengrong Mao, Zhe Wang, Wei Zhang, Ren Zhou
Summary: The study found that NEK2 is upregulated in DLBCL and predicts a poor prognosis for patients. NEK2 may participate in the occurrence and development of DLBCL by regulating glycolysis, and its interaction with PKM2 affects the growth and metabolism of DLBCL cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Kristina Sonnevi, Tove Wasterlid, Christopher M. Melen, Sara Harrysson, Karin E. Smedby, Bjorn E. Wahlin
Summary: Elderly patients aged over 80 with diffuse large B-cell lymphoma may benefit from rituximab-anthracycline-based treatment given with curative intent. Survival differences between regions are likely due to therapeutic variances and intensity of treatment.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Oncology
Hong Zeng, Yongqiang Wei, Xiaolei Wei, Ru Feng
Summary: The study found that in diffuse large B-cell lymphoma, LINC00908 promotes malignancy by regulating miR-671-5p. Silencing LINC00908 significantly inhibits the growth of DLBCL.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Nutrition & Dietetics
Giulia Besutti, Fulvio Massaro, Efrem Bonelli, Luca Braglia, Massimiliano Casali, Annibale Versari, Guido Ligabue, Pierpaolo Pattacini, Silvio Cavuto, Domenico F. Merlo, Stefano Luminari, Francesco Merli, Salvatore Vaccaro, Massimo Pellegrini
Summary: The study on muscle quality and fat compartment distributions in DLBCL patients revealed that reduced skeletal muscle density (SMD) and increased intermuscular adipose tissue (IMAT) at the L3 and proximal thigh levels are associated with poor prognosis, rather than low muscle quantity (SMI).
FRONTIERS IN NUTRITION
(2021)
Review
Oncology
Maria Huguet, Jose-Tomas Navarro, Jose Molto, Josep-Maria Ribera, Gustavo Tapia
Summary: Non-Hodgkin lymphoma (NHL) is a common HIV-related neoplasm, with diffuse large B-cell lymphoma (DLBCL) being the most common subtype. DLBCL in people with HIV presents with aggressive characteristics. The introduction of combined antiretroviral therapy (cART) and the use of cART with chemotherapy have significantly improved the prognosis for people with HIV and DLBCL, approaching that of the general population.
Article
Nutrition & Dietetics
Peizhan Chen, Yiwen Cao, Xiaohua Duan, Jingquan Li, Weili Zhao, Hui Wang
Summary: This study found that DLBCL patients with higher plasma bioavailable 25(OH)D levels have better progression-free survival and overall survival, as well as being more sensitive to R-CHOP regimen treatments.
CLINICAL NUTRITION
(2021)
Article
Oncology
Karishma Khullar, Jesse J. Plascak, Richard Drachtman, Peter D. Cole, Rahul R. Parikh
Summary: The study found that racial disparities in survival may be mediated by clinical and treatment parameters. Patients with B symptoms, those with Other insurance, and those who did not receive chemotherapy had a higher risk of death, while patients with earlier stage disease were less likely to die from their disease.
Article
Oncology
Bingxin Zhang, Tianyu Zhang, Ziwei Zheng, Zhili Lin, Quanqiang Wang, Dong Zheng, Zixing Chen, Yongyong Ma
Summary: By systematically evaluating the molecular changes of CRGs in DLBCL, we identified two distinct subtypes associated with prognosis. We built a prognostic model based on CRG expression profiles and validated its accuracy through various methods. Moreover, a nomogram combining clinical features and risk score showed superior predictive accuracy compared to the International Prognostic Index.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Warren Fiskus, Christopher P. Mill, Dimuthu Perera, Christine Birdwell, Qing Deng, Haopeng Yang, Bernardo H. Lara, Nitin Jain, Jan Burger, Alessandra Ferrajoli, John A. Davis, Dyana T. Saenz, Wendy Jin, Cristian Coarfa, Craig M. Crews, Michael R. Green, Joseph D. Khoury, Kapil N. Bhalla
Summary: This study reports the characteristics of three newly established patient-derived xenograft models of RT-DLBCL, including genetic alterations, gene expressions, and drug sensitivity. The findings suggest potential novel therapies for RT-DLBCL, including BET protein inhibitors.
Article
Hematology
Man Chun John Ma, Saber Tadros, Alyssa Bouska, Tayla Heavican, Haopeng Yang, Qing Deng, Dalia Moore, Ariz Akhter, Keenan Hartert, Neeraj Jain, Jordan Showell, Sreejoyee Ghosh, Lesley Street, Marta Davidson, Christopher Carey, Joshua Tobin, Deepak Perumal, Julie M. Vose, Matthew A. Lunning, Aliyah R. Sohani, Benjamin J. Chen, Shannon Buckley, Loretta J. Nastoupil, R. Eric Davis, Jason R. Westin, Nathan H. Fowler, Samir Parekh, Maher Gandhi, Sattva Neelapu, Douglas Stewart, Kapil Bhalla, Javeed Iqbal, Timothy Greiner, Scott J. Rodig, Adnan Mansoor, Michael R. Green
Summary: This study comprehensively analyzed the genomic landscapes of multiple B-cell non-Hodgkin lymphoma (B-NHL) subtypes, and identified common features and subtype-specific patterns of genetic alterations. The study also revealed potential patterns of genetic cooperation that contribute to lymphomagenesis, providing important insights into the pathogenesis of B-NHL.
Article
Hematology
Hua-Jay J. Cherng, Ryan Sun, Bryant Sugg, Russell Irwin, Haopeng Yang, Cao Cuong Le, Qing Deng, Luis Fayad, Nathan H. Fowler, Simrit Parmar, Raphael Steiner, Fredrick Hagemeister, Ranjit Nair, Hun Ju Lee, Maria Rodriguez, Felipe Samaniego, Swaminathan P. Iyer, Christopher R. Flowers, Linghua Wang, Loretta J. Nastoupil, Sattva S. Neelapu, Sairah Ahmed, Paolo Strati, Michael R. Green, Jason Westin
Summary: IpWGS of cfDNA can be used for risk stratification to identify high-risk patients and guide patient selection and evaluation of targeted therapies in future clinical trials.
Article
Biochemistry & Molecular Biology
Zhuoyao Chen, Rafael M. Ioris, Stacey Richardson, Ava N. Van Ess, Iolanda Vendrell, Benedikt M. Kessler, Francesca M. Buffa, Luca Busino, Steven C. Clifford, Alex N. Bullock, Vincenzo D'Angiolella
Summary: Medulloblastoma is a common malignant brain tumor in children, and it has been found to have different subtypes based on genomic studies. WNT and SHH signaling pathway alterations are known to be the main causes for their subtypes, but the causes for non-WNT/non-SHH tumors are still largely unknown. Recent studies have identified KBTBD4 gene mutations as important drivers in group 3 and group 4 medulloblastomas. These mutations promote significant changes in chromatin accessibility and transcriptional programs, leading to increased stemness of cancer cells.
CELL DEATH AND DIFFERENTIATION
(2022)
Article
Oncology
Jason Westin, R. Eric Davis, Lei Feng, Fredrick Hagemeister, Raphael Steiner, Hun Ju Lee, Luis Fayad, Loretta Nastoupil, Sairah Ahmed, Alma Rodriguez, Michelle Fanale, Felipe Samaniego, Swaminathan P. Iyer, Ranjit Nair, Yasuhiro Oki, Nathan Fowler, Michael Wang, Man Chun John Ma, Francisco Vega, Timothy McDonnell, Chelsea Pinnix, Donna Griffith, Yang Lu, Sanjit Tewari, Ryan Sun, David W. Scott, Christopher R. Flowers, Sattva Neelapu, Michael R. Green
Summary: This study introduces a new treatment strategy (RLI) for newly diagnosed DLBCL patients, which combines targeted therapy with drugs before chemotherapy. The results showed high treatment response rates and durable responses in DLBCL patients treated with RLI. This establishes the potential for developing biologically driven and noncytotoxic first-line therapies for DLBCL.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Genetics & Heredity
Alessandro Scacchetti, Roberto Bonasio
Summary: A new study used CRISPR-Cas9-based base editing to simultaneously mutate all copies of histone H3 genes in mammals, revealing the functional importance of H3K27me3 in Polycomb-mediated gene silencing and the dispensability of H3K27ac in transcriptional activation.
Article
Biochemistry & Molecular Biology
Naihua N. Gong, Hang Ngoc Bao Luong, An H. Dang, Benjamin Mainwaring, Emily Shields, Karl Schmeckpeper, Roberto Bonasio, Matthew S. Kayser
Summary: The study reveals that the transcriptional states of sleep output neurons play a crucial role in the changes in sleep across the lifespan in fruit flies.
Editorial Material
Oncology
Joshua W. D. Tobin, Michael R. Green, Maher K. Gandhi
CANCER IMMUNOLOGY RESEARCH
(2022)
Review
Oncology
Jingwen Yang, Yamei Chen, Ying Jing, Michael R. Green, Leng Han
Summary: This article provides an overview of the multidimensional profiling technologies used in CAR T cell therapy research and discusses the utilization of multi-omics data to elucidate CAR targets, factors associated with response or resistance to therapy, and underlying toxicities. These findings can potentially enhance the efficacy and safety of CAR T cell therapies.
NATURE REVIEWS CLINICAL ONCOLOGY
(2023)
Article
Cell Biology
Lihong Sheng, Emily J. J. Shields, Janko Gospocic, Masato Sorida, Linyang Ju, China N. N. Byrns, Faith Carranza, Shelley L. L. Berger, Nancy Bonini, Roberto Bonasio
Summary: By studying the changes in the number and gene expression of ensheathing glia in Drosophila melanogaster brain, it is found that dysregulated ensheathing glia can lead to lipid droplet accumulation, cellular dysfunction, and death, affecting brain health and lifespan. Inhibition of apoptosis can restore the declining number of ensheathing glia with age, improve the neuro-motor performance of aged fruit flies and prolong lifespan. Furthermore, an expanded ensheathing glia population can prevent amyloid-beta accumulation in a fly model of Alzheimer's disease and delay the premature death of diseased animals. These findings highlight the vital role of ensheathing glia in regulating brain health and animal longevity.
Article
Cell Biology
Karl M. Glastad, Julian Roessler, Janko Gospocic, Roberto Bonasio, Shelley L. Berger
Summary: In this study, the researchers investigate the role of heat shock responses mediated by hsalHSF2 in extending the longevity and survival of reproductive gamergate ants. They show that the increased heat stress resilience and life span benefits observed in gamergates can be transferred to fruit flies through the expression of hsalHSF2. The study sheds light on the mechanisms underlying the extended life span of gamergates, highlighting the significance of hsalHSF2 in ant longevity. It also underscores the importance of proteostasis in health and aging, as well as the potential for facultative life span extension in ants.
GENES & DEVELOPMENT
(2023)
Article
Oncology
Sebastian Scheich, Jiji Chen, Jiamin Liu, Frank Schnutgen, Julius C. Enssle, Michele Ceribelli, Craig J. Thomas, Jaewoo Choi, Vivian Morris, Tony Hsiao, Hang Nguyen, Boya Wang, Arnold Bolomsky, James D. Phelan, Sean Corcoran, Henning Urlaub, Ryan M. Young, Bjorn Haupl, George W. Wright, Da Wei Huang, Yanlong Ji, Xin Yu, Weihong Xu, Yandan Yang, Hong Zhao, Jagan Muppidi, Kuan-Ting Pan, Thomas Oellerich, Louis M. Staudt
Summary: Diffuse large B-cell lymphoma (DLBCL) can be categorized into two subtypes: activated B-cell (ABC) and germinal center B cell-like (GCB). The study found that self-antigen engagement of B-cell receptors (BCR) in ABC tumors triggers clustering, activating chronic active signaling and NF-KB and PI3 kinase. Genome-wide CRISPR-Cas9 screens were used to identify regulators of IRF4, a direct transcriptional target of NF-KB and an indicator of proximal BCR signaling in ABC DLBCL. Inactivation of N-linked protein glycosylation by the OST-B complex reduced IRF4 expression and targeting OST-B inhibition killed models of ABC and GCB DLBCL, suggesting the potential for selective OST-B inhibitors in treating these aggressive cancers.
Article
Oncology
Guangchun Han, Qing Deng, Mario L. Marques-Piubelli, Enyu Dai, Minghao Dang, Man Chun John Ma, Xubin Li, Haopeng Yang, Jared Henderson, Olga Kudryashova, Mark Meerson, Sergey Isaev, Nikita Kotlov, Krystle J. Nomie, Alexander Bagaev, Edwin R. Parra, Luisa M. Solis Soto, Simrit Parmar, Fredrick B. Hagemeister, Sairah Ahmed, Swaminathan P. Iyer, Felipe Samaniego, Raphael Steiner, Luis Fayad, Hun Lee, Nathan H. Flower, Christopher R. Flowers, Paolo Strati, Jason R. Westin, Sattva S. Neelapu, Loretta J. Nastoupil, Francisco Vega, Linghua Wang, Michael R. Green
Summary: In this study, the tumor and immune cell populations of follicular lymphoma (FL) were characterized using single-cell RNA sequencing. Different subsets of T cells were identified, including cytotoxic CD4 T cells. Somatic mutations were found to be associated with reduced MHC expression on FL cells. The expression of MHCII genes by FL cells was correlated with significant differences in the proportions and immunophenotypic characteristics of T cells.
BLOOD CANCER DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Colin S. McCoin, Edziu Franczak, Michael P. Washburn, Mihaela E. Sardiu, John P. Thyfault
Summary: The study utilized proteomics to analyze the effects of exercise on the mitochondrial proteome in female mice, revealing rapid changes in mitochondrial protein/pathways with acute exercise, including fatty acid metabolism/storage, post-translational protein modification, inflammation, and oxidative stress.
Meeting Abstract
Oncology
Zhuoyao Chen, Rafael Ioris, Stacey Richardson, Ava Van Ess, Iolanda Vendrell, Benedikt Kessler, Francesca Buffa, Luca Busino, Steven Clifford, Alex Bullock, Vincenzo D'Angiolella
