The Catalysis Laboratory at Merck: 20 Years of Catalyzing Innovation

Electrochemically driven cross-electrophile coupling of alkyl halides

(2022) Wen Zhang et al.   NATURE

Air-Tolerant Nickel-Catalyzed Cyanation of (Hetero)aryl Halides Enabled by Polymethylhydrosiloxane, a Green Reductant

(2022) J. Caleb Hethcox et al.   JOURNAL OF ORGANIC CHEMISTRY

Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454

(2022) Tamas Benkovics et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Efficient Aliphatic Hydrogen-Isotope Exchange with Tritium Gas through the Merger of Photoredox and Hydrogenation Catalysts

(2022) Haifeng Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Scaffold hopping by net photochemical carbon deletion of azaarenes

(2022) Jisoo Woo et al.   SCIENCE

Cationic Bis(phosphine) Cobalt(I) Arene Complexes as Precatalysts for the Asymmetric Synthesis of Sitagliptin

(2022) Connor S. MacNeil et al.   ACS Catalysis

Variable Temperature LED–NMR: Rapid Insights into a Photocatalytic Mechanism from Reaction Progress Kinetic Analysis

(2022) Wesley B. Swords et al.   JOURNAL OF ORGANIC CHEMISTRY

Mechanistic Investigations of the Asymmetric Hydrogenation of Enamides with Neutral Bis(phosphine) Cobalt Precatalysts

(2022) Lauren N. Mendelsohn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling up Electrosynthesis

(2022) Cecilia Bottecchia et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Chemistry Informer Libraries: Conception, Early Experience, and Role in the Future of Cheminformatics

(2021) Spencer D. Dreher et al.   ACCOUNTS OF CHEMICAL RESEARCH

Late-Stage Carbon Isotope Exchange of Aryl Nitriles through Ni-Catalyzed C–CN Bond Activation

(2021) Sean W. Reilly et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harnessing the Power of Catalysis for the Synthesis of CRTH2 Antagonist MK-1029

(2021) Rebecca T. Ruck et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Electrochemical Activation of Galactose Oxidase: Mechanistic Studies and Synthetic Applications

(2021) Shaoguang Zhang et al.   ACS Catalysis

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

(2021) Jonas Rein et al.   ACS Central Science

Photocatalysis in the Life Science Industry

(2021) Lisa Candish et al.   CHEMICAL REVIEWS

Benzylic Photobromination for the Synthesis of Belzutifan: Elucidation of Reaction Mechanisms Using In Situ LED-NMR

(2021) Yining Ji et al.   JOURNAL OF ORGANIC CHEMISTRY

Manufacturing Process Development for Belzutifan, Part 2: A Continuous Flow Visible-Light-Induced Benzylic Bromination

(2021) Cecilia Bottecchia et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts

(2021) Katrina W. Lexa et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

(2021) John A. McIntosh et al.   ACS Central Science

Late‐Stage 18 O Labeling of Primary Sulfonamides via a Degradation–Reconstruction Pathway

(2020) Sean W. Reilly et al.   CHEMISTRY-A EUROPEAN JOURNAL

Base metal-catalyzed hydrogen isotope exchange

(2020) Haifeng Yang et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Cobalt-Catalyzed Asymmetric Hydrogenation of α,β-Unsaturated Carboxylic Acids by Homolytic H2 Cleavage

(2020) Hongyu Zhong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Photons as a 21st century reagent

(2020) Holly E. Bonfield et al.   Nature Communications

Photon Equivalents as a Parameter for Scaling Photoredox Reactions in Flow: Translation of Photocatalytic C−N Cross‐Coupling from Lab Scale to Multikilogram Scale

(2020) Emily B. Corcoran et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The merger of decatungstate and copper catalysis to enable aliphatic C(sp3)–H trifluoromethylation

(2020) Patrick J. Sarver et al.   Nature Chemistry

Harder, better, faster

(2020) Danielle Schultz et al.   Nature Chemistry

Ruthenium-Catalyzed Enantioselective Hydrogenation of Hydrazones

(2020) Christopher H. Schuster et al.   ORGANIC LETTERS

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview

(2020) Hong Ren et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Visible-Light Photocatalysis as an Enabling Technology for Drug Discovery: A Paradigm Shift for Chemical Reactivity

(2020) Peijun Li et al.   ACS Medicinal Chemistry Letters

Metallaphotoredox aryl and alkyl radiomethylation for PET ligand discovery

(2020) Robert W. Pipal et al.   NATURE

Design of a Kilogram Scale, Plug Flow Photoreactor Enabled by High Power LEDs

(2020) François Lévesque et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of Isotopically Labeled Anti-HIV Nucleoside Islatravir through a One-Pot Biocatalytic Cascade Reaction

(2020) Sumei Ren et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Ni(I)–X Complexes Bearing a Bulky α-Diimine Ligand: Synthesis, Structure, and Superior Catalytic Performance in the Hydrogen Isotope Exchange in Pharmaceuticals

(2019) Cayetana Zarate et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Evolution of High-Throughput Experimentation in Pharmaceutical Development, and Perspectives on the Future

(2019) Steven M Mennen et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highlights of C (sp2 )-H hydrogen isotope Exchange Reactions

(2019) David Hesk   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Preparation of 2-(2H-Tetrazol-2-yl)benzoic Acids via Regioselective Cu(I) Catalyzed N2 Arylation of Tetrazole

(2019) Zhiguo Jake Song et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Using an Automated Monitoring Platform for Investigations of Biphasic Reactions

(2019) Jordan A. Daponte et al.   ACS Catalysis

Electrochemical Synthesis of Hindered Primary and Secondary Amines via Proton-Coupled Electron Transfer

(2019) Dan Lehnherr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of an in vitro biocatalytic cascade for the manufacture of islatravir

(2019) Mark A. Huffman et al.   SCIENCE

Selective Hydrogen Atom Abstraction through Induced Bond Polarization: Direct α-Arylation of Alcohols through Photoredox, HAT, and Nickel Catalysis

(2018) Jack Twilton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium(II)-Mediated C−H Tritiation of Complex Pharmaceuticals

(2018) Haifeng Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C−H Functionalisation for Hydrogen Isotope Exchange

(2018) Jens Atzrodt et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile Quantum Yield Determination via NMR Actinometry

(2018) Yining Ji et al.   ORGANIC LETTERS

Improved Preparation of a Key Hydroxylamine Intermediate for Relebactam: Rate Enhancement of Benzyl Ether Hydrogenolysis with DABCO

(2018) Jianguo Yin et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction

(2018) Max R. Friedfeld et al.   SCIENCE

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS

(2018) Shishi Lin et al.   SCIENCE

Discovery of a Photoinduced Dark Catalytic Cycle using in situ LED-NMR Spectroscopy

(2018) Dan Lehnherr et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct arylation of strong aliphatic C–H bonds

(2018) Ian B. Perry et al.   NATURE

Site-Selective Nickel-Catalyzed Hydrogen Isotope Exchange in N-Heterocycles and Its Application to the Tritiation of Pharmaceuticals

(2018) Haifeng Yang et al.   ACS Catalysis

Palladium-Catalyzed Carbon Isotope Exchange on Aliphatic and Benzoic Acid Chlorides

(2018) Donald R. Gauthier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Potassium isopropyl xanthate (PIX): an ultra-efficient palladium scavenger

(2017) Hong Ren et al.   GREEN CHEMISTRY

Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin

(2017) Feng Peng et al.   JOURNAL OF ORGANIC CHEMISTRY

Asymmetric Hydrogen Bonding Catalysis for the Synthesis of Dihydroquinazoline-Containing Antiviral, Letermovir

(2017) Cheol K. Chung et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Practical Asymmetric Synthesis of a Calcitonin Gene-Related Peptide (CGRP) Receptor Antagonist Ubrogepant

(2017) Nobuyoshi Yasuda et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

A multifunctional catalyst that stereoselectively assembles prodrugs

(2017) Daniel A. DiRocco et al.   SCIENCE

Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds

(2017) Yong Yao Loh et al.   SCIENCE

A rational pre-catalyst design for bis-phosphine mono-oxide palladium catalyzed reactions

(2017) Yining Ji et al.   Chemical Science

Practical High-Throughput Experimentation for Chemists

(2017) Michael Shevlin   ACS Medicinal Chemistry Letters

A General Small-Scale Reactor To Enable Standardization and Acceleration of Photocatalytic Reactions

(2017) Chi “Chip” Le et al.   ACS Central Science

Selective functionalization of complex heterocycles via an automated strong base screening platform

(2017) Sobhana Babu Boga et al.   Reaction Chemistry & Engineering

Hepatitis C virus NS3/4a protease inhibitors

(2016) John A McCauley et al.   CURRENT OPINION IN PHARMACOLOGY

Enantioselective Synthesis of α-Methyl-β-cyclopropyldihydrocinnamates

(2016) Melodie Christensen et al.   JOURNAL OF ORGANIC CHEMISTRY

Acridinium-Based Photocatalysts: A Sustainable Option in Photoredox Catalysis

(2016) Amruta Joshi-Pangu et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

Cobalt-Catalyzed Enantioselective Hydrogenation of Minimally Functionalized Alkenes: Isotopic Labeling Provides Insight into the Origin of Stereoselectivity and Alkene Insertion Preferences

(2016) Max R. Friedfeld et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nickel-Catalyzed Asymmetric Alkene Hydrogenation of α,β-Unsaturated Esters: High-Throughput Experimentation-Enabled Reaction Discovery, Optimization, and Mechanistic Elucidation

(2016) Michael Shevlin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction

(2016) Alan M. Hyde et al.   ORGANIC LETTERS

A Robust Kilo-Scale Synthesis of Doravirine

(2016) Louis-Charles Campeau et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Asymmetric Synthesis of Letermovir Using a Novel Phase-Transfer-Catalyzed Aza-Michael Reaction

(2016) Guy R. Humphrey et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Visible Light Photocatalysis: Applications and New Disconnections in the Synthesis of Pharmaceutical Agents

(2016) James J. Douglas et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Aryl amination using ligand-free Ni(II) salts and photoredox catalysis

(2016) Emily B. Corcoran et al.   SCIENCE

An approach to heterodiarylmethanes via sp 2 –sp 3 Suzuki−Miyaura cross-coupling

(2016) Gavin W. Stewart et al.   TETRAHEDRON

Discovery and mechanistic study of a photocatalytic indoline dehydrogenation for the synthesis of elbasvir

(2016) Hatice G. Yayla et al.   Chemical Science

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods

(2016) Peter S. Kutchukian et al.   Chemical Science

Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides

(2015) Hongming Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd-Catalyzed C–N, C–O, and C–C Cross-Coupling Reactions

(2015) Alexander Buitrago Santanilla et al.   ORGANIC LETTERS

Development of a Direct Photocatalytic C–H Fluorination for the Preparative Synthesis of Odanacatib

(2015) Shira D. Halperin et al.   ORGANIC LETTERS

Contemporary Asymmetric Phase Transfer Catalysis: Large-Scale Industrial Applications

(2015) Jiajing Tan et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Discovery and Application of Doubly Quaternized Cinchona-Alkaloid-Based Phase-Transfer Catalysts

(2014) Bangping Xiang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Late-Stage Functionalization of Biologically Active Heterocycles Through Photoredox Catalysis

(2014) Daniel A. DiRocco et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper catalysed Ullmann type chemistry: from mechanistic aspects to modern development

(2014) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis

(2014) Behnaz Ghaffari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Unusual Pyrimidine Participation: Efficient Stereoselective Synthesis of Potent Dual Orexin Receptor Antagonist MK-6096

(2014) John Y. L. Chung et al.   ORGANIC LETTERS

Enantioselective Synthesis of an HCV NS5a Antagonist

(2014) Ian K. Mangion et al.   ORGANIC LETTERS

Experimental Limiting Oxygen Concentrations for Nine Organic Solvents at Temperatures and Pressures Relevant to Aerobic Oxidations in the Pharmaceutical Industry

(2014) Paul M. Osterberg et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Practical Synthesis of A Macrocyclic HCV Protease Inhibitor: A High-Yielding Macrolactam Formation

(2014) Zhiguo J. Song et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis and Hydrogenation Activity of Iron Dialkyl Complexes with Chiral Bidentate Phosphines

(2014) Jordan M. Hoyt et al.   ORGANOMETALLICS

Nanomole-scale high-throughput chemistry for the synthesis of complex molecules

(2014) A. Buitrago Santanilla et al.   SCIENCE

A Traceless Directing Group for CH Borylation

(2013) Sean M. Preshlock et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

C–N bond forming cross-coupling reactions: an overview

(2013) Jitender Bariwal et al.   CHEMICAL SOCIETY REVIEWS

LED based NMR illumination device for mechanistic studies on photochemical reactions – Versatile and simple, yet surprisingly powerful

(2013) C. Feldmeier et al.   JOURNAL OF MAGNETIC RESONANCE

High-Throughput Optimization of Ir-Catalyzed C–H Borylation: A Tutorial for Practical Applications

(2013) Sean M. Preshlock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of a Practical, Asymmetric Synthesis of the Hepatitis C Virus Protease Inhibitor MK-5172

(2013) Jeffrey Kuethe et al.   ORGANIC LETTERS

Process Development of C–N Cross-Coupling and Enantioselective Biocatalytic Reactions for the Asymmetric Synthesis of Niraparib

(2013) Cheol K. Chung et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

CO Cross-Coupling of Activated Aryl and Heteroaryl Halides with Aliphatic Alcohols

(2012) Peter E. Maligres et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of the HCV Protease Inhibitor Vaniprevir (MK-7009) Using Ring-Closing Metathesis Strategy

(2012) Jongrock Kong et al.   JOURNAL OF ORGANIC CHEMISTRY

A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings

(2012) Peter E. Maligres et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Synthesis of a Dual Orexin Receptor Antagonist

(2012) Ian K. Mangion et al.   ORGANIC LETTERS

Convergent, Kilogram Scale Synthesis of an Akt Kinase Inhibitor

(2012) Pintipa Grongsaard et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Synthesis of Vaniprevir (MK-7009): Lactamization To Prepare a 22-Membered Macrocycle

(2011) Zhiguo J. Song et al.   JOURNAL OF ORGANIC CHEMISTRY

A Practical Synthesis of Renin Inhibitor MK-1597 (ACT-178882) via Catalytic Enantioselective Hydrogenation and Epimerization of Piperidine Intermediate

(2011) Carmela Molinaro et al.   JOURNAL OF ORGANIC CHEMISTRY

Reaction Development and Mechanistic Study of a Ruthenium Catalyzed Intramolecular Asymmetric Reductive Amination en Route to the Dual Orexin Inhibitor Suvorexant (MK-4305)

(2011) Neil A. Strotman et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Concise Synthesis of a β-Lactamase Inhibitor

(2011) Ian K. Mangion et al.   ORGANIC LETTERS

The First Large-Scale Synthesis of MK-4305: A Dual Orexin Receptor Antagonist for the Treatment of Sleep Disorder

(2011) Carl A. Baxter et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Transition Metal-Catalyzed Enantioselective Hydrogenation of Enamines and Imines

(2010) Jian-Hua Xie et al.   CHEMICAL REVIEWS

Metal-catalysed hydrogen isotope exchange labelling: a brief overview

(2010) William J. S. Lockley et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Metal-catalysed isotopic exchange labelling: 30 years of experience in pharmaceutical R&D

(2010) Paul H. Allen et al.   JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS

Asymmetric Synthesis of Telcagepant, a CGRP Receptor Antagonist for the Treatment of Migraine

(2010) Feng Xu et al.   JOURNAL OF ORGANIC CHEMISTRY

Stereospecific Cross-Coupling of Secondary Alkyl β-Trifluoroboratoamides

(2010) Deidre L. Sandrock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Regioselective Palladium-Catalyzed Direct Arylation of Oxazole at C-2 or C-5 with Aryl Bromides, Chlorides, and Triflates

(2010) Neil A. Strotman et al.   ORGANIC LETTERS

Asymmetric Hydrogenation of Protected Allylic Amines

(2010) Dietrich P. Steinhuebel et al.   ORGANIC LETTERS

Development of a Kilogram-Scale Asymmetric Synthesis of a Potent DP Receptor Antagonist

(2010) Matthew Tudge et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enantioselective Synthesis of (1R,2S)-1-Amino-2-vinylcyclopropanecarboxylic Acid Ethyl Ester (Vinyl-ACCA-OEt) by Asymmetric Phase-Transfer Catalyzed Cyclopropanation of (E)-N-Phenylmethyleneglycine Ethyl Ester

(2010) Kevin M. Belyk et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Sulfate additives generate robust and highly active palladium catalysts for the cyanation of aryl chlorides

(2010) Michael Shevlin   TETRAHEDRON LETTERS

Dialkylbiaryl phosphines in Pd-catalyzed amination: a user's guide

(2010) David S. Surry et al.   Chemical Science

Suzuki−Miyaura Cross-Coupling Reactions of Primary Alkyltrifluoroborates with Aryl Chlorides

(2009) Spencer D. Dreher et al.   JOURNAL OF ORGANIC CHEMISTRY

Enantioselective Hydrogenation of N−H Imines

(2009) Guohua Hou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Highly Efficient Asymmetric Synthesis of Sitagliptin

(2009) Karl B. Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dynamic Kinetic Asymmetric Allylation of Hydrazines and Hydroxylamines

(2009) Ian Mangion et al.   ORGANIC LETTERS

Iridium-Catalyzed X−H Insertions of Sulfoxonium Ylides

(2009) Ian K. Mangion et al.   ORGANIC LETTERS

Dynamic Kinetic Resolution: Asymmetric Transfer Hydrogenation of α-Alkyl-Substituted β-Ketoamides

(2009) John Limanto et al.   ORGANIC LETTERS

New Efficient Asymmetric Synthesis of Taranabant, a CB1R Inverse Agonist for the Treatment of Obesity

(2009) Debra J. Wallace et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Enantioselective synthesis of a chiral fluoropiperidine via asymmetric hydrogenation of a vinyl fluoride

(2009) Shane W. Krska et al.   TETRAHEDRON

Evolution of a Fourth Generation Catalyst for the Amination and Thioetherification of Aryl Halides

(2008) John F. Hartwig   ACCOUNTS OF CHEMICAL RESEARCH

Palladium-Catalyzed Tandem Heck Reaction/CH Functionalization—Preparation of Spiro-Indane-Oxindoles

(2008) Rebecca T. Ruck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Copper-Mediated Coupling Reactions and Their Applications in Natural Products and Designed Biomolecules Synthesis

(2008) Gwilherm Evano et al.   CHEMICAL REVIEWS

Synthesis of a Tertiary Carbinamide via a Novel Rh-Catalyzed Asymmetric Hydrogenation

(2008) John Limanto et al.   JOURNAL OF ORGANIC CHEMISTRY

Efficient Cross-Coupling of Secondary Alkyltrifluoroborates with Aryl ChloridesReaction Discovery Using Parallel Microscale Experimentation

(2008) Spencer D. Dreher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY