Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 18, Issue 3, Pages 423-430Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op400331j
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A practical synthesis of a macrocyclic HCV protease inhibitor, MK-1220, is described. The key features are a new synthesis of the trisubstituted isoquinoline, Sonogashira fragment coupling, and a high-yielding, 18-membered macrolactam formation.
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