The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Authors
Keywords
-
Journal
Nature Communications
Volume 14, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2023-02-02
DOI
10.1038/s41467-023-36058-2
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- VCP suppresses proteopathic seeding in neurons
- (2022) Jiang Zhu et al. Molecular Neurodegeneration
- In situ architecture of neuronal α-Synuclein inclusions
- (2021) Victoria A. Trinkaus et al. Nature Communications
- Proteomic landscape of Alzheimer’s Disease: novel insights into pathogenesis and biomarker discovery
- (2021) Bing Bai et al. Molecular Neurodegeneration
- Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner
- (2021) Youngdae Gwon et al. SCIENCE
- The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model
- (2021) Patricia Yuste-Checa et al. Nature Communications
- Translocation of polyubiquitinated protein substrates by the hexameric Cdc48 ATPase
- (2021) Zhejian Ji et al. MOLECULAR CELL
- Structure-based classification of tauopathies
- (2021) Yang Shi et al. NATURE
- The Hsc70 disaggregation machinery removes monomer units directly from α-synuclein fibril ends
- (2021) Matthias M. Schneider et al. Nature Communications
- Novel tau filament fold in corticobasal degeneration
- (2020) Wenjuan Zhang et al. NATURE
- Cell‐to‐cell transmission of C9orf72 poly‐(Gly‐Ala) triggers key features of ALS / FTD
- (2020) Bahram Khosravi et al. EMBO JOURNAL
- Disassembly of Tau fibrils by the human Hsp70 disaggregation machinery generates small seeding-competent species
- (2020) Eliana Nachman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases
- (2020) Jordan J. S. VerPlank et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Autosomal dominant VCP hypomorph mutation impairs disaggregation of PHF-tau
- (2020) Nabil F. Darwich et al. SCIENCE
- Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme
- (2019) Rachel Cliffe et al. Cell Reports
- Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
- (2019) Benjamin Falcon et al. NATURE
- MAPT mutations, tauopathy, and mechanisms of neurodegeneration
- (2019) Kevin H. Strang et al. LABORATORY INVESTIGATION
- Propagation of Protein Aggregation in Neurodegenerative Diseases
- (2019) Jaime Vaquer-Alicea et al. Annual Review of Biochemistry
- Substrate processing by the Cdc48 ATPase complex is initiated by ubiquitin unfolding
- (2019) Edward C. Twomey et al. SCIENCE
- Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing
- (2019) Emily E. Blythe et al. STRUCTURE
- In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment
- (2018) Qiang Guo et al. CELL
- Cellular Handling of Protein Aggregates by Disaggregation Machines
- (2018) Axel Mogk et al. MOLECULAR CELL
- VCP/p97-Mediated Unfolding as a Principle in Protein Homeostasis and Signaling
- (2018) Johannes van den Boom et al. MOLECULAR CELL
- A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment
- (2018) Marc L Hyer et al. NATURE MEDICINE
- Protein Disaggregation in Multicellular Organisms
- (2018) Nadinath B. Nillegoda et al. TRENDS IN BIOCHEMICAL SCIENCES
- Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease
- (2018) Michael C. Pace et al. ACTA NEUROPATHOLOGICA
- Structures of filaments from Pick’s disease reveal a novel tau protein fold
- (2018) Benjamin Falcon et al. NATURE
- Propagation and spread of pathogenic protein assemblies in neurodegenerative diseases
- (2018) Mathias Jucker et al. NATURE NEUROSCIENCE
- The PRIDE database and related tools and resources in 2019: improving support for quantification data
- (2018) Yasset Perez-Riverol et al. NUCLEIC ACIDS RESEARCH
- Cryo-EM structures of tau filaments from Alzheimer’s disease
- (2017) Anthony W. P. Fitzpatrick et al. NATURE
- Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy
- (2017) Emily E. Blythe et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- SAMTOR is anS-adenosylmethionine sensor for the mTORC1 pathway
- (2017) Xin Gu et al. SCIENCE
- Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
- (2017) Sarah L. DeVos et al. Science Translational Medicine
- UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome
- (2016) Roland Hjerpe et al. CELL
- Engineering therapeutic protein disaggregases
- (2016) James Shorter MOLECULAR BIOLOGY OF THE CELL
- Discovery of a First-in-Class, Potent, Selective, and Orally Bioavailable Inhibitor of the p97 AAA ATPase (CB-5083)
- (2015) Han-Jie Zhou et al. JOURNAL OF MEDICINAL CHEMISTRY
- Electron cryotomography of vitrified cells with a Volta phase plate
- (2015) Yoshiyuki Fukuda et al. JOURNAL OF STRUCTURAL BIOLOGY
- Neuroinflammation in Alzheimer's disease
- (2015) Michael T Heneka et al. LANCET NEUROLOGY
- Human Hsp70 Disaggregase Reverses Parkinson’s-Linked α-Synuclein Amyloid Fibrils
- (2015) Xuechao Gao et al. MOLECULAR CELL
- Metabolic and Chaperone Gene Loss Marks the Origin of Animals: Evidence for Hsp104 and Hsp78 Chaperones Sharing Mitochondrial Enzymes as Clients
- (2015) Albert J. Erives et al. PLoS One
- Interplay of Acetyltransferase EP300 and the Proteasome System in Regulating Heat Shock Transcription Factor 1
- (2014) Swasti Raychaudhuri et al. CELL
- Potentiated Hsp104 Variants Antagonize Diverse Proteotoxic Misfolding Events
- (2014) Meredith E. Jackrel et al. CELL
- Robust membrane detection based on tensor voting for electron tomography
- (2014) Antonio Martinez-Sanchez et al. JOURNAL OF STRUCTURAL BIOLOGY
- Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
- (2014) David W. Sanders et al. NEURON
- Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function
- (2013) J. Ross Buchan et al. CELL
- Reversal of Neurofibrillary Tangles and Tau-Associated Phenotype in the rTgTauEC Model of Early Alzheimer's Disease
- (2013) M. Polydoro et al. JOURNAL OF NEUROSCIENCE
- Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
- (2013) Paola Magnaghi et al. Nature Chemical Biology
- Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM
- (2013) Xueming Li et al. NATURE METHODS
- Protein rescue from aggregates by powerful molecular chaperone machines
- (2013) Shannon M. Doyle et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Pathogenic VCP Mutations Induce Mitochondrial Uncoupling and Reduced ATP Levels
- (2013) Fernando Bartolome et al. NEURON
- VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations
- (2013) Nam Chul Kim et al. NEURON
- Functional Analysis of Hsp70 Inhibitors
- (2013) Rainer Schlecht et al. PLoS One
- Introducing Amylo-Glo, a novel fluorescent amyloid specific histochemical tracer especially suited for multiple labeling and large scale quantification studies
- (2012) Larry Schmued et al. JOURNAL OF NEUROSCIENCE METHODS
- Focused ion beam micromachining of eukaryotic cells for cryoelectron tomography
- (2012) A. Rigort et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years
- (2011) Heiko Braak et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Automated segmentation of electron tomograms for a quantitative description of actin filament networks
- (2011) Alexander Rigort et al. JOURNAL OF STRUCTURAL BIOLOGY
- Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations
- (2011) Danilo Ritz et al. NATURE CELL BIOLOGY
- Firefly luciferase mutants as sensors of proteome stress
- (2011) Rajat Gupta et al. NATURE METHODS
- The Mammalian Disaggregase Machinery: Hsp110 Synergizes with Hsp70 and Hsp40 to Catalyze Protein Disaggregation and Reactivation in a Cell-Free System
- (2011) James Shorter PLoS One
- Comparison of ultrafiltration units for proteomic and N-glycoproteomic analysis by the filter-aided sample preparation method
- (2010) Jacek R. Wiśniewski et al. ANALYTICAL BIOCHEMISTRY
- VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
- (2010) Emilie Tresse et al. Autophagy
- Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
- (2010) Janel O. Johnson et al. NEURON
- A Flow Cytometry-Based FRET Assay to Identify and Analyse Protein-Protein Interactions in Living Cells
- (2010) Carina Banning et al. PLoS One
- Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change
- (2008) Bess Frost et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Analyzing real-time PCR data by the comparative CT method
- (2008) Thomas D Schmittgen et al. Nature Protocols
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search