In situ architecture of neuronal α-Synuclein inclusions

Template-free detection and classification of membrane-bound complexes in cryo-electron tomograms

(2020) Antonio Martinez-Sanchez et al.   NATURE METHODS

The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration

(2020) Anne-Laure Mahul-Mellier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

(2020) Ricardo Guerrero-Ferreira et al.   CURRENT OPINION IN NEUROBIOLOGY

Structures of α-synuclein filaments from multiple system atrophy

(2020) Manuel Schweighauser et al.   NATURE

Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports

(2020) Hilal A. Lashuel   NEUROBIOLOGY OF DISEASE

Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases

(2019) Wenjuan Zhang et al.   eLife

A traffic jam leads to Lewy bodies

(2019) Tim Bartels   NATURE NEUROSCIENCE

Lewy pathology in Parkinson’s disease consists of crowded organelles and lipid membranes

(2019) Sarah H. Shahmoradian et al.   NATURE NEUROSCIENCE

Autophagy in Synucleinopathy: The Overwhelmed and Defective Machinery

(2019) Marie-Laure Arotcarena et al.   Cells

α-Synuclein pathology in Parkinson’s disease and related α-synucleinopathies

(2019) Michael X. Henderson et al.   NEUROSCIENCE LETTERS

Parkinson’s disease is a type of amyloidosis featuring accumulation of amyloid fibrils of α-synuclein

(2019) Katsuya Araki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

(2018) W. Peelaerts et al.   CELL AND TISSUE RESEARCH

Order and disorder in the physiological membrane binding of α-synuclein

(2018) Giuliana Fusco et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

(2018) Chao Peng et al.   NATURE

Understanding the Twisted Structure of Amyloid Fibrils via Molecular Simulations

(2018) Lu Lu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Selective imaging of internalized proteopathic α-synuclein seeds in primary neurons reveals mechanistic insight into transmission of synucleinopathies

(2017) Richard J. Karpowicz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Implementation of a cryo-electron tomography tilt-scheme optimized for high resolution subtomogram averaging

(2017) Wim J.H. Hagen et al.   JOURNAL OF STRUCTURAL BIOLOGY

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

The Role of Lipids Interacting with α-Synuclein in the Pathogenesis of Parkinson’s Disease

(2017) Céline Galvagnion   Journal of Parkinsons Disease

Chemical properties of lipids strongly affect the kinetics of the membrane-induced aggregation of α-synuclein

(2016) Céline Galvagnion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

(2016) Kelvin C. Luk et al.   Cell Reports

Structural and functional properties of prefibrillar α-synuclein oligomers

(2016) Laura Pieri et al.   Scientific Reports

Nanomechanical properties of distinct fibrillar polymorphs of the protein α-synuclein

(2016) Ali Makky et al.   Scientific Reports

C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration

(2014) Stephanie May et al.   ACTA NEUROPATHOLOGICA

Robust membrane detection based on tensor voting for electron tomography

(2014) Antonio Martinez-Sanchez et al.   JOURNAL OF STRUCTURAL BIOLOGY

Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

(2014) Laura A Volpicelli-Daley et al.   Nature Protocols

Self-propagation of pathogenic protein aggregates in neurodegenerative diseases

(2013) Mathias Jucker et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

(2012) L. Milanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Focused ion beam micromachining of eukaryotic cells for cryoelectron tomography

(2012) A. Rigort et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automated segmentation of electron tomograms for a quantitative description of actin filament networks

(2011) Alexander Rigort et al.   JOURNAL OF STRUCTURAL BIOLOGY

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability

(2010) Susanne Wegmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

E46K Parkinson’s-Linked Mutation Enhances C-Terminal-to-N-Terminal Contacts in α-Synuclein

(2009) Carla C. Rospigliosi et al.   JOURNAL OF MOLECULAR BIOLOGY

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein

(2008) Katerina E. Paleologou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY