Silica Nanoparticles Trigger Chaperone HSPB8‐Assisted Selective Autophagy via TFEB Activation in Hepatocytes

PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway

(2022) Mihyang Do et al.   Aging-US

Gold Nanoparticles Promote the Bone Regeneration of Periodontal Ligament Stem Cell Sheets Through Activation of Autophagy

(2021) Yangheng Zhang et al.   International Journal of Nanomedicine

Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells

(2021) Xia Qin et al.   Autophagy

The lysosome as an imperative regulator of autophagy and cell death

(2021) Kewal Kumar Mahapatra et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death

(2020) Changfeng Li et al.   Autophagy

Mechanisms governing autophagosome biogenesis

(2020) Hitoshi Nakatogawa   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The interrupted effect of autophagic flux and lysosomal function induced by graphene oxide in p62-dependent apoptosis of F98 cells

(2020) Chao Zhang et al.   JOURNAL OF NANOBIOTECHNOLOGY

The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB

(2020) Zeyuan Zhang et al.   Autophagy

A Crucial Role for the Protein Quality Control System in Motor Neuron Diseases

(2020) Riccardo Cristofani et al.   Frontiers in Aging Neuroscience

Adverse effects of amorphous silica nanoparticles: Focus on human cardiovascular health

(2020) Caixia Guo et al.   JOURNAL OF HAZARDOUS MATERIALS

Iron oxide nanoparticles promote macrophage autophagy and inflammatory response through activation of toll-like Receptor-4 signaling

(2019) Rongrong Jin et al.   BIOMATERIALS

Subchronic toxicity of silica nanoparticles as a function of size and porosity

(2019) Raziye Mohammadpour et al.   JOURNAL OF CONTROLLED RELEASE

Polystyrene Nanoparticles Reduced ROS and Inhibited Ferroptosis by Triggering Lysosome Stress and TFEB Nucleus Translocation in a Size-Dependent Manner

(2019) Lin Li et al.   NANO LETTERS

Silica nanoparticles exacerbates reproductive toxicity development in high-fat diet-treated Wistar rats

(2019) Lianshuang Zhang et al.   JOURNAL OF HAZARDOUS MATERIALS

Silica nanoparticles induce autophagosome accumulation via activation of the EIF2AK3 and ATF6 UPR pathways in hepatocytes

(2018) Ji Wang et al.   Autophagy

Impaired TFEB-mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-induced Liver Injury and Steatosis in Mice

(2018) Xiaojuan Chao et al.   GASTROENTEROLOGY

Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy

(2018) Jun Lin et al.   Small

Necrotic, apoptotic and autophagic cell fates triggered by nanoparticles

(2018) Reza Mohammadinejad et al.   Autophagy

Selective autophagy as a potential therapeutic target for neurodegenerative disorders

(2018) Aurora Scrivo et al.   LANCET NEUROLOGY

mTOR-dependent phosphorylation controls TFEB nuclear export

(2018) Gennaro Napolitano et al.   Nature Communications

Trehalose induces autophagy via lysosomal-mediated TFEB activation in models of motoneuron degeneration

(2018) Paola Rusmini et al.   Autophagy

HSPB8 over‐expression prevents disruption of blood–brain barrier by promoting autophagic flux after cerebral ischemia/reperfusion injury

(2018) Fazhao Li et al.   JOURNAL OF NEUROCHEMISTRY

Carbon monoxide-induced TFEB nuclear translocation enhances mitophagy/mitochondrial biogenesis in hepatocytes and ameliorates inflammatory liver injury

(2018) Hyo Jeong Kim et al.   Cell Death & Disease

Nanoengineered silica: Properties, applications and toxicity

(2017) Andrea M. Mebert et al.   FOOD AND CHEMICAL TOXICOLOGY

Silica nanoparticles induce liver fibrosis via TGF-β1/Smad3 pathway in ICR mice

(2017) Yang Yu et al.   International Journal of Nanomedicine

Silica nanoparticles induce autophagy dysfunction via lysosomal impairment and inhibition of autophagosome degradation in hepatocytes

(2017) Ji Wang et al.   International Journal of Nanomedicine

Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells

(2017) Lingying Zhu et al.   Nanoscale

Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells via P53 signaling

(2017) Caixia Guo et al.   Nanotoxicology

The Role of the Heat Shock Protein B8 (HSPB8) in Motoneuron Diseases

(2017) Paola Rusmini et al.   Frontiers in Molecular Neuroscience

Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway

(2016) Kuang-Kai Liu et al.   Autophagy

TFEB and TFE3 are novel components of the integrated stress response

(2016) J. A. Martina et al.   EMBO JOURNAL

Amorphous silica nanoparticles trigger vascular endothelial cell injury through apoptosis and autophagy via reactive oxygen species-mediated MAPK/Bcl-2 and PI3K/Akt/mTOR signaling

(2016) Caixia Guo et al.   International Journal of Nanomedicine

TFEB at a glance

(2016) Gennaro Napolitano et al.   JOURNAL OF CELL SCIENCE

Nanomaterial-modulated autophagy: underlying mechanisms and functional consequences

(2016) Wei Zheng et al.   Nanomedicine

Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles

(2016) Serge Zhuravskii et al.   TOXICOLOGY MECHANISMS AND METHODS

Mast cell accumulation precedes tissue fibrosis induced by intravenously administered amorphous silica nanoparticles

(2016) Serge Zhuravskii et al.   TOXICOLOGY MECHANISMS AND METHODS

Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases

(2016) Valeria Crippa et al.   Scientific Reports

Autophagy mediated CoCrMo particle-induced peri-implant osteolysis by promoting osteoblast apoptosis

(2015) Zhenheng Wang et al.   Autophagy

Induction and adaptation of chaperone-assisted selective autophagy CASA in response to resistance exercise in human skeletal muscle

(2015) Anna Ulbricht et al.   Autophagy

Silica Nanoparticles Induce Oxidative Stress and Autophagy but Not Apoptosis in the MRC-5 Cell Line

(2015) Sorina Petrache Voicu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cationic polystyrene nanospheres induce autophagic cell death through the induction of endoplasmic reticulum stress

(2015) Hui-Wen Chiu et al.   Nanoscale

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

(2015) Diego L. Medina et al.   NATURE CELL BIOLOGY

Interplay of Oxidative Stress and Autophagy in PAMAM Dendrimers-Induced Neuronal Cell Death

(2015) Yubin Li et al.   Theranostics

The autophagic response to polystyrene nanoparticles is mediated by transcription factor EB and depends on surface charge

(2015) Wensi Song et al.   JOURNAL OF NANOBIOTECHNOLOGY

Ceria Nanoparticles Stabilized by Organic Surface Coatings Activate the Lysosome-Autophagy System and Enhance Autophagic Clearance

(2014) Wensi Song et al.   ACS Nano

HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy

(2014) Serena Carra et al.   Autophagy

In vivo toxicity of orally administrated silicon dioxide nanoparticles in healthy adult mice

(2014) Ramin Hassankhani et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Silica nanoparticles induce autophagy and autophagic cell death in HepG2 cells triggered by reactive oxygen species

(2014) Yongbo Yu et al.   JOURNAL OF HAZARDOUS MATERIALS

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

TFEB regulates autophagy: An integrated coordination of cellular degradation and recycling processes

(2011) Carmine Settembre et al.   Autophagy

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases

(2010) Valeria Crippa et al.   Autophagy

Chaperone-Assisted Selective Autophagy Is Essential for Muscle Maintenance

(2010) Verena Arndt et al.   CURRENT BIOLOGY

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS)

(2010) Valeria Crippa et al.   HUMAN MOLECULAR GENETICS