The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB

Autophagy in liver diseases: Time for translation?

(2019) Manon Allaire et al.   JOURNAL OF HEPATOLOGY

Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans

(2019) Soudabeh Imanikia et al.   CURRENT BIOLOGY

XBP-1 Remodels Lipid Metabolism to Extend Longevity

(2019) Soudabeh Imanikia et al.   Cell Reports

IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs

(2018) Jie-Mei Wang et al.   Science Signaling

IRE1α prevents hepatic steatosis by processing and promoting the degradation of select microRNAs

(2018) Jie-Mei Wang et al.   Science Signaling

Dynamic MTORC1-TFEB feedback signaling regulates hepatic autophagy, steatosis and liver injury in long-term nutrient oversupply

(2018) Hao Zhang et al.   Autophagy

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Salmon provides fast and bias-aware quantification of transcript expression

(2017) Rob Patro et al.   NATURE METHODS

Autophagy in the liver: functions in health and disease

(2017) Takashi Ueno et al.   Nature Reviews Gastroenterology & Hepatology

Quinocetone triggered ER stress-induced autophagy via ATF6/DAPK1-modulated mAtg9a trafficking

(2016) Yan Zhou et al.   CELL BIOLOGY AND TOXICOLOGY

The peroxisome as a cell signaling organelle

(2016) Durga Nand Tripathi et al.   CURRENT OPINION IN CELL BIOLOGY

TFEB and TFE3 are novel components of the integrated stress response

(2016) J. A. Martina et al.   EMBO JOURNAL

XBP1s Is an Anti-lipogenic Protein

(2016) Hilde Herrema et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

The XBP1 Arm of the Unfolded Protein Response Induces Fibrogenic Activity in Hepatic Stellate Cells Through Autophagy

(2016) Rosa S. Kim et al.   Scientific Reports

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

(2015) L. Yang et al.   SCIENCE

Trimmomatic: a flexible trimmer for Illumina sequence data

(2014) Anthony M. Bolger et al.   BIOINFORMATICS

Deficient Chaperone-Mediated Autophagy in Liver Leads to Metabolic Dysregulation

(2014) Jaime L. Schneider et al.   Cell Metabolism

Melatonin Inhibits mTOR-Dependent Autophagy during Liver Ischemia/Reperfusion

(2014) Jung-Woo Kang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

(2014) Xiao-Hong Ma et al.   JOURNAL OF CLINICAL INVESTIGATION

Trehalose Prevents Adipocyte Hypertrophy and Mitigates Insulin Resistance in Mice with Established Obesity

(2014) Chikako ARAI et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Transcriptional regulation of autophagy by an FXR–CREB axis

(2014) Sunmi Seok et al.   NATURE

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Nutrient-sensing nuclear receptors coordinate autophagy

(2014) Jae Man Lee et al.   NATURE

Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA

(2014) Constanza J Cortes et al.   NATURE NEUROSCIENCE

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD

(2014) Á González-Rodríguez et al.   Cell Death & Disease

Hepatic IRE1α regulates fasting-induced metabolic adaptive programs through the XBP1s–PPARα axis signalling

(2014) Mengle Shao et al.   Nature Communications

Aberrant islet unfolded protein response in type 2 diabetes

(2014) Feyza Engin et al.   Scientific Reports

XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells

(2013) Ying Zhao et al.   CELL RESEARCH

Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers

(2013) Jumpei Kashima et al.   HEPATOLOGY RESEARCH

Paneth cells as a site of origin for intestinal inflammation

(2013) Timon E. Adolph et al.   NATURE

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

(2013) Carmine Settembre et al.   NATURE CELL BIOLOGY

Liver autophagy: much more than just taking out the trash

(2013) Jaime L. Schneider et al.   Nature Reviews Gastroenterology & Hepatology

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

(2013) Wafa B’chir et al.   NUCLEIC ACIDS RESEARCH

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

(2012) Rene L. Vidal et al.   HUMAN MOLECULAR GENETICS

XBP1mRNA Splicing Triggers an Autophagic Response in Endothelial Cells throughBECLIN-1Transcriptional Activation

(2012) Andriana Margariti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

(2012) Yingfeng Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

An IFN- -stimulated ATF6-C/EBP- -signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy

(2012) P. Gade et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatic steatosis inhibits autophagic proteolysis via impairment of autophagosomal acidification and cathepsin expression

(2011) Yoshihiro Inami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FIMO: scanning for occurrences of a given motif

(2011) Charles E. Grant et al.   BIOINFORMATICS

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

The unfolded protein response transducer IRE1α prevents ER stress-induced hepatic steatosis

(2011) Kezhong Zhang et al.   EMBO JOURNAL

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

(2011) Michela Palmieri et al.   HUMAN MOLECULAR GENETICS

Regulation of glucose homeostasis through a XBP-1–FoxO1 interaction

(2011) Yingjiang Zhou et al.   NATURE MEDICINE

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

Altered lipid content inhibits autophagic vesicular fusion

(2010) Hiroshi Koga et al.   FASEB JOURNAL

The origin of the autophagosomal membrane

(2010) Sharon A. Tooze et al.   NATURE CELL BIOLOGY

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy

(2009) C. Hetz et al.   GENES & DEVELOPMENT

Hepatic Autophagy Is Suppressed in the Presence of Insulin Resistance and Hyperinsulinemia

(2009) Hui-Yu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

(2009) Yiguo Wang et al.   NATURE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

(2009) Mitsuko Hayashi-Nishino et al.   NATURE CELL BIOLOGY

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis

(2008) C. Hetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1

(2008) A.-H. Lee et al.   SCIENCE

Activation and Dysregulation of the Unfolded Protein Response in Nonalcoholic Fatty Liver Disease

(2007) Puneet Puri et al.   GASTROENTEROLOGY