Scaling up complexity in synthetic developmental biology

Synthetic multistability in mammalian cells

(2022) Ronghui Zhu et al.   SCIENCE

Optogenetic activators of apoptosis, necroptosis, and pyroptosis

(2022) Kateryna Shkarina et al.   JOURNAL OF CELL BIOLOGY

Synthetic developmental biology: New tools to deconstruct and rebuild developmental systems

(2022) Harold M. McNamara et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PERSIST platform provides programmable RNA regulation using CRISPR endoRNases

(2022) Breanna DiAndreth et al.   Nature Communications

Synthetic developmental biology: Engineering approaches to guide multicellular organization

(2022) Ibrahim Zarkesh et al.   Stem Cell Reports

¬Post-Gastrulation Synthetic Embryos Generated Ex Utero from Mouse Naïve ESCs

(2022) Shadi Tarazi et al.   CELL

Embryo model completes gastrulation to neurulation and organogenesis

(2022) Gianluca Amadei et al.   NATURE

Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues

(2022) Guillermo Martínez-Ara et al.   Nature Communications

3D Patterning within Hydrogels for the Recreation of Functional Biological Environments

(2021) Gastón A. Primo et al.   ADVANCED FUNCTIONAL MATERIALS

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

(2021) Alejandro Aguilera-Castrejon et al.   NATURE

Optogenetic relaxation of actomyosin contractility uncovers mechanistic roles of cortical tension during cytokinesis

(2021) Kei Yamamoto et al.   Nature Communications

Optogenetic Rescue of a Patterning Mutant

(2020) Heath E. Johnson et al.   CURRENT BIOLOGY

Exploring the Influence of Cell Metabolism on Cell Fate through Protein Post-translational Modifications

(2020) Oscar A. Tarazona et al.   DEVELOPMENTAL CELL

SCHEEPDOG: Programming Electric Cues to Dynamically Herd Large-Scale Cell Migration

(2020) Tom J. Zajdel et al.   Cell Systems

Using optogenetics to tackle systems-level questions of multicellular morphogenesis

(2020) Jonas Hartmann et al.   CURRENT OPINION IN CELL BIOLOGY

Targeted Protein Degradation Tools: Overview and Future Perspectives

(2020) Yuri Prozzillo et al.   Biology-Basel

Synthetic development: building mammalian multicellular structures with artificial genetic programs

(2019) Marco Santorelli et al.   CURRENT OPINION IN BIOTECHNOLOGY

Synthetic developmental biology: build and control multicellular systems

(2019) Mo R Ebrahimkhani et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Principles and applications of optogenetics in developmental biology

(2019) Daniel Krueger et al.   DEVELOPMENT

Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme

(2018) Alex J. Hughes et al.   DEVELOPMENTAL CELL

Bioelectrical control of positional information in development and regeneration: A review of conceptual and computational advances

(2018) Alexis Pietak et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Programming self-organizing multicellular structures with synthetic cell-cell signaling

(2018) Satoshi Toda et al.   SCIENCE

Programming Morphogenesis through Systems and Synthetic Biology

(2018) Jeremy J. Velazquez et al.   TRENDS IN BIOTECHNOLOGY

Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis

(2018) Emiliano Izquierdo et al.   Nature Communications

Cellular Mechanotransduction: From Tension to Function

(2018) Fabiana Martino et al.   Frontiers in Physiology

Revisiting the role of metabolism during development

(2018) Hidenobu Miyazawa et al.   DEVELOPMENT

Synthetic mammalian pattern formation driven by differential diffusivity of Nodal and Lefty

(2018) Ryoji Sekine et al.   Nature Communications

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Tet-On Systems For Doxycycline-inducible Gene Expression

(2016) Atze T. Das et al.   CURRENT GENE THERAPY

2- and 3-dimensional synthetic large-scale de novo patterning by mammalian cells through phase separation

(2016) Elise Cachat et al.   Scientific Reports

Synthetic lateral inhibition governs cell-type bifurcation with robust ratios

(2015) Mitsuhiro Matsuda et al.   Nature Communications

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Characterizing the mechanics of cultured cell monolayers

(2012) A. R. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

(2010) Xiaobo Wang et al.   NATURE CELL BIOLOGY

An engineered mammalian band-pass network

(2010) D. Greber et al.   NUCLEIC ACIDS RESEARCH

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE

Synthetic morphology: prospects for engineered, self-constructing anatomies

(2008) Jamie A. Davies   JOURNAL OF ANATOMY