Principles and applications of optogenetics in developmental biology

Noninvasive optical activation of Flp recombinase for genetic manipulation in deep mouse brain regions

(2019) Hyunjin Jung et al.   Nature Communications

Light-activated Frizzled7 reveals a permissive role of non-canonical Wnt signaling in mesendoderm cell migration

(2019) Daniel Čapek et al.   eLife

Physical Plasma Membrane Perturbation Using Subcellular Optogenetics Drives Integrin-Activated Cell Migration

(2019) Xenia Meshik et al.   ACS Synthetic Biology

Continued Activity of the Pioneer Factor Zelda Is Required to Drive Zygotic Genome Activation

(2019) Stephen L. McDaniel et al.   MOLECULAR CELL

Signaling Dynamics Control Cell Fate in the Early Drosophila Embryo

(2019) Heath E. Johnson et al.   DEVELOPMENTAL CELL

Self-Organized Nuclear Positioning Synchronizes the Cell Cycle in Drosophila Embryos

(2019) Victoria E. Deneke et al.   CELL

Cross-linker–mediated regulation of actin network organization controls tissue morphogenesis

(2019) Daniel Krueger et al.   JOURNAL OF CELL BIOLOGY

A universal biomolecular integral feedback controller for robust perfect adaptation

(2019) Stephanie K. Aoki et al.   NATURE

Optogenetic inhibition of Delta reveals digital Notch signalling output during tissue differentiation

(2019) Ranjith Viswanathan et al.   EMBO REPORTS

An optogenetic approach to control protein localization during embryogenesis of the sea urchin

(2018) Alicia Uchida et al.   DEVELOPMENTAL BIOLOGY

Chemical waves in cell and developmental biology

(2018) Victoria E. Deneke et al.   JOURNAL OF CELL BIOLOGY

An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation

(2018) Marc Rullan et al.   MOLECULAR CELL

Light-activated protein interaction with high spatial subcellular confinement

(2018) Lorena Benedetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guided morphogenesis through optogenetic activation of Rho signalling during early Drosophila embryogenesis

(2018) Emiliano Izquierdo et al.   Nature Communications

Optogenetic dissection of mitotic spindle positioning in vivo

(2018) Lars-Eric Fielmich et al.   eLife

Downregulation of basal myosin‐II is required for cell shape changes and tissue invagination

(2018) Daniel Krueger et al.   EMBO JOURNAL

From single cells to tissue self-organization

(2018) Aline Xavier da Silveira dos Santos et al.   FEBS Journal

Optogenetic perturbation and bioluminescence imaging to analyze cell-to-cell transfer of oscillatory information

(2017) Akihiro Isomura et al.   GENES & DEVELOPMENT

CRISPR–Cas9-based photoactivatable transcription systems to induce neuronal differentiation

(2017) Yuta Nihongaki et al.   NATURE METHODS

Coupling optogenetics and light-sheet microscopy, a method to study Wnt signaling during embryogenesis

(2017) Prameet Kaur et al.   Scientific Reports

Decoding temporal interpretation of the morphogen Bicoid in the early Drosophila embryo

(2017) Anqi Huang et al.   eLife

Light-induced Notch activity controls neurogenic and gliogenic potential of neural progenitors

(2016) Kyung-Tai Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Light-controlled intracellular transport in Caenorhabditis elegans

(2016) Martin Harterink et al.   CURRENT BIOLOGY

Reversible optogenetic control of kinase activity during differentiation and embryonic development

(2016) Vishnu V. Krishnamurthy et al.   DEVELOPMENT

TAEL: a zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control

(2016) Anna Reade et al.   DEVELOPMENT

Reversible Optogenetic Control of Subcellular Protein Localization in a Live Vertebrate Embryo

(2016) Clare E. Buckley et al.   DEVELOPMENTAL CELL

Functional and topological diversity of LOV domain photoreceptors

(2016) Spencer T. Glantz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optogenetic control of nuclear protein export

(2016) Dominik Niopek et al.   Nature Communications

Optogenetic Control of Nodal Signaling Reveals a Temporal Pattern of Nodal Signaling Regulating Cell Fate Specification during Gastrulation

(2016) Keisuke Sako et al.   Cell Reports

An Optogenetic Method to Modulate Cell Contractility during Tissue Morphogenesis

(2015) Giorgia Guglielmi et al.   DEVELOPMENTAL CELL

Cytoskeletal dynamics: A view from the membrane

(2015) Magdalena Bezanilla et al.   JOURNAL OF CELL BIOLOGY

Engineered pairs of distinct photoswitches for optogenetic control of cellular proteins

(2015) Fuun Kawano et al.   Nature Communications

Control of Protein Activity and Cell Fate Specification via Light-Mediated Nuclear Translocation

(2015) Hayretin Yumerefendi et al.   PLoS One

Passive Mechanical Forces Control Cell-Shape Change during Drosophila Ventral Furrow Formation

(2014) Oleg Polyakov et al.   BIOPHYSICAL JOURNAL

Cell migration: from tissue culture to embryos

(2014) G. Reig et al.   DEVELOPMENT

Spatio-temporally precise activation of engineered receptor tyrosine kinases by light

(2014) M. Grusch et al.   EMBO JOURNAL

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

(2014) William E. Dowdle et al.   NATURE CELL BIOLOGY

An optogenetic gene expression system with rapid activation and deactivation kinetics

(2014) Laura B Motta-Mena et al.   Nature Chemical Biology

Reversible protein inactivation by optogenetic trapping in cells

(2014) Sangkyu Lee et al.   NATURE METHODS

Engineering an improved light-induced dimer (iLID) for controlling the localization and activity of signaling proteins

(2014) Gurkan Guntas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering light-inducible nuclear localization signals for precise spatiotemporal control of protein dynamics in living cells

(2014) Dominik Niopek et al.   Nature Communications

An optimized optogenetic clustering tool for probing protein interaction and function

(2014) Amir Taslimi et al.   Nature Communications

Optical control of mammalian endogenous transcription and epigenetic states

(2013) Silvana Konermann et al.   NATURE

The Amino-Terminal Helix Modulates Light-Activated Conformational Changes in AsLOV2

(2012) Josiah P. Zayner et al.   JOURNAL OF MOLECULAR BIOLOGY

TULIPs: tunable, light-controlled interacting protein tags for cell biology

(2012) Devin Strickland et al.   NATURE METHODS

Spatiotemporal control of gene expression by a light-switchable transgene system

(2012) Xue Wang et al.   NATURE METHODS

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

Ligand-Specific c-Fos Expression Emerges from the Spatiotemporal Control of ErbB Network Dynamics

(2010) Takashi Nakakuki et al.   CELL

Catastrophic cascade of failures in interdependent networks

(2010) Sergey V. Buldyrev et al.   NATURE

Light-mediated activation reveals a key role for Rac in collective guidance of cell movement in vivo

(2010) Xiaobo Wang et al.   NATURE CELL BIOLOGY

Rapid blue-light–mediated induction of protein interactions in living cells

(2010) Matthew J Kennedy et al.   NATURE METHODS

Spatiotemporal control of cell signalling using a light-switchable protein interaction

(2009) Anselm Levskaya et al.   NATURE

A genetically encoded photoactivatable Rac controls the motility of living cells

(2009) Yi I. Wu et al.   NATURE